대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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경피적 관상동맥중재술 후 재협착 예방에 대한 한약의 효과 : 무작위배정 대조군 임상연구에 대한 체계적 문헌고찰 및 메타분석

Effect of Herbal Medicines on Preventing Restenosis After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • 허나연 (우석대학교 한의과대학 내과학교실) ;
  • 안수빈 (우석대학교 한의과대학 내과학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실) ;
  • 장인수 (우석대학교 한의과대학 내과학교실)
  • Nayeon Hur (Dept. of Internal Medicine, College of Korean Medicine, Woosuk University) ;
  • Subin Ahn (Dept. of Internal Medicine, College of Korean Medicine, Woosuk University) ;
  • Hongjun Kim (Dept. of Korean Medical Prescription, College of Korean Medicine, Woosuk University) ;
  • Insoo Jang (Dept. of Internal Medicine, College of Korean Medicine, Woosuk University)
  • 투고 : 2023.05.18
  • 심사 : 2023.07.04
  • 발행 : 2023.06.30
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초록

Objective: This study was conducted to investigate the preventive effect of herbal medicines on restenosis after percutaneous coronary intervention (PCI) by reviewing randomized controlled trials (RCTs). Methods: RCTs were searched for herbal medicine treatment after PCI using eight online databases (PubMed, CNKI, Wanfang, J-STAGE, OASIS, ScienceON, KTKP, and KISS). Studies that confirmed restenosis through coronary angiography at follow-up were selected according to the inclusion and exclusion criteria. The primary outcome was the restenosis rate, and the secondary outcome was the angina recurrence rate. Data were extracted from the final selected studies according to the research methodology and then analyzed with Review Manager 5.4.1. Study quality was assessed using Cochrane's risk-of-bias (RoB) tool. Results: Of the 252 papers obtained through the primary search, nine studies that met the selection criteria were finally selected. In these nine studies, herbal medicine combined with western medicine was used for the experimental group, and western medicine treatment was used alone for the control group. The meta-analysis result revealed that the restenosis rate and angina recurrence rate were significantly lower in the experimental group than in the control group (RR=0.34, 95% CI: 0.22-0.53, p<0.00001, I2=0% and RR=0.47, 95% CI: 0.29-0.78, p=0.004, I2=0%, respectively). Furthermore, the quality of studies assessed by Cochrane's RoB was low. Conclusions: This study showed that the combined treatment of herbal medicine and western medicine was effective in preventing restenosis and angina after PCI. As the number of papers included in this study was small, a large number of high-quality clinical studies should be considered in the future.

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과제정보

본 연구는 한국보건산업진흥원의 한의약혁신기술개발사업 지원을 받아 수행되었습니다(과제고유번호: HF23C0031).

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