Journal of Ginseng Research

  • 제47권6호
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  • Pages.694-705
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  • 2023
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
권호 표지
DOI QR코드

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Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modification, drug combination, and micro- or nano- delivery system

  • Qi-rui Hu (State Key Laboratory of Food Science and Resources, College of Food Science, Nanchang University) ;
  • Huan Hong (Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University) ;
  • Zhi-hong Zhang (Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University) ;
  • Hua Feng (Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University) ;
  • Ting Luo (State Key Laboratory of Food Science and Resources, College of Food Science, Nanchang University) ;
  • Jing Li (State Key Laboratory of Food Science and Resources, College of Food Science, Nanchang University) ;
  • Ze-yuan Deng (State Key Laboratory of Food Science and Resources, College of Food Science, Nanchang University) ;
  • Fang Chen (Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University)
  • 투고 : 2023.01.30
  • 심사 : 2023.07.19
  • 발행 : 2023.11.01
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초록

Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The main pharmacologically active components of ginseng are the dammarane-type ginsenosides, which have been shown to have anti-cancer, anti-inflammatory, immunoregulatory, neuroprotective, and metabolic regulatory activities. Moreover, some of ginsenosides (eg, Rh2 and Rg3) have been developed into nutraceuticals. However, the utilization of ginsenosides in clinic is restrictive due to poor permeability in cells and low bioavailability in human body. Obviously, the dammarane skeleton and glycosyls of ginsenosides are responsible for these limitations. Therefore, improving the oral bioavailability of ginsenosides has become a pressing issue. Here, based on the structures of ginsenosides, we summarized the understanding of the factors affecting the oral bioavailability of ginsenosides, introduced the methods to enhance the oral bioavailability and proposed the future perspectives on improving the oral bioavailability of ginsenosides.

키워드

과제정보

We would like to thank the following funding sources: The Academic and Technical Leaders Training Program of Major Disciplines in Jiangxi Province-Young Talents Programme (NO. 20204BCJ23025), and the Natural Science Foundation of Jiangxi Province (NO. 20224BAB206109).

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