Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Nodular scalp mass as the first presentation of pulmonary large cell neuroendocrine carcinoma: a case report

  • Hong Won Lee (Department of Plastic and Reconstructive Surgery, Daejeon Eulji Medical Center, Eulji University) ;
  • Young Joong Hwang (Department of Plastic and Reconstructive Surgery, Daejeon Eulji Medical Center, Eulji University) ;
  • Sung Gyun Jung (Department of Plastic and Reconstructive Surgery, Daejeon Eulji Medical Center, Eulji University) ;
  • In Pyo Hong (Department of Plastic and Reconstructive Surgery, Daejeon Eulji Medical Center, Eulji University)
  • Received : 2023.06.12
  • Accepted : 2023.10.09
  • Published : 2023.10.20
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Abstract

Metastasis of lung cancer to the skin is uncommon, presenting in 0.22% to 12% of lung cancer patients, and it is extremely rare for skin metastasis to be the first clinical manifestation of lung cancer. In the few cases where skin metastasis has been reported as the first sign of lung cancer, the patients were typically heavy smokers or had preexisting respiratory diseases and symptoms. This prompted clinicians to consider skin metastasis of a pulmonary malignancy. Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. LCNEC mainly metastasizes to visceral organs, such as the liver, bone, and brain, and it only shows metastasis to the skin in very rare cases. Herein, we report an unusual case of a metastatic skin lesion as the first sign of primary pulmonary LCNEC, in a 63-year-old woman with no pulmonary symptoms or personal history of smoking or pulmonary disease.

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References

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