대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제50권4호
  • /
  • Pages.387-398
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  • 2024
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  • 1226-2587(pISSN)
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  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
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피부 미백 개선 효과가 있는 신규 미백 펩타이드 탐색 및 도출

Exploration and Derivation of Novel Whitening Peptides with Skin Whitening Improvement Effects

  • 강상문 (에이앤펩(주) 기술연구소) ;
  • 전용승 (에이앤펩(주) 기술연구소) ;
  • 이기영 (에이앤펩(주) 기술연구소) ;
  • 박청 (대전대학교 생명과학전공)
  • 투고 : 2024.12.06
  • 심사 : 2024.12.27
  • 발행 : 2024.12.30
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초록

다양한 유래에서 도출된 5 종의 펩타이드에 대한 펩타이드 합성법 및 기시법을 정립하고 화장품 소재로서의 적합성을 검증하기 위해 피부세포 독성확인 및 티로시나아제(tyrosinase) 억제능, 멜라닌(melanin) 생성 저해능 등의 펩타이드의 피부 미백효과를 검증하기 위한 다양한 실험을 진행하였으며 미백 개선 임상시험을 통해 선별된 1 종의 펩타이드인 KGYSS 아미노산 서열의 펜타펩타이드의 피부 미백 개선 효과를 확인할 수 있었다. 이상의 결과로부터 신규 서열의 펜타펩타이드는 피부 미백 개선 효능을 가진다고 사료되며, 향후 미백 기능성 화장품 원료로서의 이용 가능성을 보였다.

A peptide synthesis method and a specification and test method for five types of peptides derived from various origins were established. Various experiments were conducted to verify the skin whitening effect of peptides such as confirming skin cell toxicity, tyrosinase inhibition, and melanin production inhibition. Through the whitening improvement clinical test, the skin whitening improvement effect of the pentapeptide of the amino acid sequence of KGYSS, which was selected, was confirmed. From the above results, the new sequence of pentapeptides is considered to have the effect of improving skin whitening, and has shown potential to be used as a raw material for whitening functional cosmetics in the future.

키워드

과제정보

This research was supported by the Ministry of Trade, Industry & Energy(MOTIE), Korea Planning & Evaluation Institute of Industrial Technology (KEIT) through the Encouragement Program for Bio industry core technology development project (Project NO: 20009105)

참고문헌

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