대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

파킨슨병에 동반된 수면장애의 한약 치료에 대한 임상 연구 동향 : 무작위 대조연구를 중심으로

Efficacy of Herbal Medicine on Sleep Disorders in Parkinson's Disease: A Review of Randomized Controlled Trials

  • 강지현 (대구한의대학교 부속 대구한방병원 심계내과학교실) ;
  • 백경민 (대구한의대학교 부속 대구한방병원 심계내과학교실)
  • Ji-hyeon Kang (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Oriental Hospital of Daegu Haany University) ;
  • Kyungmin Baek (Dept. of Cardiovascular and Neurologic Diseases of Korean Internal Medicine, Daegu Oriental Hospital of Daegu Haany University)
  • 투고 : 2023.08.24
  • 심사 : 2023.10.06
  • 발행 : 2023.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: This study reviewed randomized controlled trials (RCTs) investigating the efficacy of herbal medicine on sleep disorders associated with Parkinson's disease and suggests a better research process. Methods: We searched for RCTs for herbal medicine treatments for sleep disorders related to Parkinson's disease on July 31, 2023 using eight databases (PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure [CNKI], the Research Information Service System [RISS], Science ON, the Oriental Medicine Advanced Searching Integrated System [OASIS], and the Korea Citation Index [KCI]). Cochrane's risk of bias tool was used to assess the quality of the RCTs. Results: A total of 16 RCTs met all the inclusion criteria, and in most reports, the treatment group showed a significant improvement in sleep disorders compared to the control group. Total effective rate (TER), Pittsburgh Sleep Quality Index (PSQI), Unified Parkinson's Disease Rating Scale (UPDRS), TCM Symptom Score (TSS), Parkinson's Disease Sleep Scale (PDSS), etc., were used as evaluation indicators. Conclusion: Herbal medicine is a potential treatment for sleep disorders associated with Parkinson's disease. However, the selected RCTs were of poor quality, and it is necessary to perform more systematic studies.

키워드

참고문헌

  1. Korean Neurological Association. Neurology. 3rd rev. Seoul: Panmun; 2017, p. 544, 622-4. 
  2. You SY, Cho YW. Sleep Disorders in Patients with Parkinson's Disease. J Korean Sleep Res Soc 2014;11(2):45-9.  https://doi.org/10.13078/jksrs.14008
  3. Stocchi F, Barbato L, Nordera G, Berardelli A, Ruggieri S. Sleep disorders in Parkinson's disease. J Neurol 1998;245(1):S15-8.  https://doi.org/10.1007/PL00007731
  4. Gunn DG, Naismith SL, Lewis SJ. Sleep disturbances in Parkinson disease and their potential role in heterogeneity. J Geriatr Psychiatry Neurol 2010;23(2):131-7.  https://doi.org/10.1177/0891988709358591
  5. National Health Insurance Service, Health Insurance Review & Assessment Service. National Health Insurance Statistical Yearbook; 2017-21. 
  6. Ahn TB, Jeon BS. Sleep Disturbance and Sleep-related Disorders in Parkinson' Disease. J Korean Neurol Assoc 2002;20(4):365-72. 
  7. Taximaimaiti R, Luo X, Wang WP. Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease. Current Neuropharmacol 2021;19(12):2233-49.  https://doi.org/10.2174/1570159X19666210517115706
  8. Oh DJ, Park JH, Park SJ, Yun HY. A Case on Insomnia of a Parkinson Patient Treated with Hawangryeonhaedok-tang. J Int Korean Med 2015;spr:292-7. 
  9. Lee SW, Park HJ, Lee DB, Cho KH, Moon SK, Jung WS, et al. A Case of Insomnia with Pain after Discontinuation of Quetiapine Treated with Gilchogeun-dan. J Int Korean Med 2022;43(2):311-9.  https://doi.org/10.22246/jikm.2022.43.2.311
  10. Song X, Hu YY, Zhang ZW. Effect of Bushen Zhichan Decoction(补肾止颤方) Combined with Acupuncture Treating Sleep Disorders in Parkinson's Disease and Its influence on Levels of Serum Glutamate and Cystatin C. Chin Arch Tradit Chin Med 2023;41(2):71-5. 
  11. 王克先, 曹利民, 李红琴, 柴晓萍, 田苗苗. 镇肝熄风汤合黄连阿胶汤加减治疗帕金森病失眠肝肾阴虚证36例. Zhejiang J Tradit Chin Med 2022;57(12):880-1. 
  12. Pei L, Hong L, Yang YF. Effect of Yangxue Rougan Anshen Decoction(养血柔肝安神汤) on Parkinson's Disease with Sleep Disorders. Liaoning J Tradit Chin Med 2022;49(11):152-5. 
  13. Deng Y, Yuan CW, Wu Y. Clinical study of Yuyin Ningshen Decoction in the treatment of sleep disorders in Parkinson's disease. Inner Mongolia J Tradit Chin Med 2022;41(4):3-5. 
  14. 秦建婷. 针灸联合归脾汤加减治疗帕金森失眠患者临床效果分析. Chin J Clinicians 2022;50(1):124-6. 
  15. Zeng FJ, Liang G. Suanzaoren decoction combined with Yiguan decoction in the treatment of Parkinson's disease with insomnia of heart-liver blood deficiency type. Guangxi J Tradit Chin Med 2021;44(4):21-3. 
  16. 宋杰, 杨言府. 益肾宁心汤加减治疗帕金森病合并睡眠障碍临床研究. Shaanxi J Tradit Chin Med 2021;42(6):747-50. 
  17. Huo YW, Tan F, Lin DX, Jin PQ. Therapeutic effect of Guilu Erxian decoction combined with acupuncture on sleep disorders of parkinson's disease. Hebei J TCM 2019;41(9):1337-42. 
  18. Zhang L, Du SH, Yang X, Yang JM. Clinical Study of Sleep Disorder in Parkinson's Disease Patients Treated by DU's Fuzi Decoction. J Guangzhou Univ of Tradit Chin Med 2019;36(8):1142-5. 
  19. 陈晓生, 王映璇. 归脾汤加减治疗老年心脾两虚型帕金森病失眠症的临床观察. Yunnan J Tradit Chin Med and Materia Medica 2019;40(6):42-3. 
  20. Wang Y. Bushu Tongding Decoction in Treatment of Elderly Insomnia of Parkinson's Disease with Kidney Deficiency and Liver Stagnation Syndrome. ACTA Chin Med 2019;34(2):379-83. 
  21. Hu XH, Yang WY, Chen GY, Lei GH, Su CJ. Clinical Observation on Bailemian Capsule and Repetitive Transcranial Magnetic Stimulation in Treatment of Parkinson's Disease Patients with Insomnia. Chin J Integr Med on Cardio-/Cerebrovasc Dis 2017;15(19):2385-8. 
  22. Zhou R, Hu WH, Chen KL, Chen L, Huang JP. Efficacy Observation on Treating Parkinson's Disease with Insomnia（Liver and Kidney Yin Deficiency Syndrome)with Anshen Decoction Plus Pressing Ear Acupoint with Bean. J Liaoning Univ of TCM 2016;18(2):64-7. 
  23. 翁旭亮. 颤眠方治疗帕金森病失眠25例临床观察. Chin J Mod Drug Appl 2015;9(10):227-8. 
  24. 潘卫东, 刘云, 方正龙, 朱旭莹, 郭伸. 养血清脑颗粒改善帕金森病睡眠障碍疗效评价. Chin Community Dr 2012;28(36):12. 
  25. Hu YQ, Liu ZG, Ye Q, Yuan CX, Zhang Y, Gao C. Clinical Study on Shudi Pingchan Decoction Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Parkinson Disease with Sleep Disorders. Chin J Inf TCM 2021;28(05):88-93. 
  26. Oh JE. Sleep Disorders in the Elderly. Korean J Clin Geri 2015;16(2):37-43.  https://doi.org/10.15656/kjcg.2015.16.2.37
  27. Askenasy JJM. Sleep in Parkinson's disease. Acta neurologica scandinavica 1993;87(3):167-70.  https://doi.org/10.1111/j.1600-0404.1993.tb04095.x
  28. Lee IS, Won JH. A Case report of Soyangin patient with early-stage Parkinson's disease treated with Hyeongbangjihwhang-tang. J Sasang Constitut Med 2016;28(2):184-92.  https://doi.org/10.7730/JSCM.2016.28.2.184
  29. Park YG, Lee MS, Bae NY. A Case study of Soyangin patient with early-stage Parkinson's disease diagnosed as Upper wasting-thirst pattern. J Sasang Constitut Med 2015;27(1):178-88.  https://doi.org/10.7730/JSCM.2015.27.1.178
  30. Kwak JY, Kim YH, Park JH, Hong SJ, Ahn TW. A case report on Parkinson's disease Soyangin patient with abdominal pain and constipation. J Sasang Constitut Med 2016;28(3):276-85.  https://doi.org/10.7730/JSCM.2016.28.3.276
  31. Oh SD, Lim SM, Shin HS, Baek ET, Kim YT, Ra SY. The Clinical Review of Bowel disorders following Parkinson's disease. J Int Korean Med 2001;22(4):735-42. 
  32. Chae IC, Kim JY, Yoon HJ, Jeon CH. Manual Therapy on Constipation in Parkinson's Disease Patients: A Systematic Review. J Korea Chuna Manual Med Spine Nerves 2020;15(2):1-8.  https://doi.org/10.30581/jcmm.2020.15.2.1
  33. Lee SJ, Ha JB, Lew JH. A Case Study of Parkinson's Disease Patient with Anorexia and Nausea Treated with Korean-medicine Treatment including Hyangsayukgunja-tang. J Int Korean Med 2020;41(5):717-23.  https://doi.org/10.22246/jikm.2020.41.5.717
  34. Kim SW, Yang JY, Lee YJ, Cho KH, Jung WS, Kwon SW, et al. A Case of Parkinson's Disease Patient with Nausea and Vomiting Induced by Taking Levodopa. J Int Korean Med 2019;40(2):246-53.  https://doi.org/10.22246/jikm.2019.40.2.246
  35. Yang DH, Lee KY, Shin HS, Jo SH, Lim CS, Lim JH, et al. Clinical Study of Acupuncture Theraphy of Gastrointestinal Side Effect of Levodopa: Focused on idiopathic Pakinson's Disease Patients. J Acupunct Res 2010;27(6):11-21. 
  36. Lee MS, Park YG, Bae NY. A case study of a taeeumin patient with advanced Parkinson's disease having orthostatic hypotension. J Sasang Constitut Med 2016;28(2):193-204.  https://doi.org/10.7730/JSCM.2016.28.2.193
  37. Park YG, Lee MS, Bae NY. Case Study of Soyang Patient with Parkinson Disease Having Depression. J Sasang Constitut Med 2015;27(3):356-65.  https://doi.org/10.7730/JSCM.2015.27.3.356
  38. Jeong HS, Kim HR, Kim SY, Yim TB, Jin C, Kwon SW, et al. Effects of Korean Medicine on Pain in Patients with Parkinson's Diseases: A Retrospective Study. J Int Korean Med 2020;41(6):947-58.  https://doi.org/10.22246/jikm.2020.41.6.947
  39. Park JE, Kim KH, Lee S, Lee YJ, Lee JY. A Case-Study of Taeeumin Patient with Atypical Parkinsonian Disorders Having Dizziness and Gait Disturbance. J Sasang Constitut Med 2022;34(3):69-80. 
  40. Kim SR, Lee TY, Kim MS, Lee MC, Chung SJ. Use of complementary and alternative medicine by Korean patients with Parkinson's disease. Clin Neurol Neurosurg 2009;111(2):156-60.  https://doi.org/10.1016/j.clineuro.2008.09.011
  41. Kim JY, Jeon BS. Complementary and alternative medicine in Parkinson's disease patients in Korea. Curr Neurol Neurosci Rep 2012;12(6):631-2.  https://doi.org/10.1007/s11910-012-0309-0
  42. Kim IR, Kim HC, Park SJ, Park JH, Seo BI, Seo YB, et al. Bonchohak. Seoul: Yeongnimsa; 2004, p. 528-9, 531, 585, 635. 
  43. Kim ST, Lee SH, Kim BK. Effect of Kidney Tonification of Saam Acupuncture in Parkinson's Disease Mouse Model. Korean J Acupunct 2022;39(1):8-15.  https://doi.org/10.14406/acu.2022.004
  44. Association of Korean Medicine Professors for Cardiovascular and Neurological Medicine. Cardiovascular and Neurological Medicine in Korean MedicineI. reviseded. Seoul: Woori Medicine publication; 2016, p. 311. 
  45. The Korean Society of Oriental Neuropsychiatry. Clinical Practice Guideline of Korean Medicine : Insomnia Disorder; 2021. 
  46. Park KC. Herbal Medicine Treatment for Parkinson's Disease symptoms: Literature Review. Ph.D. dissertation, Dept. Acupuncture and Orient Med. SOUTH BAYLO Univ. Los Angeles, California; 2017. 
  47. Lee SH, Shin MR, Lee JH, Roh SS. Effects of water extract of Paeoniae Radix Alba on a thioacetamide induced acute liver injury rat model. J Nutr Health 2021;54(2):224-37.  https://doi.org/10.4163/jnh.2021.54.2.224
  48. Bae SH, Nam CG. Effects of Samul-tang and Constituent Herbs on a Contracted Artery of Rabbit. J Int Korean Med 2000;21(1):23-30. 
  49. Jeong HY, Kwon YJ, Park IJ, Kwon JT, Han BH, Lee SP. Effects of the Sanjoin on the Rat Brain: Focused on Serotonin, Sleeping Time, Sleep EEG and Autonomic Activity. J Korean Soc Biol Psychiatry 1997;4(1):54-9. 
  50. Hu Z, Kim CS, Oh EH, Lee MK, Eun JS, Hong JT, et al. Methanol extract of Zizyphi Spinosi Semen augments pentobarbital-induced sleep through the modification of GABAergic systems. Nat Prod Sci 2012;18(2):67-75. 
  51. Ha JH, Lee MG, Chang SM, Lee JT. In Vivo Characterization of Sedative Activities of Fossilia Mastodi OSSIS. Biol Pharm Bull 2006;29(7):1414-7.  https://doi.org/10.1248/bpb.29.1414
  52. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28(2):193-213.  https://doi.org/10.1016/0165-1781(89)90047-4
  53. Kim SJ. Recent advances in diagnosis and treatment of insomnia disorder. J Korean Neuropsychiatr Assoc 2020;59(1):2-12.  https://doi.org/10.4306/jknpa.2020.59.1.2
  54. Lee JJ. Pharmacological Treatment in Parkinson's Disease. J Korean Neurol Assoc 2019;37(4):335-44. https://doi.org/10.17340/jkna.2019.4.1