The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Herbal Medicine Treatment for Cold Urticaria: A Systematic Review and Meta-Analysis

한랭 두드러기에 대한 한약 치료: 체계적 문헌 고찰 및 메타분석

  • Hae-Na Kim (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dong-Eui University) ;
  • Jeong-Hwa Oh (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dong-Eui University) ;
  • Hwa-Jung Yoon (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Dong-Eui University)
  • 김혜나 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 오정화 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 윤화정 (동의대학교 한의과대학 안이비인후피부과학 교실)
  • Received : 2023.10.07
  • Accepted : 2023.10.31
  • Published : 2023.11.25
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Abstract

Objectives : The purpose of this study is to evaluate the effects of herbal medicine treatment in patients with cold urticaria. Methods : We searched randomized controlled trials(RCTs) reporting the effects of herbal medicine for cold urticaria through domestic and international databases from their inception to September 2023. The results were summarized in tables. We assessed the risk of bias in included RCTs through Cochrane risk of bias tool and the data synthesis was conducted through RevMan version 5.4. Results : A total of 12 RCTs were included in this review and all trials compared herbal medicine alone treatment(treatment group) with western medicine alone treatment(control group). The total effective rate(TER) of treatment group was statistically higher than that of control group(RR: 1.49, 95% CI: 1.38 to 1.62, p<0.00001, I2=65%). On the other hand, when comparing except for 1 trial with different evaluation period, the TER of treatment group was statistically higher than that of control group and heterogeneity was very low(RR: 1.36, 95% CI: 1.26 to 1.47, p<0.00001, I2=0%). And when comparing 8 trials using the total symptom score(TSS) change index as an indicator of TER, the TER of treatment group was statistically higher than that of control group and heterogeneity was very low(RR: 1.38, 95% CI: 1.26 to 1.51, p<0.00001, I2=0%). The treatment group showed more statistically significant decrease compared to the control group in TSS(MD: -2.51, 95% CI: -2.63 to -2.40, p<0.00001, I2=99%). The relapse rate of treatment group was statistically lower than that of control group(RR: 0.19, 95% CI: 0.10 to 0.40, p<0.00001, I2=0%). Mild adverse events such as sleepiness, dizziness were reported in control group and gastric discomfort was reported in treatment group. In the risk of bias assessment, many cases were evaluated as 'Unclear risk'. Conclusions : This review found that herbal medicine alone treatment could more effective and safe than western medicine alone treatment for cold urticaria. But further well-designed researches are needed because of heterogeneity between trials and the quality of the included trials.

Keywords

References

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