Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Study of Simultaneous Counting of Thyroid Uptake with Quantitative Analysis of Thyroid Scans

갑상샘 스캔 정량분석을 통한 갑상샘 섭취율 동시계측법 연구

  • Jung-Soo Kim (Department of Radiological Science, Dongnam Health University) ;
  • Geun-Woo Kim (Department of Nuclear Medicine, National Police Hospital)
  • 김정수 (동남보건대학교 방사선학과) ;
  • 김근우 (국립경찰병원 핵의학과)
  • Received : 2023.09.25
  • Accepted : 2023.10.12
  • Published : 2023.10.31
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Abstract

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of images acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid uptake system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the protocol of thyroid scan test (99mTcO4 - , 370 MBq) in normal results, 99mTcO4 - was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 cm). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when using the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was statistically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thyroid disease.

Keywords

Acknowledgement

This paper is supported by the research fund of Dongnam Health University.

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