Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
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Isoegomaketone Ameliorates Atopic Dermatitis via MAPK and STAT Pathway-based Pro-Inflammatory Cytokine Regulation

  • ChangHyun Jin (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Ye-Ram Kim (Department of Pathology and Immunology, Washington University School of Medicine) ;
  • JaeYoung Shin (Institute of Health Science, Jeonju University) ;
  • ByoungOk Cho (Institute of Health Science, Jeonju University) ;
  • Ah-Reum Han (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • Received : 2023.12.19
  • Accepted : 2023.12.22
  • Published : 2023.12.31
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Abstract

Isoegomaketone(IK), isolated from the radiation-induced mutant cultivar of Perilla frutescens var. crispa, is a major phytochemical compound that has attracted attention in pharmacological research. In this study, we demonstrated that IK exerts anti-inflammatory and protective effects on human mast cells and in an atopic dermatitis mouse model. IK inhibited tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and IL-8 expression in human mast cells (HMC-1) stimulated with phorbol myristate acetate(PMA) and calcium ionophore A23187 (PMACI). IK significantly reduced the PMACI-induced phosphorylation of ERK and JNK, but not p38. IK also inhibited the PMACI-induced phosphorylation of STAT1 and STAT3. Oral administration of IK in atopic dermatitis mouse model ameliorated skin inflammation severity, as measured by skin thickness and pro-inflammatory cytokine levels such as TNF-α, IL-8, IL-4, and IL-13. These results might suggest that IK is a potent therapeutic agent against skin inflammation and atopic dermatitis.

Keywords

Acknowledgement

This research was supported by the research program of Korea Atomic Energy Research Institute (Project No. 523310-23).

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