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The Obesity Paradox: An Epiphenomenon vs. A Clue for the Hidden Pathophysiology of Adiposity

  • In-Chang Hwang (Cardiovascular Center, Seoul National University Bundang Hospital)
  • Received : 2023.10.17
  • Accepted : 2023.10.20
  • Published : 2023.12.01

Abstract

Keywords

References

  1. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 1999;55:1560-7. https://doi.org/10.1046/j.1523-1755.1999.00389.x
  2. Gruberg L, Weissman NJ, Waksman R, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 2002;39:578-84. https://doi.org/10.1016/S0735-1097(01)01802-2
  3. Hwang IC, Choi HM, Yoon YE, et al. Body mass index, muscle mass, and all-cause mortality in patients with acute heart failure: the obesity paradox revisited. Int J Heart Fail 2022;4:95-109. https://doi.org/10.36628/ijhf.2022.0007
  4. Lim C, Won H, Ko YG, et al.; K-VIS Investigators. Association between body mass index and clinical outcomes of peripheral artery disease after endovascular therapy: data from K-VIS ELLA registry. Korean Circ J 2021;51:696-707. https://doi.org/10.4070/kcj.2021.0040
  5. Horwich TB, Fonarow GC, Hamilton MA, MacLellan WR, Woo MA, Tillisch JH. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol 2001;38:789-95. https://doi.org/10.1016/S0735-1097(01)01448-6
  6. Banack HR, Kaufman JS. Does selection bias explain the obesity paradox among individuals with cardiovascular disease? Ann Epidemiol 2015;25:342-9. https://doi.org/10.1016/j.annepidem.2015.02.008
  7. Valenzuela PL, Carrera-Bastos P, Castillo-Garcia A, Lieberman DE, Santos-Lozano A, Lucia A. Obesity and the risk of cardiometabolic diseases. Nat Rev Cardiol 2023;20:475-94. https://doi.org/10.1038/s41569-023-00847-5
  8. Choi SH, Ku EJ, Hong ES, et al. High serum adiponectin concentration and low body mass index are significantly associated with increased all-cause and cardiovascular mortality in an elderly cohort, "adiponectin paradox": the Korean Longitudinal Study on Health and Aging (KLoSHA). Int J Cardiol 2015;183:91-7. https://doi.org/10.1016/j.ijcard.2015.01.057
  9. Antonopoulos AS, Tousoulis D. The molecular mechanisms of obesity paradox. Cardiovasc Res 2017;113:1074-86. https://doi.org/10.1093/cvr/cvx106
  10. Kim BG, Kim BK, Lee YJ, et al. Association between body mass index and clinical outcomes according to diabetes in patients who underwent percutaneous coronary intervention. Korean Circ J 2023;53:843-54. https://doi.org/10.4070/kcj.2023.0159