대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제50권4호
  • /
  • Pages.319-325
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  • 2024
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  • 1226-2587(pISSN)
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  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
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블루라이트에 대한 팽화처리된 황련뿌리 추출물의 Hs68 세포 보호효과

The Protective Effects of Puffing-processed Coptis japonica Root Extract on the Hs68 Cells Against Blue Light Emitted from Digital Devices

  • 강준철 ((주)더마랩 기술연구소) ;
  • 윤유경 ((주)더마랩 기술연구소) ;
  • 김소희 (충북대학교 약학대학) ;
  • 손동주 (충북대학교 약학대학) ;
  • 홍진태 (충북대학교 약학대학) ;
  • 박현철 ((주)더마랩 기술연구소)
  • Jun-Chul Kang (Dermalab Co., Ltd., R&D Center) ;
  • Yoo-Gyeong Yoon (Dermalab Co., Ltd., R&D Center) ;
  • So Hui Kim (College of Pharmacy, Chungbuk National University) ;
  • Dong Ju Son (College of Pharmacy, Chungbuk National University) ;
  • Jin Tae Hong (College of Pharmacy, Chungbuk National University) ;
  • Hyun-Chul Park (Dermalab Co., Ltd., R&D Center)
  • 투고 : 2024.10.30
  • 심사 : 2024.12.10
  • 발행 : 2024.12.30
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초록

블루라이트(380 ~ 500 nm)는 가시광선 중 가장 높은 에너지를 가지며, 피부 세포에서 활성산소(ROS), 염증, 그리고 세포자연사(apoptosis)를 유도하는 것으로 알려져 있다. 블루라이트에 대한 피부 보호 효과가 있는 천연 물질을 탐색하는 과정에서, 황련(Coptis japonica) 뿌리 추출물이 유의미한 보호 효과를 나타낸다는 것을 확인하였다. 황련은 아시아에서 자라는 다년생 약용 식물로, 항염증, 항산화 및 항균 특성으로 잘 알려져 있다. 본 연구에서는 블루라이트로부터 피부세포를 보호하는 황련의 효과를 연구하기 위해, 퍼핑 처리된 황련 추출물(PCE)을 사용하였다. PCE는 DPPH를 통해 항산화 효과를 확인하였으며, Hs68 세포에 블루라이트 노출 전후에 처리한 결과, PCE가 세포보호, 세포 내 활성산소 감소, DNA 손상 및 세포자연사를 억제하는 것을 확인 하였다. 이러한 결과는 PCE가 블루라이트로부터 피부세포 손상을 방지하는 광보호제로서의 가능성을 지닌다고 사료된다.

Blue light (380 ~ 500 nm) has the highest energy among visible wavelengths and is known to induce free radicals, inflammation, and apoptosis in skin cells. In our search for natural materials with protective effects against blue light, we found that Coptis japonica root extract demonstrates a significant protective effect. C. japonica is a perennial medicinal plant grown in Asia, known for its anti-inflammatory, antioxidant, and antibacterial properties. In this study, we evaluated its efficacy against the harmful effects of blue light (BL) using gun-puffed C. japonica (PCE). The antioxidant effect of PCE was confirmed by DPPH, and treatment of Hs68 cells before and after blue light exposure confirmed that PCE provided cytoprotection, reduced intracellular free radicals, and inhibited DNA damage and apoptosis. These findings indicate that PCE may serve as a promising candidate for a photoprotective agent to prevent skin cell damage from blue light exposure.

키워드

과제정보

본 연구는 중소벤처기업부와 한국산업기술진흥원의 "지역특화산업육성사업(R&D, S3268465)"으로 수행된 연구결과 입니다.

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