Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Quantitative Analysis of Cerebellar Cortical Degeneration Using MRI in Dogs

  • Seok-Min Lee (College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University) ;
  • A-Rim Lee (College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Young-Won Lee (College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Ho-Jung Choi (College of Veterinary Medicine, Research Institute of Veterinary Medicine, Chungnam National University)
  • Received : 2023.05.23
  • Accepted : 2023.06.12
  • Published : 2023.06.30
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Abstract

In three dogs showing cerebellar ataxia, the onset of clinical signs varied from a young age of five months to age 13 years. Qualitative magnetic resonance imaging (MRI) revealed various degrees of cerebellar atrophy, and a tentative diagnosis of cerebellar cortical degeneration was made. Quantitative analysis using the brainstem to the cerebellar cross-sectional area ratio (BS:CBM ratio) and T2-signal intensity histograms were obtained to perform an objective evaluation. These techniques have the advantage of being easy and fast to evaluate. These quantitative analyses revealed the severity of cerebellar cortical degeneration in the three dogs as mild, moderate, and severe. Dogs 2 and 3 were identified as abnormal on the relative cerebrospinal fluid (CSF) space using T2-signal intensity histograms but were normal on the BS:CBM ratio. This suggests that the T2-signal intensity histograms may have higher sensitivity than BS:CBM ratio.

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References

  1. Buijtels JJ, Kroeze EJ, Voorhout G, Schellens CJ, van Nes JJ. [Cerebellar cortical degeneration in an American Staffordshire terrier]. Tijdschr Diergeneeskd 2006; 131: 518-522. Dutch.
  2. de Lahunta A. Comparative cerebellar disease in domestic animals. Compend Contin Educ Pract Vet 1980; 8: 8-19.
  3. de Lahunta A. Diseases of the cerebellum. Vet Clin North Am Small Anim Pract 1980; 10: 91-101. https://doi.org/10.1016/S0195-5616(80)50006-9
  4. de Lahunta A. Abiotrophy in domestic animals: a review. Can J Vet Res 1990; 54: 65-76.
  5. de Lahunta A, Fenner WR, Indrieri RJ, Mellick PW, Gardner S, Bell JS. Hereditary cerebellar cortical abiotrophy in the Gordon Setter. J Am Vet Med Assoc 1980; 177: 538-541.
  6. Evans HE. Miller's anatomy of the dog. 3rd ed. Philadelphia: W.B. Saunders. 1993: 898.
  7. Hanzlicek D, Kathmann I, Bley T, Srenk P, Botteron C, Gaillard C, et al. [Cerebellar cortical abiotrophy in American Staffordshire terriers: clinical and pathological description of 3 cases]. Schweiz Arch Tierheilkd 2003; 145: 369-375. German. https://doi.org/10.1024/0036-7281.145.8.369
  8. Henke D, Bottcher P, Doherr MG, Oechtering G, Flegel T. Computer-assisted magnetic resonance imaging brain morphometry in American Staffordshire Terriers with cerebellar cortical degeneration. J Vet Intern Med 2008; 22: 969-975. https://doi.org/10.1111/j.1939-1676.2008.0138.x
  9. Higgins RJ, LeCouteur RA, Kornegay JN, Coates JR. Late-onset progressive spinocerebellar degeneration in Brittany Spaniel dogs. Acta Neuropathol 1998; 96: 97-101. https://doi.org/10.1007/s004010050865
  10. Koller WC, Glatt SL, Perlik S, Huckman MS, Fox JH. Cerebellar atrophy demonstrated by computed tomography. Neurology 1981; 31: 405-412. https://doi.org/10.1212/WNL.31.4_Part_2.405
  11. Kornegay JN. Ataxia of the head and limbs: cerebellar diseases in dogs and cats. Prog Vet Neurol 1990; 1: 255-274.
  12. Olby N, Blot S, Thibaud JL, Phillips J, O'Brien DP, Burr J, et al. Cerebellar cortical degeneration in adult American Staffordshire Terriers. J Vet Intern Med 2004; 18: 201-208. https://doi.org/10.1111/j.1939-1676.2004.tb00161.x
  13. Siso S, Navarro C, Hanzlicek D, Vandevelde M. Adult onset thalamocerebellar degeneration in dogs associated to neuronal storage of ceroid lipopigment. Acta Neuropathol 2004; 108: 386- 392. https://doi.org/10.1007/s00401-004-0902-7
  14. Speciale J, de Lahunta A. Cerebellar degeneration in a mature Staffordshire terrier. J Am Anim Hosp Assoc 2003; 39: 459-462. https://doi.org/10.5326/0390459
  15. Steinberg HS, Troncoso JC, Cork LC, Price DL. Clinical features of inherited cerebellar degeneration in Gordon setters. J Am Vet Med Assoc 1981; 179: 886-890.
  16. Steinberg HS, Van Winkle T, Bell JS, de Lahunta A. Cerebellar degeneration in Old English Sheepdogs. J Am Vet Med Assoc 2000; 217: 1162-1165. https://doi.org/10.2460/javma.2000.217.1162
  17. Tatalick LM, Marks SL, Baszler TV. Cerebellar abiotrophy characterized by granular cell loss in a Brittany. Vet Pathol 1993; 30: 385- 388. https://doi.org/10.1177/030098589303000411
  18. Thames RA, Robertson ID, Flegel T, Henke D, O'Brien DP, Coates JR, et al. Development of a morphometric magnetic resonance image parameter suitable for distinguishing between normal dogs and dogs with cerebellar atrophy. Vet Radiol Ultrasound 2010; 51: 246-253. https://doi.org/10.1111/j.1740-8261.2009.01655.x
  19. van der Merwe LL, Lane E. Diagnosis of cerebellar cortical degeneration in a Scottish terrier using magnetic resonance imaging. J Small Anim Pract 2001; 42: 409-412. https://doi.org/10.1111/j.1748-5827.2001.tb02491.x