Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Regulation of the Gene Expression of Airway MUC5AC Mucin through NF-κB Signaling Pathway by Artesunate, an Antimalarial Agent

  • Kyung-il Kim (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Rajib Hossain (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Jiho Ryu (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Hyun Jae Lee (Smith Liberal Arts College and Department of Addiction Science, Graduate School, Sahmyook University) ;
  • Choong Jae Lee (Department of Pharmacology, School of Medicine, Chungnam National University)
  • Received : 2023.03.05
  • Accepted : 2023.05.10
  • Published : 2023.09.01
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Abstract

In this study, artesunate, an antimalarial agent, was investigated for its potential effect on the gene expression of airway MUC5AC mucin. The human pulmonary epithelial NCI-H292 cells were pretreated with artesunate for 30 min and then stimulated with phorbol 12-myristate 13-acetate (PMA), for the following 24 h. The effect of artesunate on PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was also examined. Artesunate inhibited the glycoprotein production and mRNA expression of MUC5AC mucins, induced by PMA through the inhibition of degradation of inhibitory kappa Bα (IkBα) and NF-kB p65 nuclear translocation. These results suggest artesunate suppresses the gene expression of mucin through regulation of NF-kB signaling pathway, in human pulmonary epithelial cells.

Keywords

Acknowledgement

This research was supported by NRF-2014R1A6A1029617 Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education.

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