Nutrition Research and Practice

  • 제17권4호
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  • Pages.780-788
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  • 2023
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Famine exposure in early life and type 2 diabetes in adulthood: findings from prospective studies in China

  • Feng Ning (Qingdao Centers for Disease Control and Prevention) ;
  • Jing Zhao (School of Public Health, Guangzhou Medical University) ;
  • Lei Zhang (Department of Endocrine and Diabetes, Weifang Medical College) ;
  • Weijing Wang (Department of Epidemiology and Health Statistics, Qingdao University Medical College) ;
  • Xiaohui Sun (Qingdao Centers for Disease Control and Prevention) ;
  • Xin Song (Qingdao Centers for Disease Control and Prevention) ;
  • Yanlei Zhang (Department of Public Health, University of Helsinki) ;
  • Hualei Xin (Qingdao Centers for Disease Control and Prevention) ;
  • Weiguo Gao (Department of Endocrine and Diabetes, Weifang Medical College) ;
  • Ruqin Gao (Qingdao Centers for Disease Control and Prevention) ;
  • Dongfeng Zhang (Department of Epidemiology and Health Statistics, Qingdao University Medical College) ;
  • Zengchang Pang (Qingdao Centers for Disease Control and Prevention)
  • 투고 : 2022.04.04
  • 심사 : 2023.01.09
  • 발행 : 2023.08.01
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초록

BACKGROUND/OBJECTIVES: This study examined the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood during the 1959-1961 Chinese Famine. SUBJECTS/METHODS: A total of 3,418 individuals aged 35-74 years free of diabetes from two studies in 2006 and 2009 were followed up prospectively in 2009 and 2012, respectively. Famine exposure was classified as unexposed (individuals born in 1962-1978), fetal exposed (individuals born in 1959-1961), child exposed (individuals born in 1949-1958), and adolescent/adult exposed (born in 1931-1948). A logistic regression model was used to assess the relationship between famine exposure and diabetes after adjustment for potential covariates. RESULTS: During a three-year follow-up, the age-adjusted incidence rates of type 2 diabetes were 5.7%, 14.5%, 12.7%, and 17.8% in unexposed, fetal-exposed, child-exposed, and adolescent/adult-exposed groups, respectively (P < 0.01). Relative to the unexposed group, the relative risks (95% confidence interval) for diabetes were 2.15 (1.29-3.60), 1.53 (0.93-2.51), and 1.65 (0.75-3.63) in the fetal-exposed, child-exposed, and adolescent/adult-exposed groups, after controlling for potential covariates. The interactions between famine exposure and obesity, education level, and family history of diabetes were not observed, except for the urbanization type. Individuals living in rural areas with fetal and childhood famine exposure were at a higher risk of type 2 diabetes, with relative risks of 8.79 (1.82-42.54) and 2.33 (1.17-4.65), respectively. CONCLUSIONS: These findings indicate that famine exposure in early life is an independent predictor of type 2 diabetes, particularly in women. Early identification and intervention may help prevent diabetes in later life.

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과제정보

We would like to express our sincere thanks to the local research teams from Qingdao Centers for Disease Prevention and Control, and Qingdao Endocrine and Diabetes Hospital, Qingdao, China.

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