Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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The Role of Splicing Factors in Adipogenesis and Thermogenesis

  • Yadanar Than Naing (Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School) ;
  • Lei Sun (Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School)
  • Received : 2022.12.27
  • Accepted : 2023.03.03
  • Published : 2023.05.31
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Abstract

Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid storage. New research has underlined the crucial role of splicing factors in the physiological and functional regulation of adipose tissue. By generating multiple transcripts from a single gene, alternative splicing allows for a greater diversity of the proteome and transcriptome, which subsequently influence adipocyte development and metabolism. In this review, we provide an outlook on the part of splicing factors in adipogenesis and thermogenesis, and investigate how the different spliced isoforms can affect the development and function of adipose tissue.

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References

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