Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

Mendelian Randomization to Evaluate the Causal Effect of Serum Bilirubin on Atrial Fibrillation

  • Takashi Hisamatsu (Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences)
  • Received : 2023.03.22
  • Accepted : 2023.04.10
  • Published : 2023.07.01
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

Acknowledgement

I thank Barbara Garbers, PhD, from Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

References

  1. Gazzin S, Vitek L, Watchko J, Shapiro SM, Tiribelli C. A novel perspective on the biology of bilirubin in health and disease. Trends Mol Med 2016;22:758-68. https://doi.org/10.1016/j.molmed.2016.07.004
  2. Smith GD, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22. https://doi.org/10.1093/ije/dyg070
  3. Sheehan NA, Didelez V, Burton PR, Tobin MD. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med 2008;5:e177.
  4. Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet 2010;375:1634-9. https://doi.org/10.1016/S0140-6736(10)60545-4
  5. Clarke R, Peden JF, Hopewell JC, et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med 2009;361:2518-28. https://doi.org/10.1056/NEJMoa0902604
  6. Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG. Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med 2008;359:1897-908. https://doi.org/10.1056/NEJMoa0707402
  7. Millwood IY, Walters RG, Mei XW, et al. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. Lancet 2019;393:1831-42. https://doi.org/10.1016/S0140-6736(18)31772-0
  8. Hisamatsu T, Miura K, Tabara Y, et al. Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis. Eur J Prev Cardiol 2022;29:2006-14. https://doi.org/10.1093/eurjpc/zwac156
  9. Kim SW, Yang JH, Kweon SS, et al. Association between serum bilirubin and atrial fibrillation: a Mendelian randomization study. Korean Circ J 2023;53:472-9. https://doi.org/10.4070/kcj.2023.0003
  10. Kang TW, Kim HJ, Ju H, et al. Genome-wide association of serum bilirubin levels in Korean population. Hum Mol Genet 2010;19:3672-8. https://doi.org/10.1093/hmg/ddq281