DOI QR코드

DOI QR Code

백반증의 침구(鍼灸) 치료 효과: 무작위 대조 시험에 대한 주제 범위 문헌 고찰

Effect of Acupuncture and Moxibustion for Vitiligo: A Scoping Review of Randomized Controlled Trials

  • 한도경 (부산대학교 한의과대학 약물의학부) ;
  • 손지원 (부산대학교 한의과대학 약물의학부) ;
  • 안원근 (부산대학교 한의과대학 약물의학부)
  • Do Kyung Han (Dep. of Pharmacology, College of Korean Medicine, Pusan National University) ;
  • Jeewon Shon (Dep. of Pharmacology, College of Korean Medicine, Pusan National University) ;
  • Won Gun An (Dep. of Pharmacology, College of Korean Medicine, Pusan National University)
  • 투고 : 2023.10.07
  • 심사 : 2023.11.05
  • 발행 : 2023.11.25

초록

Objectives : The aim of this study is to review the effect of acupuncture/moxibustion on vitiligo. Methods : Using 5 databases(Pubmed, EMBASE, Cochrane Library, RISS, OASIS) clinical studies about effect of acupuncture/moxibustion on vitiligo were searched. Only randomized controlled trials(RCTs) were selected to analyze. Results : Total 235 studies were searched. After screening those studies 5 studies were selected from china and Iran. 3 studies used effective rate to measure the effect of acupuncture for vitiligo. 1 study used Vitiligo Area Scoring Index(VASI) and 1 study assessed 4 grade of repigmentation to prove acupuncture's effect on vitiligo. All studies showed repigmentation in acupuncture/moxibustion group. Adverse effects reported in the five studies were temporary erythema, itching, and dryness. Conclusions : These findings suggest that acupuncture and moxibustion can be considered a safe treatment for vitiligo. However, due to the small number of RCTs conducted on acupuncture and moxibustion for vitiligo, more RCTs should be conducted to confirm the effectiveness of acupuncture and moxibustion for vitiligo.

키워드

참고문헌

  1. Whitton ME, Pinart M, Batchelor J, Leonardi-Bee J, Gonzalez U, Jiyad Z, et al. Interventions for vitiligo. Cochrane Database Syst Rev. 2015;2015(2):1-42.  https://doi.org/10.1002/14651858.CD003263.pub5
  2. Bergqvist C, Ezzedine K. Vitiligo: A Review. Dermatology. 2020;236(6):571-92.  https://doi.org/10.1159/000506103
  3. Das SK, Majumder PP, Chakrabotry R, Majumdar TK, Haldar B. Studies on vitiligo I. Epidemiological profile in Calcutta, India. Genet Epidemiol. 1985;2(1):71-8.  https://doi.org/10.1002/gepi.1370020107
  4. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol. 2011;65(3):473-91.  https://doi.org/10.1016/j.jaad.2010.11.061
  5. Sehgal VN, Srivastava G. Vitiligo: compendium of clinico-epidemiological features. Indian J Dermatol Venereol Leprol. 2007;73(3):149-56.  https://doi.org/10.4103/0378-6323.32708
  6. Nicolaidou E, Antoniou C, Miniati A, Lagogianni E, Matekovits A, Stratigos A, et al. Childhood- and later-onset vitiligo have diverse epidemiologic and clinical characteristics. J Am Acad Dermatol. 2012;66(6):954-8.  https://doi.org/10.1016/j.jaad.2011.07.010
  7. Ezzedine K, Diallo A, Leaute-Labreze C, Seneschal J, Boniface K, Cario-Andre M, et al. Pre- vs. post-pubertal onset of vitiligo: multivariate analysis indicates atopic diathesis association in pre-pubertal onset vitiligo. Br J Dermatol. 2012;167(3):490-5.  https://doi.org/10.1111/j.1365-2133.2012.11002.x
  8. Kim YS, Suhr KB, Lee JH, Park JK. Response of PUVA Therapy in Vitiligo Patients. Korean Journal of Dermatology. 1999;37(12):1752-60.  https://doi.org/10.1046/j.1365-4362.1998.00549.x
  9. Mohaghegh F, Asilian A, Faghihi G, Adibi N. A Comparison between the efficacy of narrow band ultra violet B phototherapy with and without needling of the lesion in the treatment of vitiligo. Journal of Research in Medical Sciences. 2012;17:131-3. 
  10. Zheng WG. Treatment of 58 cases of vitiligo by electro-plum-blossom needle therapy combined with catgut implantation of acupoints under TDP radiation. Chinese acupuncture & moxibustion. 2005;25(2):85,86. 
  11. Zhang Y, Chen C, Huang S, Zhou J. Efficacy observation of fire needle combined with narrow band ultraviolet-B(NB-UVB) for vitiligo. Chinese Acupuncture & Moxibustion. 2013;33(2):121-4. 
  12. Yu G, AI Y. Clinical observation on focal vitiligo treated with heat-sensitive moxibustion in comparison with medication. Chinese acupuncture & Moxibustion. 2014;34(4):337-40. 
  13. Chu GY, Weng SM, Huang CC, Chun LW, Hsu CH, Wu HS, et al. Surrounding Needling and Narrowband Ultraviolet B Phototherapy Treatment: Synergistic Effects for Repigmentation in Chronic, Stable Nonsegmental Vitiligo ORIGINAL RESEARCH. Alternative therapies. 2023;29(1):97-103. 
  14. Ziaeifar E, Ziaeifar F, Mozafarpoor S, Goodarzi A. Applications of microneedling for various dermatologic indications with a special focus on pigmentary disorders: A comprehensive review study. Dermatologic Therapy. 2021;34(6):1-13.  https://doi.org/10.1111/dth.15159
  15. Lee JH, Kim SY. Four cases of vitiligo patients treated by Oriental medical treatment who have experienced Excimer Laser treatment. J Korean Med Ophthalmol Otolaryngol Dermatol. 2014;27(3):205-12.  https://doi.org/10.6114/jkood.2014.27.3.205
  16. Bak S, Song Y, Lee S, Yoon DH, Kim S. Publication Trends in ST36 Electroacupucnture Researches in Korean Journals. Korean Journal of Acupuncture. 2022;39(4):126-31.  https://doi.org/10.14406/acu.2022.021
  17. Du MH, Luo HM, Hu S, Lv Y, Lin ZL, Ma L. Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism. World J Gastroenterol. 2013;19(36):5988-99.  https://doi.org/10.3748/wjg.v19.i36.5988
  18. Lai F, Ren Y, Lai C, Chen R, Yin X, Tan C, et al. Acupuncture at Zusanli (ST36) for Experimental Sepsis: A Systematic Review. Evidence-based Complementary and Alternative Medicine. 2020;2020(1):1-16.  https://doi.org/10.1155/2020/3620741
  19. Wang H, Pan Y, Xue B, Wang X, Zhao F, Jia J, et al. The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease. PLoS One. 2011;6(5):1-8.  https://doi.org/10.1371/journal.pone.0019790
  20. Speeckaert R, Dugardin J, Lambert J, Lapeere H, Verhaeghe E, Speeckaert M, et al. Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(7):1089-98.  https://doi.org/10.1111/jdv.14792
  21. Park C. A study on anti-oxidative effect of electroacupuncture at Kokchi in rats. The Journal of Korean Acupuncture & Moxibustion society. 2007;24(3):81-97. 
  22. Van-Geel N, Hamzavi IH, Pandya AG, Wolkerstorfer A, Seneschal J, Garg A, et al. Vitiligo International Task force for an Agreed List of core data (VITAL): study protocol of a vitiligo core outcome set (COS) and contextual factors for clinical trials, registries, and clinical practice. Trials. 2022;23(1):1-9.  https://doi.org/10.1186/s13063-021-05959-2
  23. Luo Y, Qian W, Dai T, Ru Y, Sun X, Kuai L, et al. A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects. Evid Based Complement Alternat Med. 2020;2020(1):1-19. https://doi.org/10.1155/2020/8492097