The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Study on the Anti-Inflammatory Effect and Improvement of Dyslipidemia on Hyangsapyeongwi-san

향사평위산의 항염증 효과 및 이상지질혈증 개선 작용에 대한 연구

  • Han-nah Chae (Dept. of Internal Medicine, College of Korean Medicine, Wonkwang University) ;
  • Se-eun Chun (Dept. of Internal Medicine, Wonkwang University Jeonju Korean Medicine Hospital) ;
  • Yong-jeen Shin (Dept. of Internal Medicine, College of Korean Medicine, Wonkwang University)
  • 채한나 (원광대학교 한의과대학 내과학교실) ;
  • 천세은 (원광대학교 전주한방병원 내과학교실) ;
  • 신용진 (원광대학교 한의과대학 내과학교실)
  • Received : 2023.05.31
  • Accepted : 2023.06.27
  • Published : 2023.06.30
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Abstract

Objectives: This study aims to investigate the anti-inflammatory effect and improvement of dyslipidemia on Hyangsapyeongwi-san. Methods: In this study, HUVEC cells were cultured and treated with Hyangsapyeongwi-san to measure intracellular KLF2, eNOS, MCP-1, ICAM-1, and VCAM-1 gene expression levels related to anti-inflammation. The weight of experimental animals administered with Hyangsapyeongwi-san was measured, blood samples were biochemically analyzed, and liver tissues were reviewed to research histological changes. Results: Gene expression levels in the cells treated with Hyangsapyeongwi-san generally showed a meaningful anti-inflammatory effect. The body weight of the experimental animals decreased, and total cholesterol, triglyceride, and LDL-cholesterol in the blood generally declined while HDL-cholesterol tended to increase. Fat accumulation between hepatocytes was also reduced after the administration of Hyangsapyeongwi-san. Conclusions: This study confirmed that Hyangsapyeongwi-san has the effect of suppressing vascular inflammatory responses through the regulation of genes involved in the vascular inflammatory process and improving dyslipidemia through the reduction of blood lipids and weight loss.

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