Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Changes in deoxyhemoglobin and admission duration in carbon monoxide poisoning patients: a retrospective study

응급실로 내원한 급성 일산화탄소 중독환자에서 초기 디옥시헤모글로빈 분획의 상승이 입원기간 연장에 미치는 영향

  • Jae Gu Ji (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Yang Weon Kim (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Chul Ho Park (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Yoo Sang Yoon (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • JI-Hun Kang (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Chang Min Park (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Yundeok Jang (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine) ;
  • Sang Hyeon Park (Department of Emergency Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine)
  • 지재구 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 김양원 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 박철호 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 윤유상 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 강지훈 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 박창민 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 장윤덕 (인제대학교 의과대학 부산백병원 응급의학과) ;
  • 박상현 (인제대학교 의과대학 부산백병원 응급의학과)
  • Received : 2023.04.22
  • Accepted : 2023.06.20
  • Published : 2023.06.30
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Abstract

Purpose: The purpose of this study was to determine whether deoxyhemoglobin changes were associated with admission duration in carbon monoxide (CO)-poisoned patients. Methods: This retrospective study included 181 patients who were able to breathe by themselves after CO poisoning. Arterial blood gas analysis was performed to measure their deoxyhemoglobin levels. Their baseline characteristics and clinical outcomes during hospitalization in the emergency department (ED) were collected and compared. To assess changes in deoxyhemoglobin levels, blood samples were taken immediately after patients presented to the ED and then again after 6 hours. For statistical analysis, logistic regression was utilized to determine the effect of deoxyhemoglobin changes on admission duration. Results: The incidence rates of hypocapnia and hypoxemia at presentation after acute CO poisoning were 28.7% and 43.6%, respectively. Moreover, the magnitude of increasing deoxyhemoglobin levels in patients with hypoxemia (2.1 [1.7-3.1], p<0.001) and changes in deoxyhemoglobin levels appeared to have an impact on the length of hospitalization in the ED (odds ratio, 1.722; 95% confidence interval, 0.547-0.952; p<0.001). Conclusion: In patients with acute CO poisoning, deoxyhemoglobin levels appeared to increase in those with hypoxemia, which in turn was associated with prolonged hospitalization.

Keywords

References

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