Acknowledgement
This research was benefited by grants from the National Institutes of Health (R01AR069055, U19AG055373, P20GM109036, R01AG061917), National Natural Science Foundation of China (NSFC) (Grant No. 81902277 and 81570807), National Key R&D Program of China (Grant No. 2017YFC1001100), Natural Science Foundation of Hunan Province (S2019JJQNJJ2093), Changsha Science and technology project (kq1907153), Central South University (Grant Nos. 164990007, 2018zzts886), and Xiangya Clinical Big Data Project (xyyydsj9).
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