DOI QR코드

DOI QR Code

A Comparative Study of the Brainstem Auditory-Evoked Response during Medetomidine, Propofol and Propofol-Isoflurane Anesthesia in Dogs

  • Sorin Choi (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Myeong-Yeon Lee (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Young Joo Kim (College of Veterinary Medicine, Western University of Health Sciences) ;
  • Dong-In Jung (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • Received : 2023.07.18
  • Accepted : 2023.07.31
  • Published : 2023.08.31

Abstract

Specialized hearing tests for pets are currently in demand. A brainstem auditory evoked response (BAER) test is an objective, non-invasive, and practical electrophysiological method that records electric signals from the peripheral auditory system to the brainstem when an auditory stimulation is provided. In veterinary medicine, sedation or anesthesia is essential for a successful examination. In human medicine, research has established the indications for various sedatives, anesthetics, and drugs according to the depth of anesthesia required. However, in veterinary medicine, there are very few comparative studies on propofol or isoflurane, which are the most common anesthetics used. Therefore, the present study aimed to analyze the difference in BAER test results between sedation with medetomidine, anesthesia using propofol, and inhalation anesthesia with isoflurane after propofol administration. The test was conducted on four healthy adult dogs. There was no statistically significant difference in latency, interpeak latency, or amplitude between the various drugs. The results suggest that a sedative or anesthetic for the administration of a BAER test can be selected according to the patient's needs.

Keywords

References

  1. Banks MI, Krause BM, Moran NS, Grady SM, Kakes J, Uhlrich DJ, et al. Evidence that loss of consciousness under anesthesia is not associated with impaired stimulus representation in auditory cortex. bioRxiv [Online]. 2017 [cited 2020 Nov 10]. Available from: https://doi.org/10.1101/213355. 
  2. Boly M, Faymonville ME, Peigneux P, Lambermont B, Damas P, Del Fiore G, et al. Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state. Arch Neurol 2004; 61: 233-238.  https://doi.org/10.1001/archneur.61.2.233
  3. Cohen MS, Britt RH. Effects of sodium pentobarbital, ketamine, halothane, and chloralose on brainstem auditory evoked responses. Anesth Analg 1982; 61: 338-343.  https://doi.org/10.1213/00000539-198204000-00005
  4. Crick F, Koch C. Are we aware of neural activity in primary visual cortex? Nature 1995; 375: 121-123.  https://doi.org/10.1038/375121a0
  5. Deeprose C, Andrade J, Harrison D, Edwards N. Unconscious auditory priming during surgery with propofol and nitrous oxide anaesthesia: a replication. Br J Anaesth 2005; 94: 57-62.  https://doi.org/10.1093/bja/aeh289
  6. Eger EI 2nd. Characteristics of anesthetic agents used for induction and maintenance of general anesthesia. Am J Health Syst Pharm 2004; 61 Suppl 4: S3-S10.  https://doi.org/10.1093/ajhp/61.suppl_4.S3
  7. Grasshoff C, Rudolph U, Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Curr Opin Anaesthesiol 2005; 18: 386-391.  https://doi.org/10.1097/01.aco.0000174961.90135.dc
  8. Gross JB. Relationship between awareness and middle latency auditory evoked responses during surgical anesthesia. Surv Anesthesiol 2004; 48: 103-104.  https://doi.org/10.1097/01.sa.0000119082.92230.70
  9. Kastner SBR. Injectable anaesthetics. In: Duke-Novakovski T, de Vries M, Seymour C, editors. BSAVA manual of canine and feline anaesthesia and analgesia. 3rd ed. Gloucester: BSAVA. 2016: 190-206. 
  10. Kumar A, Bhattacharya A, Makhija N. Evoked potential monitoring in anaesthesia and analgesia. Anaesthesia 2000; 55: 225-241.  https://doi.org/10.1046/j.1365-2044.2000.01120.x
  11. Laureys S, Faymonville ME, Degueldre C, Fiore GD, Damas P, Lambermont B, et al. Auditory processing in the vegetative state. Brain 2000; 123(Pt 8): 1589-1601.  https://doi.org/10.1093/brain/123.8.1589
  12. Laureys S, Faymonville ME, Peigneux P, Damas P, Lambermont B, Del Fiore G, et al. Cortical processing of noxious somatosensory stimuli in the persistent vegetative state. Neuroimage 2002; 17: 732-741.  https://doi.org/10.1006/nimg.2002.1236
  13. Lima JP, Ariga S, Velasco I, Schochat E. Effect of the ketamine/xylazine anesthetic on the auditory brainstem response of adult gerbils. Braz J Med Biol Res 2012; 45: 1244-1247.  https://doi.org/10.1590/S0100-879X2012007500144
  14. Manninen PH, Lam AM, Nicholas JF. The effects of isoflurane and isoflurane-nitrous oxide anesthesia on brainstem auditory evoked potentials in humans. Anesth Analg 1985; 64: 43-47.  https://doi.org/10.1213/00000539-198501000-00009
  15. Marshall AE. Brain stem auditory-evoked response of the nonanesthetized dog. Am J Vet Res 1985; 46: 966-973. 
  16. Merchant SR. Ototoxicity. Vet Clin North Am Small Anim Pract 1994; 24: 971-980.  https://doi.org/10.1016/S0195-5616(94)50111-6
  17. Miller LP, Walters JR, Martin DL. Post-mortem changes implicate adenine nucleotides and pyridoxal-5' -phosphate in regulation of brain glutamate decarboxylase. Nature 1977; 266: 847-848.  https://doi.org/10.1038/266847a0
  18. Miyake RS, Reis AG, Grisi S. [Sedation and analgesia for children]. Rev Assoc Med Bras (1992) 1998; 44: 56-64. Portuguese.  https://doi.org/10.1590/S0104-42301998000100012
  19. Murrell JC. Pre-anaesthetic medication and sedation. In: Duke-Novakovski T, de Vries M, Seymour C, editors. BSAVA manual of canine and feline anaesthesia and analgesia. 3rd ed. Gloucester: BSAVA. 2016: 170-189. 
  20. Myers LJ, Redding RW, Wilson S. Reference values of the brainstem auditory evoked response of methoxyflurane anesthetized and unanesthetized dogs. Vet Res Commun 1985; 9: 289-294.  https://doi.org/10.1007/BF02215152
  21. Pang DSJ. Inhalant anaesthetic agents. In: Duke-Novakovski T, de Vries M, Seymour C, editors. BSAVA manual of canine and feline anaesthesia and analgesia. 3rd ed. Gloucester: BSAVA. 2016: 207-213. 
  22. Pickrell JA, Oehme FW, Cash WC. Ototoxicity in dogs and cats. Semin Vet Med Surg Small Anim 1993; 8: 42-49. 
  23. Ros C, Soler C, Garcia de Carellan Mateo A. Comparison of the brainstem auditory evoked responses during sevoflurane or alfaxalone anaesthesia in adult cats. Vet Anaesth Analg 2017; 44: 1085-1090.  https://doi.org/10.1016/j.vaa.2016.11.007
  24. Ruebhausen MR, Brozoski TJ, Bauer CA. A comparison of the effects of isoflurane and ketamine anesthesia on auditory brainstem response (ABR) thresholds in rats. Hear Res 2012; 287: 25-29.  https://doi.org/10.1016/j.heares.2012.04.005
  25. Scheifele PM, Clark JG. Electrodiagnostic evaluation of auditory function in the dog. Vet Clin North Am Small Anim Pract 2012; 42: 1241-1257.  https://doi.org/10.1016/j.cvsm.2012.08.012
  26. Sebel PS, Ingram DA, Flynn PJ, Rutherfoord CF, Rogers H. Evoked potentials during isoflurane anaesthesia. Br J Anaesth 1986; 58: 580-585.  https://doi.org/10.1093/bja/58.6.580
  27. Sherry L, Levey E, Gillen C, Pillion JP. Effectiveness of dexmedetomidine for sedation in auditory brainstem response testing. J Early Hear Detect Interv 2017; 2: 10-16. 
  28. Sims MH. Electrodiagnostic evaluation of auditory function. Vet Clin North Am Small Anim Pract 1988; 18: 913-944.  https://doi.org/10.1016/S0195-5616(88)50090-6
  29. Sims MH, Horohov JE. Effects of xylazine and ketamine on the acoustic reflex and brain stem auditory-evoked response in the cat. Am J Vet Res 1986; 47: 102-109. 
  30. Sims MH, Moore RE. Auditory-evoked response in the clinically normal dog: early latency components. Am J Vet Res 1984; 45: 2019-2027. 
  31. Smith DI, Mills JH. Anesthesia effects: auditory brain-stem response. Electroencephalogr Clin Neurophysiol 1989; 72: 422-428.  https://doi.org/10.1016/0013-4694(89)90047-3
  32. Sohmer H, Gafni M, Chisin R. Auditory nerve and brain stem responses. Comparison in awake and unconscious subjects. Arch Neurol 1978; 35: 228-230.  https://doi.org/10.1001/archneur.1978.00500280046008
  33. Sprung J, Bourke DL, Contreras MG, Warner ME, Findlay J. Perioperative hearing impairment. Anesthesiology 2003; 98: 241-257.  https://doi.org/10.1097/00000542-200301000-00036
  34. Strain GM. Canine deafness. Vet Clin North Am Small Anim Pract 2012; 42: 1209-1224.  https://doi.org/10.1016/j.cvsm.2012.08.010
  35. Stronks HC, Aarts MC, Klis SF. Effects of isoflurane on auditory evoked potentials in the cochlea and brainstem of guinea pigs. Hear Res 2010; 260: 20-29.  https://doi.org/10.1016/j.heares.2009.10.015
  36. Webb AA. Brainstem auditory evoked response (BAER) testing in animals. Can Vet J 2009; 50: 313-318. 
  37. Wilson WJ, Mills PC. Brainstem auditory-evoked response in dogs. Am J Vet Res 2005; 66: 2177-2187. https://doi.org/10.2460/ajvr.2005.66.2177