Clinical Nutrition Research

  • 제12권1호
  • /
  • Pages.21-28
  • /
  • 2023
  • /
  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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The Impact of Obesity Surgery on Serum Uric Acid in People With Severe Obesity: A Retrospective Study

  • Leila Vafa (Laparoscopy Research Center, Shiraz University of Medical Sciences) ;
  • Masoud Amini (Laparoscopy Research Center, Shiraz University of Medical Sciences) ;
  • Hooman Kamran (Laparoscopy Research Center, Shiraz University of Medical Sciences) ;
  • Ladan Aghakhani (Laparoscopy Research Center, Shiraz University of Medical Sciences) ;
  • Seyed Vahid Hosseini (Colorectal Research Center, Shiraz University of Medical Sciences) ;
  • Zahra Mohammadi (Laparoscopy Research Center, Shiraz University of Medical Sciences) ;
  • Neda Haghighat (Laparoscopy Research Center, Shiraz University of Medical Sciences)
  • 투고 : 2022.10.02
  • 심사 : 2023.01.06
  • 발행 : 2023.01.31
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초록

Studies indicate an association between hyperuricemia (HUA) and metabolic syndrome risk factors. On the other hand, obesity is a major modifiable and independent risk factor for HUA and gout. However, evidence concerning the effects of bariatric surgery on serum uric acid levels is limited and not completely clarified. This retrospective study was carried out with 41 patients who underwent sleeve gastrectomy (n = 26) and Roux-en-Y gastric bypass (n = 15) from September 2019 to October 2021. Anthropometric, clinical, and biochemical data, including uric acid blood urea nitrogen and creatinine fasting blood sugar (FBS), serum triglyceride (TG), and serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), were measured preoperatively and postoperative 3, 6 and 12 months. From baseline to 6 and 12 months, bariatric surgery resulted in a significant decrease in serum uric acid of patients with severe obesity (p < 0.001). The decreases in serum FBS, TG, and cholesterol of patients were significant during 6 and 12 months of follow-up (p < 0.05). However, the HDL increase of patients was not statistically significant in 6 and 12 months (p > 0.05). Besides, although patients' serum level of LDL decreased significantly during the 6 months of follow-up (p = 0.007), it was not significant after 12 months (p = 0.092). Bariatric surgery significantly reduces serum uric acid levels. Therefore, it may be an effective supplementary therapy for lowering serum uric acid concentrations in morbidly obese patients.

키워드

과제정보

The present study was supported by a grant from the Vice-chancellor for Research, Shiraz University of Medical Sciences, Iran.

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