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The Use of Baclofen to Control Vertical Nystagmus in a Patient with Advanced Glioma: A Case Report

  • Luma Alfraihat (Department of Palliative Care, Comprehensive Cancer Center, King Fahad Medical City) ;
  • Sami Ayed Alshammary (Department of Palliative Care, Comprehensive Cancer Center, King Fahad Medical City) ;
  • Hassan Yousef Alghar (Department of Palliative Care, Comprehensive Cancer Center, King Fahad Medical City)
  • Received : 2024.10.08
  • Accepted : 2024.11.18
  • Published : 2024.12.01

Abstract

Nystagmus, characterized by involuntary eye movements, can arise from several causes, with benign paroxysmal positional vertigo being the most prevalent. Additionally, central lesions such as tumors may also induce nystagmus. This case report describes the amelioration of vertical nystagmus in a patient with advanced glioma after treatment with the GABAergic drug baclofen.

Keywords

References

  1. Bertholon P, Tringali S, Faye MB, Antoine JC, Martin C. Prospective study of positional nystagmus in 100 consecutive patients. Ann Otol Rhinol Laryngol 2006;115:587-94. https://doi.org/10.1177/000348940611500804
  2. Choi JY, Kim JH, Kim HJ, Glasauer S, Kim JS. Central paroxysmal positional nystagmus: Characteristics and possible mechanisms. Neurology 2015;84:2238-46. https://doi.org/10.1212/WNL.0000000000001640
  3. Arai M, Terakawa I. Central paroxysmal positional vertigo. Neurology 2005;64:1284.
  4. Cho BH, Kim SH, Kim SS, Choi YJ, Lee SH. Central positional nystagmus associated with cerebellar tumors: Clinical and topographical analysis. J Neurol Sci 2017:373:147-51. https://doi.org/10.1016/j.jns.2016.12.050
  5. Sarvananthan N, Surendran M, Roberts EO, Jain S, Thomas S, Shah N, et al. The prevalence of nystagmus: the Leicestershire nystagmus survey. Invest Ophthalmol Vis Sci 2009;50:5201-6. https://doi.org/10.1167/iovs.09-3486
  6. Averbuch-Heller L, Tusa RJ, Fuhry L, Rottach KG, Ganser GL, Heide W, et al. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Ann Neurol 1997;41:818-25. https://doi.org/10.1002/ana.410410620
  7. Kalla R, Glasauer S, Büttner U, Brandt T, Strupp M. 4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmus. Brain 2007;130(Pt 9):2441-51. https://doi.org/10.1093/brain/awm172
  8. Baloh RW, Honrubia V. Clinical neurophysiology of the vestibular system. 3rd ed. New York:Oxford University Press;2001.
  9. Yun SY, Lee JH, Kim HJ, Choi JY, Kim JS. Effects of baclofen on central paroxysmal positional downbeat nystagmus. Cerebellum 2024:23;1892–8.
  10. Dieterich M, Straube A, Brandt T, Paulus W, Buttner U. The effects of baclofen and cholinergic drugs on upbeat and downbeat nystagmus. J Neurol Neurosurg Psychiatry 1991;54:627-32. https://doi.org/10.1136/jnnp.54.7.627