Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model

  • Rahim Kocabas (Department of Biochemistry, Karamanoglu Mehmetbey University School of Medicine)
  • Received : 2022.10.06
  • Accepted : 2022.12.27
  • Published : 2023.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Background and Objectives: YKL-40 is considered to be associated with cardiovascular disease (CVD). In this study, the effect of serum 25(OH) vitamin D [25(OH)VitD] differences between groups on YKL-40 was evaluated on a hypercholesterolemia rat model. Methods: Thirty-two male rats (wistar albino) were equally divided into 4 groups. The first group was the control group; the second group was high-cholesterol (H-CH) adequate vitamin D (VitD) group (H-AdeVD). The third group was the H-CH deficient VitD group (H-DefVD), and the last group was designed with the H-CH supplement VitD (H-SupVD). The feeding process consisted of 2 stages. At the first stage (5 months), the H-DefVD group was fed on VitD deficient chow, while the other groups (control, H-AdeVD, H-SupVD) were fed on standard chow. At the second stage (3 months), the H-AdeVD and the H-SupVD groups were fed on the H-CH chow, whereas the H-DefVD group was fed on the H-CH-VitD deficient chow. Moreover, the H-SupVD group was given 100 IU/kg/day VitD along with the H-CH chow. Results: Compared with the control group, interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and YKL-40 values in the H-DefVD groups increased significantly (p<0.001, p<0.001, p=0.009, p=0.005; sequentially). Conclusion: It can be concluded that VitD can suppress the YKL-40, thus, it will prevent CVD development in rat. Therefore, further clinical studies related with human will reveal the effect of VitD and YKL-40 on CVD development.

Keywords

Acknowledgement

I thank Prof. Mehmet Akoz, MD for his help with helping.

References

  1. Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation 2019;139:e56-528.
  2. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc 2013;88:720-55.
  3. Molinari C, Morsanuto V, Polli S, Uberti F. Cooperative effects of Q10, vitamin D3, and L-arginine on cardiac and endothelial cells. J Vasc Res 2018;55:47-60.
  4. Cardoso FE, Dos Santos LD, Tenorio AP, Lopes MR, Barbosa RH. Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease. J Vasc Bras 2020;19:e20190150.
  5. Kastrup J. Can YKL-40 be a new inflammatory biomarker in cardiovascular disease? Immunobiology 2012;217:483-91.
  6. Kim HM, Lee BW, Song YM, et al. Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2012;11:84.
  7. Deng X, Zhao L, Guo C, et al. Higher serum asprosin level is associated with urinary albumin excretion and renal function in type 2 diabetes. Diabetes Metab Syndr Obes 2020;13:4341-51.
  8. Kjaergaard AD, Johansen JS, Bojesen SE, Nordestgaard BG. Role of inflammatory marker YKL-40 in the diagnosis, prognosis and cause of cardiovascular and liver diseases. Crit Rev Clin Lab Sci 2016;53:396-408.
  9. Faridvand Y, Bagherpour-Hassanlouei N, Nozari S, et al. 1, 25-Dihydroxyvitamin D3 activates apelin/APJ system and inhibits the production of adhesion molecules and inflammatory mediators in LPS-activated RAW264.7 cells. Pharmacol Rep 2019;71:811-7.
  10. Liu L, Shi Z, Ji X, et al. Adipokines, adiposity, and atherosclerosis. Cell Mol Life Sci 2022;79:272.
  11. Beveridge LA, Khan F, Struthers AD, et al. Effect of vitamin D supplementation on markers of vascular function: a systematic review and individual participant meta-analysis. J Am Heart Assoc 2018;7:e008273.
  12. Abulmeaty MM, Almajwal AM, Alam I, et al. Relationship of vitamin D-deficient diet and irisin, and their impact on energy homeostasis in rats. Front Physiol 2020;11:25.
  13. Balci T, Kocabas R, Cuce G, Akoz M. Inhibition of fatty acid binding protein 4 in obese male mice adversely affects reproductive parameters. J Reprod Infertil 2021;22:16-22.
  14. Yin K, You Y, Swier V, et al. Vitamin D protects against atherosclerosis via regulation of cholesterol efflux and macrophage polarization in hypercholesterolemic swine. Arterioscler Thromb Vasc Biol 2015;35:2432-42.
  15. Lee SH, Kim DH, Youn YN, et al. Effect of rosuvastatin on bovine pericardial aortic tissue valve calcification in a rat subdermal implantation model. Korean Circ J 2017;47:401-8.
  16. Kocabas R, Akoz M. The effects of vitamin D supplementation on healthy and hypercholesterolemic rabbits on levels of OSI and paraoxonase. Turk Biyokim Derg 2018;43:549-56.
  17. Wang JH, Keisala T, Solakivi T, Minasyan A, Kalueff AV, Tuohimaa P. Serum cholesterol and expression of ApoAI, LXRbeta and SREBP2 in vitamin D receptor knock-out mice. J Steroid Biochem Mol Biol 2009;113:222-6.
  18. Soave O, Brand CD. Coprophagy in animals: a review. Cornell Vet 1991;81:357-64.
  19. Wolf ST, Dillon GA, Alexander LM, Jablonski NG, Kenney WL. Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function. Am J Physiol Heart Circ Physiol 2022;323:490-8.
  20. Zhou Q, Han X, Li R, et al. Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function. Phytomedicine 2018;51:171-80.
  21. Akoz M, Kocabas R, Topcu C, Gurbilek M. The effects of trans-9 18:1 octadecenoic acid isomer on levels of sICAM-1, svICAM-1 and IGF-1. Turk J Biochem 2011;36:1-5.
  22. Omidian M, Mahmoudi M, Javanbakht MH, et al. Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: a randomized, placebo-controlled, double-blind clinical trial. Diabetes Metab Syndr 2019;13:2873-7. 
  23. Malyszko J, Koc-Zorawska E, Malyszko J. YKL-40, a marker of cardiovascular disease and endothelial dysfunction, in kidney transplant recipients. In: Transplantation Proceedings. Amsterdam: Elsevier Inc.; 2014. p.2651-3.
  24. Tong X, Wang D, Liu S, et al. The YKL-40 protein is a potential biomarker for COPD: a meta-analysis and systematic review. Int J Chron Obstruct Pulmon Dis 2018;13:409-18.
  25. Deng Y, Li G, Chang D, Su X. YKL-40 as a novel biomarker in cardio-metabolic disorders and inflammatory diseases. Clin Chim Acta 2020;511:40-6.
  26. Naeini AE, Moeinzadeh F, Vahdat S, Ahmadi A, Hedayati ZP, Shahzeidi S. The effect of Vitamin D administration on intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 levels in hemodialysis patients: a placebo-controlled, double-blinded clinical trial. J Res Pharm Pract 2017;6:16-20.
  27. Askin L, Tibilli H, Tanriverdi O, Turkmen S. The relationship between coronary artery disease and SIRT1 protein. North Clin Istanb 2020;7:631-5.