Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-Melanogenic Dipeptides from a Cretaceous Jinju Formation Derived from Micromonospora sp.

  • Rui Jiang (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University) ;
  • Soohyun Um (College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University) ;
  • Hyeongju Jeong (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University) ;
  • Jeongwon Seo (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University) ;
  • Min Huh (Department of Geological and Environment Sciences and Korea Dinosaur Research Center and Mudeungsan Geotourism Center, Chonnam National University) ;
  • Young Ran Kim (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University) ;
  • yuho Moon (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University)
  • Received : 2023.03.02
  • Accepted : 2023.04.07
  • Published : 2023.06.30
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Abstract

The anti-melanogenic activity of 259 actinomycete strains was tested, and based on the results for the inhibition of mushroom tyrosinase activity and the reduction in melanin content, Micromonospora sp. JCS1 and JCS7 were selected as the strains with the highest anti-melanogenic potential. The activity-guided fractionation of extracts from JCS1 and JCS7 led to the isolation of the dipeptides cyclo(ʟ-Phenyl alanine (Phe)-ʟ-Proline (Pro)) (1) and cyclo(ʟ-Tryptophan (Trp)-ʟ-Proline (Pro)) (2). These two compounds were tested for their inhibition of mushroom tyrosinase by monitoring ʟ-DOPA levels and melanin production. Cyclo(ʟ-Phe-ʟ-Pro) (1) and cyclo(ʟ-Trp-ʟ-Pro) (2) were thus confirmed to have the potential for use in functional whitening cosmetics containing actinomycete-derived secondary metabolites.

Keywords

Acknowledgement

This research was supported by the National Research Foundation of Korea (NRF) grants funded by the Republic of Korean [2021R1C1C1009609, 2022R1A4A3022401, 2021R1I1A1A01049606] and Korea Basic Science Institute under the R&D program (Project No. C230430) supervised by the Ministry of Science and ICT.

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