Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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In vivo Trafficking of Liposomes Containing Boron Compounds for Boron Neutron Capture Therapy (BNCT)

  • Huu Bao Nguyen (Department of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University) ;
  • Jeongsoo Yoo (Department of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University)
  • Received : 2023.06.07
  • Accepted : 2023.06.13
  • Published : 2023.06.30
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Abstract

For over 50 years, boron neutron capture therapy (BNCT) has been steadily developed for treating various cancers. This is a non-invasive, selective, and targeted radiotherapy wherein boron-rich molecules accumulate at the tumor site. Liposomal vesicles have become a popular and effective drug delivery system for BNCT, with strategies including surface decoration, bilayer integration, and hydrophilic core encapsulation. This review highlights the state-of-the-art uses of liposomes in BNCT and elucidates a new perspective where BNCT can be used with radiotracer guidance in all-in-one delivery systems.

Keywords

Acknowledgement

This work was supported by the R&D program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (No.2022M2E7A2019023, 2019M2D3A2060217, and RS-2022-00197770).

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