Journal of the Korean institute of surface engineering (한국표면공학회지)

The Korean Institute of Surface Engineering (한국표면공학회)
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A Study on the bioactive surface modification of PEEK intervertebral fusion cage using various coating techniques

다양한 코팅 처리에 의한 PEEK 추간체유합보형재의 생체 활성 표면에 관한 연구

  • Su-Bin Noh (Department of Healthcare Engineering, Jeonbuk National University) ;
  • Su-Zy Park (Medical Device Development Center, Osong Medical Innovation Foundation) ;
  • Mun-Hwan Lee (Medical Device Development Center, Osong Medical Innovation Foundation)
  • 노수빈 (전북대학교 헬스케어공학과) ;
  • 박수지 (오송첨단의료산업진흥재단 첨단의료기기개발지원센터) ;
  • 이문환 (오송첨단의료산업진흥재단 첨단의료기기개발지원센터)
  • Received : 2023.07.30
  • Accepted : 2023.08.17
  • Published : 2023.08.31
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Abstract

In this study, the surface of Polyetheretherketone (PEEK) disks was modified to have a hydrophilic surface by applying a coating of Polyethylene glycol (PEG), Hyaluronic acid(HA), and Poly-Dopamine(PDA). The investigation aimed to examine whether the coated surfaces showed enhanced bioactivity for orthopedic applications compared to the pure PEEK. The microstructure, surface characteristics, and wettability of PEEK coated with PEG, HA, and PDA were analyzed using scanning electron microscopy(SEM), FT-IR spectrophotometer, Roughness Measurement System, Micro-Vickers, and Contact angle measurement. The mechanical properties were analyzed using a tensile testing machine, while the MTT assay for cell activity was analyzed using a microplate reader to measure optical density. According to the SEM and FT-IR results, the composition and crystal structure of PEG, HA and PDA coated surface were verified. Also, roughness, hardness, and contact angle were all improved in the coating group compared to the pure PEEK. We checked the HepG2 cell proliferation by using MTT assay on 7th days. In MTT assay results, HepG2 cell proliferation was increased with time, at 7 days, cell viability on discs coated with PDA was significantly higher than pure PEEK, PEG, HA coated group. PDA coated PEEK exhibited the highest surface roughness, hardness, contact angle, and cell activity. The mechanical properties were not affected by the presence of the coating.

Keywords

References

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