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Research Trend of Oriental Medical Treatments for Burning Mouth Syndrome

구강작열감증후군의 한의학적 치료에 대한 최근 국내외 임상 연구 동향

  • Ji-Min Choi (Department of Ophthalmology, Otolaryngology & Dermatology, College of Korean Medicine, Wonkwang University) ;
  • Seok-Hun Hong (Department of Ophthalmology, Otolaryngology & Dermatology, College of Korean Medicine, Wonkwang University)
  • 최지민 (원광대학교 한의과대학 안이비인후피부과학교실) ;
  • 홍석훈 (원광대학교 한의과대학 안이비인후피부과학교실)
  • Received : 2023.10.09
  • Accepted : 2023.10.31
  • Published : 2023.11.25

Abstract

Objectives : The purpose of this study is to analyze the oriental medical treatments of burning mouth syndrome, understand the tendency of treatment, and apply it to clinical settings. Methods : We collected case reports, retrospective cohort studies and RCT studies related to oriental medical treatments of burning mouth syndrome using domestic and Chinese databases(CNKI, KISS, RISS, OASIS, KCI). Search terms include 'Burning Mouth Syndrome', 'BMS', 'Burning Tongue', '灼口综合征', and 'oriental medicine', 'oriental medical treatment', 'Korean medicine' and '中医'. A search was conducted by appropriately combining keywords. Results : A total of 27 papers were included in the analysis. Among them, 9 are case studies, 1 is a retrospective cohort study, 1 is a before and after study and 16 are RCT studies. Treatments for burning mouth syndrome included herbal medicine, acupuncture, electro-acupuncture, acupoint injection, auricular acupuncture treatment, external use herbal medicine and gargling. In all studies, symptoms of burning mouth syndrome were alleviated after oriental medical treatments. In 14 RCT studies comparing western medical treatments, the results of the treatment group that included oriental medical treatments were found to be more significant, except for one. Conclusions : As a result of the study, oriental medical treatments are effective in treating burning mouth syndrome. In the future, we hope that clinical research related to oriental medical treatments of burning mouth syndrome will be actively conducted so that evidence-based treatment can be implemented.

Keywords

References

  1. Headache Classification Committee of the International Headache Society(IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808.  https://doi.org/10.1177/0333102413485658
  2. Klasser GD, Epstein JB. Oral burning and burning mouth syndrome. J Am Dent Assoc. 2012;143(12):1317-9.  https://doi.org/10.14219/jada.archive.2012.0093
  3. Korea Society of Otorhinolaryngology-Head and Neck Surgery. Otorhinolaryngology-Head and Neck Surger:Head and Neck. Paju:Gunja Publishing House. 2018:297-9. 
  4. Choi SH, Lee BN, Lim HS, Oh WM, Kim JH. A literature review on burning mouth syndrome. Journal of Dental Rehabilitation and Applied Science. 2019;35(3):123-31.  https://doi.org/10.14368/jdras.2019.35.3.123
  5. Jin JP. Hwangjenaegyeong, book for reading and recitation(clinical application). Seoul:Bubin publishers. 2009:567. 
  6. Sun YK. Chishui xuanzhu quanji(The Secret Ball of the Red Water). Beijing:People's medical publishing house. 1986:75. 
  7. Heo J. Donguibogam(new edition). Seoul: Bubin publishers. 2012:677. 
  8. Shim SR, Kim MK, Lee JH, Lu HY, Cho SY, Park SU, et al. Observational Study of Glossodynia. The Journal of Korean Oriental Internal Medicine. 2012;33(4):476-84. 
  9. Kim DY, Ha NY, Kim JS. Study on the Relationship between Pattern Identifications for Patients with Burning Mouth Syndrome and the Ryodoraku Test. The Journal of Korean Oriental Internal Medicine. 2020;41(4):624-43.  https://doi.org/10.22246/jikm.2020.41.4.624
  10. Son JY, Kim JY, Kang K, Baek SH, Choi J, Jang SW, et al. Effects of Korean Medicine Therapies on Oral Pain in Patients with Burning Mouth Syndrome: a Before and After Study. The Journal of Korean Oriental Internal Medicine. 2013;34(2):122-33. 
  11. Lee JE, Park JW, Kim JS. Correlation between Dysgeusia and Spleen qi Deficiency Patterns in Patients with Burning Mouth Syndrome. The Journal of Korean Oriental Internal Medicine. 2017;38(4):455-67.  https://doi.org/10.22246/jikm.2017.38.4.455
  12. Kim YJ, Yang SB, Kim JH, Lee SH, Cho SY, Park SU, et al. Three Case Reports of Glossodynia Patients Treated with Cheonggansoyo-san. The Journal of Korean Oriental Internal Medicine. 2017;38(4):491-500.  https://doi.org/10.22246/jikm.2017.38.4.491
  13. Kim NE, Kim YS, Jee SY, Hwangbo M. 6 Cases of Burning Mouth Syndrome Treated by Korean Medical Treatment. J Korean Med Ophthalmol Otolaryngol Dermatol. 2019;32(3):244-53. 
  14. Zhao JP, Ma LX, Li FH. Comparative Analysis of Zuogui Pill in Treating Perimenopausal Patients with Burning Mouth Syndrome in Other Patients. Chinese Journal of Aesthetic Medicine. 2012;21(8):261. 
  15. Yu G, Lin K, Zhao XY, Yan X, Tan CX. Clinical Observation on the Treatment of Primary Burning Mouth Syndrome Based on "Taiyin Deficiency Cold" from Treatise on Febrile Diseases. Western Journal of Traditional Chinese Medicine. 2023;36(3):115-8. 
  16. Gao H, Shi WW, Ye YJ. Observation on the Curative Effect of Fire-inducing Method in the Treatment of Burning Mouth Syndrome. Clinical Journal of Chinese Medicine. 2020;12(21):96-8. 
  17. Xie ZW, Pian LP, Han FY. Combination of Chinese and Western Medicine in the Treatment of Burning Mouth Syndrome. Acta Chinese Medicine. 2019;34(9):1981-4. 
  18. Wan Y, Zhao LQ. Clinical Observations on Tongue Acupuncture plus Body Acupuncture for Burning Mouth Syndrome. Shanghai Journal of Acupuncture and Moxibustion. 2019;38(8):908-11. 
  19. Xiong LZ, Su YJ, Zhang XL, Si DM, Yuan SW. Clinical Study on Self-made Jianghuo Formula in Treatment of Yin-deficiency and Fire-excess Type of Burning Mouth Syndrome. Acta Chinese Medicine. 2018;33(7):1345-8. 
  20. Hou WW, Wan KZ, Zhang Y. Clinical Observation of Using Modified Shenling Baizhu Powder in the Treatment of Cauterization Syndrome. Journal of Sichuan of Traditional Chinese Medicine. 2020;38(4):194-6. 
  21. Zhang ZD, Li JL, Huang XJ, Wen JH, Jiang HG, Zhang QY. Evaluation of the Effectiveness of Tongue base Bloodletting in 60 Patients with Burning Mouth Syndrome. Contemporary Medical Symposium. 2018;16(14):178,179. 
  22. Liu CL. Observation on the Curative Effect of Modified Xiaochaihu Decoction on Burning Mouth Syndrome. Modern Traditional Chinese Medicine. 2017;37(4):60-2. 
  23. Zhang XX. Adjunctive Therapeutic Effect of Xuefuzhuyu Decoction on Patients with Burning Mouth Syndrome. Henan Medical Research. 2020;29(24):4548-50. 
  24. Ge SY, Zhou HW, Wan Y, Zhou ZT. Clinical Effect of Auricular Point Therapy on Burning Mouth Syndrome. Journal of Prevention and Treatment for Stomatological Diseases. 2020;28(3):174-7. 
  25. Yang B. Treatment Based on Syndrome Differentiation of 36 Cases of Burning Mouth Syndrome. Traditional Chinese Medicinal Research. 2007;5:46,47. 
  26. Chen XQ, Xie JS, Wu ZY, Xu JQ. Traditional Chinese Medicine Differentiation and Treatment of 34 Cases of Burning Mouth Syndrome. Journal of Traditional Chinese Medicine. 2004;10:765,766. 
  27. Zhou B, Zhou J. Observation on the Treatment of Zhuokou decoction on Yin deficiency type of Burning mouth syndrome. Journal of Clinical Stomatology. 2012;28(4):217,218. 
  28. Yang MJ. Treatment of 33 Cases of Burning Mouth Syndrome by Syndrome Differentiation and Western Medicine. Guangming Journal of Chinese Medicine. 2011;26(4):799. 
  29. Zhou Q, Zhang L. Observation on the Effect and Clinical Nursing of Combination of Chinese and Western Medicine in Treatment of Burning Mouth Syndrome. Journal of Nurses Training. 2009;24(23):2192,2193. 
  30. Peng YZ, Liu BZ, Zhao SK. Observation on the Curative Effect of Modified Zuogui Pill on Burning Mouth Syndrome. Electronic Journal of General Stomatology. 2019;6(24):66,67. 
  31. Hu XY, Bu SS, Gui G, Sun KY, Zhang L. Observation on the Curative Effect of Shuanghua Baihe Tablet on Burning Mouth Syndrome. Journal of China Prescription Drug. 2016;14(12):54,55. 
  32. Li JR, Hou WY, Gong WX, Qin YN. Treatment of Chaishao Liujunzi Decoction for 32 Women with Burning Mouth Syndrome. Chinese Medicine Modern Distance Education of China. 2011;9(19):34,35. 
  33. Guo HQ. The Traditional Chinese Medicine Dialectical Treatment Burns Mouth Syndrome Clinical Observation. Journal of Diseases Monitor & Control. 2009;3(8):484,485. 
  34. Huang XP. Clinical Observation of 80 Cases of Burning Mouth Syndrome Treated with Lianmei Decoction. Stomatology. 2007;11:615,616. 
  35. Lou JN, Zhou HW, Ge SY. Effect of Auricular Point Therapy on the Psychological State and Plasma β-endorphin Level of Patients with Burning Mouth Syndrome. Journal of Prevention and Treatment for Stomatological Diseases. 2023;31(7):501-5. 
  36. Zhao YJ, Li YC. Experience of the Treatment of Burning Mouth Syndrome Based on the Liver-Kidney Theory. Journal of Practical Stomatology. 2020;36(2):378-80. 
  37. Wang SN, Xie SJ, Wang ZH. Treatment of 20 Cases of Burning Mouth Syndrome with Guan's Tongue Acupuncture. Chinese Acupuncture & Moxibustion. 2015;35(7):695,696. 
  38. Sun YN, Wu YT, Wang WC. Auricular Acupuncture for Burning Mouth Syndrome. Medical Journal of Qilu. 2011;26(5):446,447. 
  39. National Korean Medicine University Textbook Editing Board. Traditional Herbology. Seoul:Younglimsa. 2011:10-8. 
  40. College of Korean medicine, Gyeongsan University. Hospital drug formulary. Daegu:Daejin publishers. 1990:123. 
  41. Song IB, Hong ND, Kim NJ, Ko BH. Studies on the Efficacy of Combined Preparation of Crude Drugs (XXVII) -Experimental studies on the efficacy of Chunghyulgangki-Tang-. Korean Journal of Pharmacognosy. 1986;17(2):113-22. 
  42. Kyunghee Korean Medicine Hospital. Kyunghee herbal formulary. Seoul:Nado publisher. 1997:80. 
  43. Oh K. Euijongguemgam. Seoul:Daesung Moon Wha Inc. 1983:49-51. 
  44. Kim DH. Soayakjeungjikgyeol. Seoul:Eui Seong Dang Publishing Co. 2002:110. 
  45. Hwang DY. Daeyoungjeungmaek - Bangyak happyun. 2nd ed. Seoul:Namsandang. 2014:269,270. 
  46. Yun YG. Donguibangjae & prescription interpretation. Seoul:EuiSeongDang Publishing Co. 2007:508-30,604,707,733,754,755,759,760. 
  47. Chen SW. Taepyeonghyeminhwajegukbang: the 5th volume. Taipei:Publisher of Seonpung. 1975:9. 
  48. Zhang JB. Gyeongakjeonseo. Daegu:East synthesize communication education publishing company. 1982:642,678,980,981. 
  49. Wang HM, Zheng L, Cong HJ, Fang LX, Zhu HR, Wu B, et al. Chemical Constituents from Shuanghua Baihe Tablets. Chinese Journal of Modern Applied Pharmacy. 2016;33(5):572-6. 
  50. Kohorst JJ, Bruce AJ, Torgerson RR, Schenck LA, Davis MDP. The prevalence of burning mouth syndrome: a population-based study. Br J Dermatol. 2015;172(6):1654-6.  https://doi.org/10.1111/bjd.13613
  51. Bergdahl M, Bergdahl J. Burning mouth syndrome: prevalence and associated factors. J Oral Pathol Med. 1999;28(8):350-4.  https://doi.org/10.1111/j.1600-0714.1999.tb02052.x
  52. Woda A, Dao T, Gremeau-Richard C. Steroid dysregulation and stomatodynia(Burning mouth syndrome). J Orofac Pain. 2009;23(3):202-10. 
  53. Ducasse D, Courtet P, Olie E. Burning mouth syndrome:current clinical, physiopathologic, and therapeutic data. Reg Anesth Pain Med. 2013;38(5):380-90.  https://doi.org/10.1097/AAP.0b013e3182a1f0db
  54. Bartoshuk LM, Snyder DJ, Grushka M, Berger AM, Duffy VB, Kveton JF. Taste damage:previously unsuspected consequences. Chem Senses. 2005;30(Suppl1):218,219. 
  55. Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome. Am Fam Physician. 2002;65:615-20. 
  56. Yu JU. Systematic approach for the management of patients with burning mouth syndrome. School of Dentistry, Seoul National University. 2009;2:45. 
  57. Lee JK, Lee NH, Ha HK, Lee HY, Jung DY, Choi JY, et al. Analysis of Studies on Yukmijihwang-tang for Establishment of Evidence Based Medicine. Korean Journal of Oriental Physiology&Pathology. 2009;23(1):15-26. 
  58. Lee WY, Jeong GH. Consideration in the Interpretation of the Soyo-san Prescription. Herbal formula science. 2017;25(2):209-22.  https://doi.org/10.14374/HFS.2017.25.2.209
  59. Ju YS. Ungok Herbology. Jeonju:Woosuk publishing group. 2013:391,421,439,449, 454,459,476,481,483,564,710,716,732,980,1212,1216,1310,1330,1337,1407. 
  60. Editing Textbook of the Acupuncture. Acupuncture Points. Seoul:Jeongdam. 2020:316-35. 
  61. Kang DH, Yun YC, Kim JS, Kim WJ, Na CS. The Effect of LR3 Acupuncture on Blood Pressure and C-fos Expression in Hypertensive Rats Induced by 2K1C. Korean J Acupunct. 2002;19:47-56. 
  62. Kim SL, Hong KE, Kim YI. The Study on the Effect of Electroacupuncture at Taegye(KI3) on Anti-oxidation. Journal of Korean acupuncture & moxibustion medicine society. 2007;24(3):99-109. 
  63. Yao L, Ye Q, Liu Y, Yao S, Yuan S, Xu Q, et al. Electroacupuncture improves swallowing function in a post-stroke dysphagia mouse model by activating the motor cortex inputs to the nucleus tractus solitarii through the parabrachial nuclei. Nat Commun. 2023;14(1):810. 
  64. Wang T. OedaeBiyo-bang. Seoul:Daesung Publishing Co. 1992:47. 
  65. Park YC, Kim JB, Kook YB, Lee SD. Pharmacological and Toxicological review of Yukmijihwang-tang(Hwan). Herbal formula science. 2012;20(1):13-24.  https://doi.org/10.14374/HFS.2012.20.1.013
  66. Kim MJ, Hong KE. The effect of Ga-mee-gwui-ryong-tang and Yuk-mee ji-hwang-tang Herbal-acupuncture on the growth of mice. Journal of pharmacopuncture. 2006;9(3):105-16.  https://doi.org/10.3831/KPI.2006.9.3.105
  67. Xu J, Li P, Zheng L, Chen Q. Effect Observation of Electro-Acupuncture Anesthesia Combined with General Anesthesia in Elderly Patients Undergoing Gastrointestinal Tumor Resection. Front Surg. 2022;9:901638. 
  68. Lee JH, Kim GH. Bibliographic Study on the Tongue-Acupunccture Therapy. Journal of Haehwa Medicine. 1992;1(1):255-78. 
  69. The Journal of Korean Acupuncture & Moxibustion Society Textbook Compilation Committee. Acupuncture Medicine. Seoul:Hanmimedical Publishing Co. 2016:241-3. 
  70. Ju DG. Dangye Simbeop Buyeo. Seoul: Daesung Publishing Co. 1993:369. 
  71. Abetz LM, Savage NW. Burning mouth syndrome and psychological disorders. Aust Dent J. 2009;54:84-93.  https://doi.org/10.1111/j.1834-7819.2009.01099.x
  72. Grushka M, Bartoshuk L. Burning mouth syndrome and oral dysesthesias. The Canadian Journal of Diagnosis. 2000;6:99-109. 
  73. Nasri-Heir C, Gomes J, Heir GM, Ananthan S, Benoliel R, Teich S, et al. The role of sensory input of the chorda tympani nerve and the number of fungiform papillae in burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(1):65-72.  https://doi.org/10.1016/j.tripleo.2011.02.035
  74. Soares MS, Chimenos-Kustner E, Subira-Pifarre C, Rodriguez-de-Rivera-Campillo ME, Lopez-Lopez J. Association of burning mouth syndrome with xerostomia and medicines. Med Oral Patol Oral Cir Bucal. 2005;10(4):301-8. 
  75. Granot M, Nagler RM. Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensory complaints. J Pain. 2005;6(9):581-7. https://doi.org/10.1016/j.jpain.2005.03.010