Anatomy and Cell Biology

Korean Association of Anatomists (대한해부학회)
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Johannes Nathanael Lieberkühn (1711-1756): luminary eighteenth century anatomist and his illuminating discovery of intestinal glands

  • Received : 2022.10.24
  • Accepted : 2022.12.28
  • Published : 2023.03.31
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Abstract

Johannes Nathanael Lieberkühn was a prodigious anatomist whose meticulous experiments and precise detailing helped in comprehending the microscopic anatomy of digestive system during early part of eighteenth century. Notably, his inventions in the field of microscopy aptly complemented his quest for anatomical knowledge at microscopic level. He designed a reflector (Lieberkühn reflector) which enhanced the amount of focussed light leading to bright illumination of tissue specimen. He invented the solar microscope which provided excellent resolution of minute anatomical details. Lieberkühn discovered the digestive juice secreting tubular glands (glands of Lieberkühn) present at the base of intestinal villi producing epithelial invaginations (crypts of Lieberkühn). He also described the intricate juxtaposition of blood vessels in relation to a single intestinal villi. Moreover, through empirically designed experimental set up, Lieberkühn was able to demonstrate the flow of lymph from intestinal villi to collecting lymphatic vessels. Also, his grandiose collection of laboratory specimens involving vascular anatomy are a testimony of his untiring efforts in academia. His contributions were seminal in comprehending the anatomy of digestive system and paved the way for future revelations. His work unveiled the enormous scope of microanatomy in medical science and catalysed the advent of histological staining methods a century later.

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Acknowledgement

The author expresses heartfelt gratitude to all the residents and faculty members of the Department of Anatomy, All India Institute of Medical Sciences, Phulwarisharif, Patna, India for their unconditional support throughout the study. I am grateful to the authorities of All India Institute of Medical Sciences, Phulwarisharif, Patna, India for their kind cooperation during the course of this study.

References

  1. Singer C. The evolution of anatomy: a short history of anatomical and physiological discovery to Harvey. A.A. Knopf; 1925. 209 p.
  2. Haubrich WS. Lieberkuhn of the crypts of Lieberkuhn. Gastroenterology 2003;124:7.
  3. Ghosh SK. The evolution of epistemological methodologies in anatomy: from antiquity to modern times. Anat Rec (Hoboken) 2022;305:803-17. https://doi.org/10.1002/ar.24781
  4. Lucas ML, Lieberkuhn JN. De Fabrica et Action. J Physiol Biochem 2008;64:393-414; discussion 389-92. https://doi.org/10.1007/BF03174095
  5. Croft WJ. Under the microscope: a brief history of microscopy. World Scientific; 2006. p. 138.
  6. Bradbury S. The evolution of the microscope. Pergamon; 2014. p 368.
  7. Lindemann M. Medicine and society in early modern Europe. 2nd ed. Cambridge University Press; 2010. p. 112.
  8. Ashrafian H. Mathematics in medicine: the 300-year legacy of iatromathematics. Lancet 2013;382:1780.
  9. Cole FJ. A history of comparative anatomy: from Aristotle to the eighteenth century. Dover Publications; 1975. p. 524.
  10. Gill S, D'Costa G, King U. Religion in Europe: contemporary perspectives. Pharos; 1994. 213 p.
  11. Davie G, Leustean L. The Oxford handbook of religion and Europe. Oxford University Press; 2022. 820 p.
  12. Ghosh SK. Human cadaveric dissection: a historical account from ancient Greece to the modern era. Anat Cell Biol 2015;48: 153-69. https://doi.org/10.5115/acb.2015.48.3.153
  13. Hendriksen MMA. Elegant anatomy: the eighteenth-century Leiden anatomical collections. Brill; 2015. p. 262.
  14. Ghosh SK. Evolution of illustrations in anatomy: a study from the classical period in Europe to modern times. Anat Sci Educ 2015;8:175-88. https://doi.org/10.1002/ase.1479
  15. Ghosh SK, Kumar A. Marcello Malpighi (1628-1694): pioneer of microscopic anatomy and exponent of the scientific revolution of the 17th century. Eur J Anat 2018;22:433-9.
  16. Wollman AJ, Nudd R, Hedlund EG, Leake MC. From Animaculum to single molecules: 300 years of the light microscope. Open Biol 2015;5:150019.
  17. Kobayashi S, Matsushima T, Sakai T, Matsushima K, Bertalanffy H, Rutka JT. Evolution of microneurosurgical anatomy with special reference to the history of anatomy, surgical anatomy, and microsurgery: historical overview. Neurosurg Rev 2022;45:253-61. https://doi.org/10.1007/s10143-021-01597-z
  18. Szallasi A. [The Journal of Mathematics and Natural History as medical literature]. Orv Hetil 1978;119:854-6. Hungarian.
  19. Turner GL. The history of optical instruments. A brief survey of sources and modern studies. Hist Sci 1969;8:53-93. https://doi.org/10.1177/007327536900800103
  20. Ford BJ. Single lens: the story of the simple microscope. Harper & Row; 1985. 182 p.
  21. Heering P. The enlightened microscope: re-enactment and analysis of projections with eighteenth-century solar microscopes. Br J Hist Sci 2008;41(150 Pt 3):345-67. https://doi.org/10.1017/S0007087408000836
  22. Lieberkuhn JN. De valvula coli et usu processus vermicularis. Wishof; 1739. 22 p.
  23. Ghosh SK. Caspar Bauhin (1560-1624): Swiss anatomist and reformer of anatomical nomenclature. Ital J Anat Embryol 2016; 121:159-64.
  24. Pytel' AIa. [Nicolas van Tulp (1593-1674); (on the 300th anniversary of his death)]. Urol Nefrol (Mosk) 1974;0:69-70. Russian.
  25. Lieberkuhn JN. De fabrica et actione villorum intestinorum tenuium hominis. Apud C. et G.J. Wishof; 1745. 36 p.
  26. Becker KC. The world through a lens: a history of the Royal Society of London, and the discovery of the red blood cell. J Thromb Thrombolysis 2010;30:496-9. https://doi.org/10.1007/s11239-010-0521-1
  27. Friedman SG. A history of vascular surgery. 2nd ed. John Wiley & Sons; 2008. p. 240.
  28. Franco NH. Animal experiments in biomedical research: a historical perspective. Animals (Basel) 2013;3:238-73. https://doi.org/10.3390/ani3010238
  29. Ensari A, Marsh MN. Exploring the villus. Gastroenterol Hepatol Bed Bench 2018;11:181-90.
  30. Pappenheimer JR, Michel CC. Role of villus microcirculation in intestinal absorption of glucose: coupling of epithelial with endothelial transport. J Physiol 2003;553(Pt 2):561-74. https://doi.org/10.1113/jphysiol.2003.043257
  31. Kamath VG, Avadhani R. Archives of anatomy from the 17th to 21st century. Arch Med Health Sci 2016;4:135-43. https://doi.org/10.4103/2321-4848.183355
  32. Pokrovskiĭ AV, Gliantsev SP. [Selected pages of history of vascular surgery in Russia (contribution of Russian surgeons to world vascular surgery)]. Angiol Sosud Khir 2014;20:10-20. Russian.
  33. Kamath VG, Ray B, Pai SR, Avadhani R. The origin of anatomy museums. Eur J Anat 2014;18:63-7.