International Journal of Stem Cells

  • 제16권4호
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  • Pages.363-375
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  • 2023
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  • 2005-3606(pISSN)
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  • 2005-5447(eISSN)
한국줄기세포학회 (Korean Society for Stem Cell Research)
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In Vivo Stem Cell Imaging Principles and Applications

  • Seongje Hong (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Dong-Sung Lee (Department of Life Sciences, University of Seoul) ;
  • Geun-Woo Bae (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Juhyeong Jeon (Department of Anatomy, College of Medicine, Chung-Ang University) ;
  • Hak Kyun Kim (Department of Life Science, Chung-Ang University) ;
  • Siyeon Rhee (Stanford Cardiovascular Institute, Stanford University School of Medicine) ;
  • Kyung Oh Jung (Department of Anatomy, College of Medicine, Chung-Ang University)
  • 투고 : 2023.04.15
  • 심사 : 2023.07.21
  • 발행 : 2023.11.30
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초록

Stem cells are the foundational cells for every organ and tissue in our body. Cell-based therapeutics using stem cells in regenerative medicine have received attracting attention as a possible treatment for various diseases caused by congenital defects. Stem cells such as induced pluripotent stem cells (iPSCs) as well as embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), and neuroprogenitors stem cells (NSCs) have recently been studied in various ways as a cell-based therapeutic agent. When various stem cells are transplanted into a living body, they can differentiate and perform complex functions. For stem cell transplantation, it is essential to determine the suitability of the stem cell-based treatment by evaluating the origin of stem, the route of administration, in vivo bio-distribution, transplanted cell survival, function, and mobility. Currently, these various stem cells are being imaged in vivo through various molecular imaging methods. Various imaging modalities such as optical imaging, magnetic resonance imaging (MRI), ultrasound (US), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have been introduced for the application of various stem cell imaging. In this review, we discuss the principles and recent advances of in vivo molecular imaging for application of stem cell research.

키워드

과제정보

This research was supported by the Chung-Ang University Research Grants in 2021 to KOJ. This research was also supported by 2022 Advanced Facility Fund of the University of Seoul to DSL.

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