Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Anti-Obesity Effects of Menthae Herba Hydrosol on High-Fat Diet Induced Obese Mice

고지방 식이로 유도된 비만 생쥐에서 박하 Hydrosol의 항비만 효과

  • Soo-Min Choi (Department of Korean Medicine Rehabiliation, College of Korean Medicine, Daegu Haany University) ;
  • So-Young Kim (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Young-Jun Kim (Department of Korean Medicine Rehabiliation, College of Korean Medicine, Daegu Haany University) ;
  • Chang-Hoon Woo (Department of Korean Medicine Rehabiliation, College of Korean Medicine, Daegu Haany University) ;
  • Mi-Ryeo Kim (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Hee-Duk An (Department of Korean Medicine Rehabiliation, College of Korean Medicine, Daegu Haany University)
  • 최수민 (대구한의대학교 한의과대학 한방재활의학과교실) ;
  • 김소영 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김영준 (대구한의대학교 한의과대학 한방재활의학과교실) ;
  • 우창훈 (대구한의대학교 한의과대학 한방재활의학과교실) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 안희덕 (대구한의대학교 한의과대학 한방재활의학과교실)
  • Received : 2023.06.20
  • Accepted : 2023.07.09
  • Published : 2023.07.31
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Abstract

Objectives We investigated anti-obesity effects of Menthae Herba hydrosol in obese mice. Methods Animals were divided into four groups, and treatments were performed for 7 weeks. After the treatment, serum lipid profiles, weight and pathological morphology in liver, kidney, adipose tissue were measured. Also, hepatic protein and gene expression levels of lipid metabolism-related factors were analyzed. Results Body weight was decreased in P3% group. In P1% (group fed high-fat diet and 1% Menthae Herba hydrosol) and P3% (group fed high-fat diet and 3% Menthae Herba hydrosol) group, weight of white adipose tissue, serum levels of triglyceride and blood urea nitrogen were decreased, and weight of muscle was increased. Also, liver, kidney and epididymal adipocyte size were reduced in P1% and P3% group. Adenosine monophosphate-activated protein kinase was increased and sterol regulatory element binding protein-1c (SREBP-1c) was decreased in P3% group. mPeroxisome proliferator-activator receptor-γ, mMonocyte chemotactic protein-1 were decreased in P1% and P3% group. In P3% group, mSREBP-1c was decreased and mCarnitine palmitoyl transferase-1 was increased. And mUncoupling protein 1 in brown adipose tissue was increased. Conclusions These results suggest that Menthae Herba hydrosol has a worthy effect on anti-obesity.

Keywords

References

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