Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Increased Amino Acid Absorption Mediated by Lacticaseibacillus rhamnosus IDCC 3201 in High-Protein Diet-Fed Mice

  • Hayoung Kim (Ildong Bioscience) ;
  • Jungyeon Kim (Carl R. Woese Institute for Genomic Biology, the University of Illinois at Urbana-Champaign) ;
  • Minjee Lee (Ildong Bioscience) ;
  • Hyeon Ji Jeon (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Jin Seok Moon (Ildong Pharmaceutical) ;
  • Young Hoon Jung (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Jungwoo Yang (Ildong Bioscience)
  • Received : 2022.12.11
  • Accepted : 2023.01.10
  • Published : 2023.04.28
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Abstract

The use of dietary protein products has increased with interests in health promotion, and demand for sports supplements. Among various protein sources, milk protein is one of the most widely employed, given its economic and nutritional advantages. However, recent studies have revealed that milk protein undergoes fecal excretion without complete hydrolysis in the intestines. To increase protein digestibility, heating and drying were implemented; however, these methods reduce protein quality by causing denaturation, aggregation, and chemical modification of amino acids. In the present study, we observed that Lacticaseibacillus rhamnosus IDCC 3201 actively secretes proteases that hydrolyze milk proteins. Furthermore, we showed that co-administration of milk proteins and L. rhamnosus IDCC 3201 increased the digestibility and plasma concentrations of amino acids in a high-protein diet mouse model. Thus, food supplementation of L. rhamnosus IDCC 3201 can be an alternative strategy to increase the digestibility of proteins.

Keywords

Acknowledgement

This research was performed in Ildong Bioscience and Kyungpook National University, and supported by Ildong Bioscience and Kyungpook National University Research Fund 2022.

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