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Is High Plasma Homocysteine a Direct Cause of Cardiovascular Disease and Mortality?

  • Kyung-Kuk Hwang (Division of Cardiology, Department of Internal Medicine, Chungbuk National University College of Medicine)
  • Received : 2023.07.21
  • Accepted : 2023.08.01
  • Published : 2023.10.01

Abstract

Keywords

References

  1. McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-28.
  2. Stampfer MJ, Malinow MR. Can lowering homocysteine levels reduce cardiovascular risk? N Engl J Med 1995;332:328-9.
  3. Arafa A, Lee HH, Eshak ES, et al. Modifiable risk factors for cardiovascular disease in Korea and Japan. Korean Circ J 2021;51:643-55.
  4. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-50.
  5. Bowden J, Holmes MV. Meta-analysis and Mendelian randomization: a review. Res Synth Methods 2019;10:486-96.
  6. Choi CK, Kweon SS, Lee YH, et al. Association between plasma homocysteine level and mortality: a Mendelian randomization study. Korean Circ J 2023;53:710-9.
  7. Fan R, Zhang A, Zhong F. Association between homocysteine levels and all-cause mortality: a dose-response meta-analysis of prospective Studies. Sci Rep 2017;7:4769.
  8. Clarke R, Halsey J, Lewington S, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med 2010;170:1622-31.
  9. Marti-Carvajal AJ, Sola I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev 2017;8:CD006612.
  10. Wang X, Chen Z, Tian W, et al. Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: a Mendelian randomization study. Front Cardiovasc Med 2023;10:1030257.