DOI QR코드

DOI QR Code

Endoscopic treatment of upper gastrointestinal postsurgical leaks: a narrative review

  • Renato Medas (Gastroenterology Department, Centro Hospitalar Sao Joao) ;
  • Eduardo Rodrigues-Pinto (Gastroenterology Department, Centro Hospitalar Sao Joao)
  • Received : 2023.01.28
  • Accepted : 2023.04.01
  • Published : 2023.11.30

Abstract

Upper gastrointestinal postsurgical leaks are life-threatening conditions with high mortality rates and are one of the most feared complications of surgery. Leaks are challenging to manage and often require radiological, endoscopic, or surgical intervention. Steady advancements in interventional endoscopy in recent decades have allowed the development of new endoscopic devices and techniques that provide a more effective and minimally invasive therapeutic option compared to surgery. Since there is no consensus regarding the most appropriate therapeutic approach for managing postsurgical leaks, this review aimed to summarize the best available current data. Our discussion specifically focuses on leak diagnosis, treatment aims, comparative endoscopic technique outcomes, and combined multimodality approach efficacy.

Keywords

References

  1. Bruce J, Krukowski ZH, Al-Khairy G, et al. Systematic review of the definition and measurement of anastomotic leak after gastrointestinal surgery. Br J Surg 2001;88:1157-1168.
  2. Bemelman WA, Baron TH. Endoscopic management of transmural defects, including leaks, perforations, and fistulae. Gastroenterology 2018;154:1938-1946.
  3. Messager M, Warlaumont M, Renaud F, et al. Recent improvements in the management of esophageal anastomotic leak after surgery for cancer. Eur J Surg Oncol 2017;43:258-269.
  4. Buttar NS. Minimally invasive endoscopic approaches to manage postsurgical leaks: time to recognize the finger in the dike. Gastrointest Endosc 2021;93:1300-1303.
  5. Abou Rached A, Basile M, El Masri H. Gastric leaks post sleeve gastrectomy: review of its prevention and management. World J Gastroenterol 2014;20:13904-13910.
  6. Cai JX, Schweitzer MA, Kumbhari V. Endoscopic management of bariatric surgery complications. Surg Laparosc Endosc Percutan Tech 2016;26:93-101.
  7. Cereatti F, Grassia R, Drago A, et al. Endoscopic management of gastrointestinal leaks and fistulae: what option do we have? World J Gastroenterol 2020;26:4198-4217.
  8. Al-Kurd A, Grinbaum R, Abubeih A, et al. Not all leaks are created equal: a comparison between leaks after sleeve gastrectomy and Roux-en-Y gastric bypass. Obes Surg 2018;28:3775-3782.
  9. Souto-Rodriguez R, Alvarez-Sanchez MV. Endoluminal solutions to bariatric surgery complications: a review with a focus on technical aspects and results. World J Gastrointest Endosc 2017;9:105-126.
  10. Fabbi M, Hagens ER, van Berge Henegouwen MI, et al. Anastomotic leakage after esophagectomy for esophageal cancer: definitions, diagnostics, and treatment. Dis Esophagus 2021;34:doaa039.
  11. Iannelli A, Schneck AS, Ragot E, et al. Laparoscopic sleeve gastrectomy as revisional procedure for failed gastric banding and vertical banded gastroplasty. Obes Surg 2009;19:1216-1220.
  12. Makuuchi R, Irino T, Tanizawa Y, et al. Esophagojejunal anastomotic leakage following gastrectomy for gastric cancer. Surg Today 2019;49:187-196.
  13. Kapila S, Rozen WM, Huang T, et al. Determining between chyle leak and anastomotic leak after esophageal reconstruction: the utility of methylene blue dye. Laryngoscope 2012;122:779-780.
  14. Swinnen J, Eisendrath P, Rigaux J, et al. Self-expandable metal stents for the treatment of benign upper GI leaks and perforations. Gastrointest Endosc 2011;73:890-899.
  15. Hogan BA, Winter DC, Broe D, et al. Prospective trial comparing contrast swallow, computed tomography and endoscopy to identify anastomotic leak following oesophagogastric surgery. Surg Endosc 2008;22:767-771.
  16. Nederlof N, de Jonge J, de Vringer T, et al. Does routine endoscopy or contrast swallow study after esophagectomy and gastric tube reconstruction change patient management? J Gastrointest Surg 2017; 21:251-258.
  17. Gonzalez R, Sarr MG, Smith CD, et al. Diagnosis and contemporary management of anastomotic leaks after gastric bypass for obesity. J Am Coll Surg 2007;204:47-55.
  18. Rosenthal RJ, International Sleeve Gastrectomy Expert Panel, Diaz AA, et al. International Sleeve Gastrectomy Expert Panel Consensus Statement: best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis 2012;8:8-19.
  19. Haffejee AA. Surgical management of high output enterocutaneous fistulae: a 24-year experience. Curr Opin Clin Nutr Metab Care 2004;7:309-316.
  20. Lloyd DA, Gabe SM, Windsor AC. Nutrition and management of enterocutaneous fistula. Br J Surg 2006;93:1045-1055.
  21. Schaheen L, Blackmon SH, Nason KS. Optimal approach to the management of intrathoracic esophageal leak following esophagectomy: a systematic review. Am J Surg 2014;208:536-543.
  22. Fernandez AZ Jr, DeMaria EJ, Tichansky DS, et al. Experience with over 3,000 open and laparoscopic bariatric procedures: multivariate analysis of factors related to leak and resultant mortality. Surg Endosc 2004;18:193-197.
  23. Dasari BV, Neely D, Kennedy A, et al. The role of esophageal stents in the management of esophageal anastomotic leaks and benign esophageal perforations. Ann Surg 2014;259:852-860.
  24. Kamarajah SK, Bundred J, Spence G, et al. Critical appraisal of the impact of oesophageal stents in the management of oesophageal anastomotic leaks and benign oesophageal perforations: an updated systematic review. World J Surg 2020;44:1173-1189.
  25. van Boeckel PG, Sijbring A, Vleggaar FP, et al. Systematic review: temporary stent placement for benign rupture or anastomotic leak of the oesophagus. Aliment Pharmacol Ther 2011;33:1292-1301.
  26. Rogalski P, Swidnicka-Siergiejko A, Wasielica-Berger J, et al. Endoscopic management of leaks and fistulas after bariatric surgery: a systematic review and meta-analysis. Surg Endosc 2021;35:1067-1087.
  27. Kobara H, Mori H, Nishiyama N, et al. Over-the-scope clip system: a review of 1517 cases over 9 years. J Gastroenterol Hepatol 2019;34:22-30.
  28. Vermeulen BD, Siersema PD. Diagnosis and endoscopic treatment of esophageal leakage: a systematic review. Tech Gastrointest Endosc 2019;21:58-64.
  29. Sharaiha RZ, Kumta NA, DeFilippis EM, et al. A large multicenter experience with endoscopic suturing for management of gastrointestinal defects and stent anchorage in 122 patients: a retrospective review. J Clin Gastroenterol 2016;50:388-392.
  30. Tavares G, Tustumi F, Tristao LS, et al. Endoscopic vacuum therapy for anastomotic leak in esophagectomy and total gastrectomy: a systematic review and meta-analysis. Dis Esophagus 2021;34:doaa132.
  31. Donatelli G, Spota A, Cereatti F, et al. Endoscopic internal drainage for the management of leak, fistula, and collection after sleeve gastrectomy: our experience in 617 consecutive patients. Surg Obes Relat Dis 2021;17:1432-1439.
  32. Hallit R, Calmels M, Chaput U, et al. Endoscopic management of anastomotic leak after esophageal or gastric resection for malignancy: a multicenter experience. Therap Adv Gastroenterol 2021;14:17562848211032823.
  33. Lorenzo D, Guilbaud T, Gonzalez JM, et al. Endoscopic treatment of fistulas after sleeve gastrectomy: a comparison of internal drainage versus closure. Gastrointest Endosc 2018;87:429-437.
  34. Farnik H, Driller M, Kratt T, et al. Indication for 'Over the scope' (OTS)-clip vs. covered self-expanding metal stent (cSEMS) is unequal in upper gastrointestinal leakage: results from a retrospective head-to-head comparison. PLoS One 2015;10:e0117483.
  35. do Monte Junior ES, de Moura DT, Ribeiro IB, et al. Endoscopic vacuum therapy versus endoscopic stenting for upper gastrointestinal transmural defects: systematic review and meta-analysis. Dig Endosc 2021;33:892-902.
  36. Scognamiglio P, Reeh M, Karstens K, et al. Endoscopic vacuum therapy versus stenting for postoperative esophago-enteric anastomotic leakage: systematic review and meta-analysis. Endoscopy 2020;52:632-642.
  37. Jung CF, Hallit R, Muller-Dornieden A, et al. Endoscopic internal drainage and low negative-pressure endoscopic vacuum therapy for anastomotic leaks after oncologic upper gastrointestinal surgery. Endoscopy 2022;54:71-74.
  38. Alazmi W, Al-Sabah S, Ali DA, et al. Treating sleeve gastrectomy leak with endoscopic stenting: the Kuwaiti experience and review of recent literature. Surg Endosc 2014;28:3425-3428.
  39. El Mourad H, Himpens J, Verhofstadt J. Stent treatment for fistula after obesity surgery: results in 47 consecutive patients. Surg Endosc 2013;27:808-816.
  40. Shehab HM, Hakky SM, Gawdat KA. An endoscopic strategy combining mega stents and over-the-scope clips for the management of post-bariatric surgery leaks and fistulas (with video). Obes Surg 2016;26:941-948.
  41. Southwell T, Lim TH, Ogra R. Endoscopic therapy for treatment of staple line leaks post-laparoscopic sleeve gastrectomy (LSG): experience from a large bariatric surgery centre in New Zealand. Obes Surg 2016;26:1155-1162.
  42. van Wezenbeek MR, de Milliano MM, Nienhuijs SW, et al. A specifically designed stent for anastomotic leaks after bariatric surgery: experiences in a tertiary referral hospital. Obes Surg 2016;26:1875-1880.
  43. Sakran N, Goitein D, Raziel A, et al. Gastric leaks after sleeve gastrectomy: a multicenter experience with 2,834 patients. Surg Endosc 2013;27:240-245.
  44. Simon F, Siciliano I, Gillet A, et al. Gastric leak after laparoscopic sleeve gastrectomy: early covered self-expandable stent reduces healing time. Obes Surg 2013;23:687-692.
  45. van Halsema EE, van Hooft JE. Clinical outcomes of self-expandable stent placement for benign esophageal diseases: a pooled analysis of the literature. World J Gastrointest Endosc 2015;7:135-153.
  46. Boerlage TC, Houben GP, Groenen MJ, et al. A novel fully covered double-bump stent for staple line leaks after bariatric surgery: a retrospective analysis. Surg Endosc 2018;32:3174-3180.
  47. Hamid HK, Emile SH, Saber AA, et al. Customized bariatric stents for sleeve gastrectomy leak: are they superior to conventional esophageal stents? A systematic review and proportion meta-analysis. Surg Endosc 2021;35:1025-1038.
  48. de Moura DT, de Moura EG, Neto MG, et al. Outcomes of a novel bariatric stent in the management of sleeve gastrectomy leaks: a multicenter study. Surg Obes Relat Dis 2019;15:1241-1251.
  49. El Hajj II, Imperiale TF, Rex DK, et al. Treatment of esophageal leaks, fistulae, and perforations with temporary stents: evaluation of efficacy, adverse events, and factors associated with successful outcomes. Gastrointest Endosc 2014;79:589-598.
  50. Persson S, Rouvelas I, Kumagai K, et al. Treatment of esophageal anastomotic leakage with self-expanding metal stents: analysis of risk factors for treatment failure. Endosc Int Open 2016;4:E420-E426.
  51. Freeman RK, Ascioti AJ, Giannini T, et al. Analysis of unsuccessful esophageal stent placements for esophageal perforation, fistula, or anastomotic leak. Ann Thorac Surg 2012;94:959-964.
  52. Nedelcu M, Manos T, Cotirlet A, et al. Outcome of leaks after sleeve gastrectomy based on a new algorithm adressing leak size and gastric stenosis. Obes Surg 2015;25:559-563.
  53. Murino A, Arvanitakis M, Le Moine O, et al. Effectiveness of endoscopic management using self-expandable metal stents in a large cohort of patients with post-bariatric leaks. Obes Surg 2015;25:1569-1576.
  54. Puig CA, Waked TM, Baron TH Sr, et al. The role of endoscopic stents in the management of chronic anastomotic and staple line leaks and chronic strictures after bariatric surgery. Surg Obes Relat Dis 2014;10:613-617.
  55. Rodrigues-Pinto E, Pereira P, Sousa-Pinto B, et al. Retrospective multicenter study on endoscopic treatment of upper GI postsurgical leaks. Gastrointest Endosc 2021;93:1283-1299.
  56. Park KH, Lew D, Samaan J, et al. Comparison of no stent fixation, endoscopic suturing, and a novel over-the-scope clip for stent fixation in preventing migration of fully covered self-expanding metal stents: a retrospective comparative study (with video). Gastrointest Endosc 2022;96:771-779.
  57. Schiemer M, Bettinger D, Mueller J, et al. Reduction of esophageal stent migration rate with a novel over-the-scope fixation device (with video). Gastrointest Endosc 2022;96:1-8.
  58. Ngamruengphong S, Sharaiha R, Sethi A, et al. Fully-covered metal stents with endoscopic suturing vs. partially-covered metal stents for benign upper gastrointestinal diseases: a comparative study. Endosc Int Open 2018;6:E217-E223.
  59. Choi CW, Kang DH, Kim HW, et al. Full covered self-expandable metal stents for the treatment of anastomotic leak using a silk thread. Medicine (Baltimore) 2017;96:e7439.
  60. Sdralis EIK, Petousis S, Rashid F, et al. Epidemiology, diagnosis, and management of esophageal perforations: systematic review. Dis Esophagus 2017;30:1-6.
  61. Haito-Chavez Y, Law JK, Kratt T, et al. International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video). Gastrointest Endosc 2014;80:610-622.
  62. Baron TH, Song LM, Ross A, et al. Use of an over-the-scope clipping device: multicenter retrospective results of the first U.S. experience (with videos). Gastrointest Endosc 2012;76:202-208.
  63. Honegger C, Valli PV, Wiegand N, et al. Establishment of Over-TheScope-Clips (OTSC®) in daily endoscopic routine. United European Gastroenterol J 2017;5:247-254.
  64. Keren D, Eyal O, Sroka G, et al. Over-the-Scope Clip (OTSC) system for sleeve gastrectomy leaks. Obes Surg 2015;25:1358-1363.
  65. Hagel AF, Naegel A, Lindner AS, et al. Over-the-scope clip application yields a high rate of closure in gastrointestinal perforations and may reduce emergency surgery. J Gastrointest Surg 2012;16:2132-2138.
  66. Mercky P, Gonzalez JM, Aimore Bonin E, et al. Usefulness of overthe-scope clipping system for closing digestive fistulas. Dig Endosc 2015;27:18-24.
  67. Cai JX, Khashab MA, Okolo PI 3rd, et al. Full-thickness endoscopic suturing of staple-line leaks following laparoscopic sleeve gastrectomy. Endoscopy 2014;46 Suppl 1 UCTN:E623-E624.
  68. Bohm G, Mossdorf A, Klink C, et al. Treatment algorithm for postoperative upper gastrointestinal fistulas and leaks using combined vicryl plug and fibrin glue. Endoscopy 2010;42:599-602.
  69. Kotzampassi K, Eleftheriadis E. Tissue sealants in endoscopic applications for anastomotic leakage during a 25-year period. Surgery 2015;157:79-86.
  70. Plat VD, Bootsma BT, van der Wielen N, et al. The role of tissue adhesives in esophageal surgery, a systematic review of literature. Int J Surg 2017;40:163-168.
  71. Surace M, Mercky P, Demarquay JF, et al. Endoscopic management of GI fistulae with the over-the-scope clip system (with video). Gastrointest Endosc 2011;74:1416-1419.
  72. Vilallonga R, Himpens J, Bosch B, et al. Role of percutaneous glue treatment after persisting leak after laparoscopic sleeve gastrectomy. Obes Surg 2016;26:1378-1383.
  73. Chan SM, Auyeung KK, Lam SF, et al. Current status in endoscopic management of upper gastrointestinal perforations, leaks and fistulas. Dig Endosc 2022;34:43-62.
  74. Gutschow CA, Schlag C, Vetter D. Endoscopic vacuum therapy in the upper gastrointestinal tract: when and how to use it. Langenbecks Arch Surg 2022;407:957-964.
  75. Schorsch T, Muller C, Loske G. Endoscopic vacuum therapy of perforations and anastomotic insufficiency of the esophagus. Chirurg 2014;85:1081-1093.
  76. Laukoetter MG, Mennigen R, Neumann PA, et al. Successful closure of defects in the upper gastrointestinal tract by endoscopic vacuum therapy (EVT): a prospective cohort study. Surg Endosc 2017;31:2687-2696.
  77. Bludau M, Fuchs HF, Herbold T, et al. Results of endoscopic vacuum-assisted closure device for treatment of upper GI leaks. Surg Endosc 2018;32:1906-1914.
  78. Jung DH, Huh CW, Min YW, et al. Endoscopic vacuum therapy for the management of upper GI leaks and perforations: a multicenter retrospective study of factors associated with treatment failure (with video). Gastrointest Endosc 2022;95:281-290.
  79. Watkins JR, Farivar AS. Endoluminal therapies for esophageal perforations and leaks. Thorac Surg Clin 2018;28:541-554.
  80. Ahrens M, Schulte T, Egberts J, et al. Drainage of esophageal leakage using endoscopic vacuum therapy: a prospective pilot study. Endoscopy 2010;42:693-698.
  81. Pournaras DJ, Hardwick RH, Safranek PM, et al. Endoluminal vacuum therapy (E-Vac): a treatment option in oesophagogastric surgery. World J Surg 2018;42:2507-2511.
  82. Chon SH, Tox U, Lorenz F, et al. A novel hybrid stent with endoscopic vacuum therapy for treating leaks of the upper gastrointestinal tract. Visc Med 2021;37:403-409.
  83. Lange J, Dormann A, Bulian DR, et al. VACStent: combining the benefits of endoscopic vacuum therapy and covered stents for upper gastrointestinal tract leakage. Endosc Int Open 2021;9:E971-E976.
  84. Chon SH, Scherdel J, Rieck I, et al. A new hybrid stent using endoscopic vacuum therapy in treating esophageal leaks: a prospective single-center experience of its safety and feasibility with mid-term follow-up. Dis Esophagus 2022;35:doab067.
  85. Donatelli G, Dumont JL, Cereatti F, et al. Treatment of leaks following sleeve gastrectomy by endoscopic internal drainage (EID). Obes Surg 2015;25:1293-1301.
  86. Bouchard S, Eisendrath P, Toussaint E, et al. Trans-fistulary endoscopic drainage for post-bariatric abdominal collections communicating with the upper gastrointestinal tract. Endoscopy 2016;48:809-816.
  87. Gonzalez JM, Lorenzo D, Guilbaud T, et al. Internal endoscopic drainage as first line or second line treatment in case of postsleeve gastrectomy fistulas. Endosc Int Open 2018;6:E745-E750.
  88. Donatelli G, Dumont JL, Cereatti F, et al. Endoscopic internal drainage as first-line treatment for fistula following gastrointestinal surgery: a case series. Endosc Int Open 2016;4:E647-E651.
  89. Donatelli G, Catheline JM, Dumont JL, et al. Outcome of leaks after sleeve gastrectomy based on a new algorithm addressing leak size and gastric stenosis. Obes Surg 2015;25:1258-1260.
  90. Gjeorgjievski M, Imam Z, Cappell MS, et al. A comprehensive review of endoscopic management of sleeve gastrectomy leaks. J Clin Gastroenterol 2021;55:551-576.
  91. Hughes D, Hughes I, Khanna A. Management of staple line leaks following sleeve gastrectomy: a systematic review. Obes Surg 2019;29:2759-2772.
  92. Baretta G, Campos J, Correia S, et al. Bariatric postoperative fistula: a life-saving endoscopic procedure. Surg Endosc 2015;29:1714-1720.
  93. Campos JM, Ferreira FC, Teixeira AF, et al. Septotomy and balloon dilation to treat chronic leak after sleeve gastrectomy: technical principles. Obes Surg 2016;26:1992-1993.
  94. Manta R, Caruso A, Cellini C, et al. Endoscopic management of patients with post-surgical leaks involving the gastrointestinal tract: a large case series. United European Gastroenterol J 2016;4:770-777.
  95. Berlth F, Bludau M, Plum PS, et al. Self-expanding metal stents versus endoscopic vacuum therapy in anastomotic leak treatment after oncologic gastroesophageal surgery. J Gastrointest Surg 2019;23:67-75.
  96. Bege T, Emungania O, Vitton V, et al. An endoscopic strategy for management of anastomotic complications from bariatric surgery: a prospective study. Gastrointest Endosc 2011;73:238-244.
  97. Christophorou D, Valats JC, Funakoshi N, et al. Endoscopic treatment of fistula after sleeve gastrectomy: results of a multicenter retrospective study. Endoscopy 2015;47:988-996.
  98. Rodrigues-Pinto E, Repici A, Donatelli G, et al. International multicenter expert survey on endoscopic treatment of upper gastrointestinal anastomotic leaks. Endosc Int Open 2019;7:E1671-E1682.
  99. Rodrigues-Pinto E, Pereira P, Ribeiro A, et al. Self-expanding metal stents in postoperative esophageal leaks. Rev Esp Enferm Dig 2016; 108:133-137.
  100. van Halsema EE, Kappelle WF, Weusten BL, et al. Stent placement for benign esophageal leaks, perforations, and fistulae: a clinical prediction rule for successful leakage control. Endoscopy 2018;50:98-108.