Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Experimental infection of a porcine kidney cell line with hepatitis A virus

  • Dong-Hwi Kim (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Da-Yoon Kim (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Jae-Hyeong Kim (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Kyu-Beom Lim (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Joong-Bok Lee (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Seung-Yong Park (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Chang-Seon Song (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • Sang-Won Lee (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University) ;
  • In-Soo Choi (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University)
  • Received : 2023.05.10
  • Accepted : 2023.06.07
  • Published : 2023.06.30
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Abstract

The hepatitis A virus (HAV) induces severe acute liver injury and is adapted to human and monkey cell lines but not other cells. In this study, the HAV was inoculated into porcine kidney (PK-15) cells to determine its infectivity in porcine cells. The growth pattern of the HAV in PK-15 cells was compared with its growth pattern in fetal rhesus kidney (FRhK-4) cells. The growth of HAV was less efficient in PK-15 cells. In conclusion, HAV replication was verified in PK-15 cells for the first time. Further investigations will be needed to identify the HAV-restrictive mechanisms in PK-15 cells.

Keywords

Acknowledgement

This research was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Agriculture, Food, and Rural Affairs Convergence Technologies Program for Educating Creative Global Leader Program, funded by Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (grant number: 320005-04-4-SB0a0).

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