대한본초학회지 (The Korea Journal of Herbology)

  • 제38권4호
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  • Pages.31-43
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  • 2023
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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고려엉겅퀴(Cirsium setidens (Dunn) Nakai)의 구성성분 및생리활성에 관한 리뷰

A review on Phytochemistry and pharmacological Activities of Cirsium setidens (Dunn) Nakai

  • 조미애 (사단법인천수산약초연구회) ;
  • 김범정 (경희사이버대학교 한방건강관리학과)
  • MiAe Cho (SWM Medicinal Plant Research Corporation) ;
  • Bumjung Kim (Department of Korean Medicine and Healthcare, Kyung Hee Cyber University)
  • 투고 : 2023.05.31
  • 심사 : 2023.07.25
  • 발행 : 2023.07.30
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초록

Objectives : The objective of this study was to investigate the phytochemistry and pharmacological activities of Cirsium setidens. Methods : Domestic and international articles about Cirsium setidens were investigated. A review was perfoemed via DB searching engine such as Sci.Direct, Springer, DBpia, KISS, Google scholar, Kipris, and so on. Total 73 listed literature were classified by compound analysis and pharmacological efficacy. Results : C. setidens contains pectolinarin and its glycoside, pectolinarigenin as index compounds, and linarin, apigenin, diosmetin, scopoletin, acacetin, cirsimarin, cirsimaritin, setidenosides A and B, silymarin, hispidulin, 92 volatile compounds, and 15 fatty acids. The Pharmacological activities of C. setidens has been reported to inhibit of platelet aggregation and fat accumulation in the liver, inhibit to hepatitis, anti-cancer, antibacterial, skin improvement, hair growth, liver protection, anti-diabetic, anti-inflammatory, sedative. Also, It has been reported the effect of cholesterol-lowering and anti-obesity, neuroprotective effects, increasing human stem cell viability, inhibiting osteoclast formation and osteogenic differentiation. Conclusion : This reviews showed that C. setidens which has been traditionally used for the treatment of inflammation and hypertension, has anticancer and river protective effect, as well as hair loss and diet. In order to maximize the efficacy of C. setidens, research has also begun on the effect of processing processes such as fermentation or fine powdering and combining natural plant resources.

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참고문헌

  1. Song MJ, Kim H. Taxonomic study on Cirsium Miller (Asteraceae) in Korea based on external morphology. Korean J Pl Taxon. 2007 ; 37: 17-40. DOI: https://doi.org/10.11110/kjpt.2007.37.1.017 
  2. Yoo SK, Bae YM. Phylogenetic and Chemical Analyses of Cirsium pendulum and Cirsium setidens Inhabiting Korea. J Life Science. 2012 ; 22(8) : 1120-5. DOI: 10.5352/JLS.2012.22.8.1120 
  3. Im HE, Yoe HK, Chang SY, Han MJ. Quality characteristics of Gondregaedduck by the level of Cirsium setidens and storage. Korean J Food Culture. 2012 ; 27 : 400-6. DOI: 10.7318/KJFC/2012.27.4.400 
  4. Lee OH, Kim JH, Kim YH, Lee YJ, Lee JS, Jo JH, Kim BG, Lim JK, Lee BY. Nutritional Components and Physiological Activities of Cirsium setidens Nakai. J Korean Soc Food Sci & Nutri. 2014 ; 43 : 791-8. DOI: 10.3746/jkfn.2014.43.6.791 
  5. Park SJ, Kim, HD, Lee, YH. Validation of Analytical Method of Pectolinarin for Standardized Cirsium setidens Fine Powder by Air-Classification. J Agri Life Envir Sci. 2020 ; 32 : 407-16. DOI: https://doi.org/10.22698/jales.20200035 
  6. Nam, SH, Lee, BH, Kim, YJ. Silymarin Contents and Liver Protection Effects of Six Domestic Cultivated Thistles. Trends in Agri & Life Sci. 2018 ; 56 : 55-62. DOI:https://doi.org/10.29335/tals.2018.56.55 
  7. Santosh KK, Sudheer KM, Syed MM. Silymarin protects epidermal keratinocytes from ultraviolet radiation-induced apoptosis and DNA damage by nucleotide excision repair mechanism. PLoS ONE. 2011 ; 410. DOI: https://doi.org/10.1371/journal.pone.0021410 
  8. Jung MJ, Heo SI, Wang MH. Rat Lens Aldose Reductase inhibitory of Taraxacum mongolicum and two Cirsium species. J Applied Biological Chem. 2008 ; 51 : 302-6. UCI: G704-000470.2008.51.6.006  https://doi.org/10.3839/jabc.2008.047
  9. Lee DG, Kim HK, Park YK, Woo ER, Jeong HG, Hahm KS. Gram-positive bacteria specific properties of silybin derived from Silybum marianum. Arch Pharm Re. 2003 ; 26 : 597-600. UCI: G704-000010.2003.26.8.004  G704-
  10. Lee WB, Kwon HC, Cho OR, Lee KC, Choi SU, Baek NI, Lee KR. Phytochemical Constituens of Cirsium setidens Nakai and Their Cytotoxicity against Human Cancer Cell Lines. Archives of Pharmacal Res. 2002 ; 25 : 628-35. DOI: 10.1007/BF02976934 
  11. Nugroho A, Kim MH, Lim SC, Choi JW, Choi JS, Park HJ. Validation of High-Performance Liquid Chromatography Analysis on Phenolic Substances of Cirsium setidens and Sedative effect of Pectolinarin as the Active Principle. Natural product sci. 2011 ; 17 : 342-9. UCI: G704-001403.2011.17.4.018 
  12. Yoo YM, Nam JH, Kim MY, Choi JW, Park HJ. Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-galactosamine via an antioxidant mechanism. Biol Pharm Bull. 2008 ; 31(4) : 760-4. DOI: https://doi.org/10.1248/bpb.31.760 
  13. Jeong GH, Park EK, Kim TH. New anti-glycative flavonoids from Cirsium setidens with potent radical scavenging activities. Phytochemistry Letters. 2018 ; 26 : 115-9. DOI: https://doi.org/10.1016/j.phytol.2018.05.029 
  14. Lee SH, Jin YS, Heo TH, Shim TH, Sa JH, Choi DS, Wang MH. Composition Analysis and Antioxidative Activity from Different organs of Cirsium setidens Nakai. Korean J Food Sci Tech. 2006 ; 38 : 571-6. UCI: G704-000138.2006.38.4.018 
  15. Choi HS. Chemical Composition of the Essential Oil from Cirsium setidens. Analtical Chemistry Letters. 2015 ; 5(2) : 94-102. DOI: https://doi.org/10.1080/22297928.2015.1068132 
  16. Kim SJ, Lee JY, Choi YS, Sung JM, Jang HW. Comparison of Different Types of SPME Arrow Sorbents to Analyze Volatile Compounds in Cirsium setidens Nakai. Foods 2020 ; 9(6) : 785-95. DOI: 10.3390/foods9060785 
  17. Kang IJ, Ham SS, Chung CK, Lee SY, Oh DH, Choi KP, Do JJ. Development of fermented soysauce using Cirsium setidens Nakai and comfrey. J Korean Soc Food Sci Nutr. 1997 ; 26 : 1152-8. KMID :1134819970260061152 
  18. Ham SS, Lee SY, Oh DH, Kim SH, Hong JK. Development of beverages drinks using mountain edible herbs. J Korean Soc Food Sci Nutr. 1997 ; 26 : 92-7. http://koreascience.or.kr/article/JAKO199711 9 21349347.pdf 
  19. Chang SY, Song JH, Kwak YS, Han MJ. Quality characteristics of Gondre tofu by the level of Cirsium setidens powder and storage. Korean J Food Culture. 2012 ; 27 : 737-42. DOI: https://doi.org/10.7318/KJFC/2012.27.6.737 
  20. Sim GW, Lee BC, Kim JH, Pyo HB. Cosmetic composition containing extract of cirsium setidens. Korea Patent Abstract. 2005 ; 10-2005-0075860. DOI: https://doi.org/10.8080/1020050075860 
  21. Lee JH, Cho BY, Lee, OH, Choi SH, Jung TD, Moon SY, Choi SI, Kim JD. Stability of Ethanolic Extract from Fermented Cirsium setidens Nakai by Bioconversion during Different Storing Conditions. The Korean J Food & Nutri. 2017 ; 30 : 388-94. DOI: https://doi.org/10.9799/ksfan.2017.30.2.388 
  22. Kim DS. Enzyme food composite manufacture method using Cirsium setidens. Korea Patent Abstract. 2017 ; 10-2017-0081879. DOI: https://doi.org/10.8080/1020170081879 
  23. Lee OH, Lee JH, Shin GH, Kim JM, Oh JW, Lee SJ, Lee BJ, Park SJ. Preparation method of Fermented Cirsium setidens for inhibiting the differentiation of adipocytes by bioconversion. Korea Patent Abstract. 2017 ; 10-2015-0190041. DOI: https://doi.org/10.8080/1020150190041 
  24. Lee YH, Kim HD, Park SJ. Manufacturing method for cirsium setidens powder containing high pectorinarin. Korea Patent Abstract. 2020 ; 10-2020-0182991. DOI: https://doi.org/10.8080/1020200182991 
  25. Yoo SJ, Kwak JH, Ko IJ. A study on the composition of Cirsium setidens Nakai. The Pharmaceutical Society Of Korea, Proceedings of the Convention of the Pharmaceutical Society of Korea. 1986 ; 118. 
  26. Jeong DM, Jung HA, Choi JS. Comparative antioxidant activity and HPLC profiles of some selected Korean thistles. Arch Pharm Res. 2008 ; 31 : 28-33. DOI: 10.1007/s12272-008-1116-7 
  27. Ahn MJ, Hur SJ, Kim EH, Lee SH, Shin JS, Kim MK, Uchizono JA, Whang WK, Kim DS. Scopoletin from Cirsium setidens Increases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells. The Korean J physiol & pharmacology. 2014 ; 18 : 307-11. DOI: 10.4196/kjpp.2014.18.4.307 
  28. Lee JH, Cho YH, Cho BY, Ra MJ, Kim SY, Kang IJ, Han KC, Lee OH. Stability of Ethanolic Extract from Cirsium setidens Nakai. J Food Hygiene & Safety. 2016 ; 31 : 304-9. DOI: https://doi.org/10.13103/JFHS.2016.31.4.304 
  29. Yi TG, Son JD, Park YR, Um BH, Park NI. Changes of HPLC Pattern according to the Induction of Hairy Roots and the Treatment of Methyl Jasmonate in Cirsium setidens and C. pendulum. The Korean Society of Medicinal Crop Science. 2017 ; 82. DOI: https://db.koreascholar.com/Article/Detail/326212 
  30. Jung HJ, Han YJ, Lee DK, Gam DH, Kim JW. Optimization of alkaline hot-water extraction conditions for production of polyphenolic compounds and flavonoids from Korean thistle (Cirsium japonicum). Journal of advanced engineering and technology. 2018 ; 11 : 95-9. DOI: 10.35272/jaet.2018.11.2.95 
  31. Kim HL, Hong JW, Jeon SJ, Kim HY, Kim JW. Optimization of Ultrasound-Assisted Extraction of Antioxidant from Cirsium setidens Using Response Surface Methodology. J Korean Soc Food Sci & Nutri. 2021 ; 50 : 285-93. DOI: https://doi.org/10.3746/jkfn.2021.50.3.285 
  32. Shin SJ, Saravanakumar K, Sathiyaseelan A, Mariadoss AVA, Park SJ, Park SY, Han KS, Wang MH. Phytochemical profile and antidiabetic effect of the bioactive fraction of Cirsium setidens in streptozotocin-induced type 2 diabetic mice. Process Biochem. 2022 ; 116 : 60-71. DOI: https://doi.org/10.1016/j.procbio.2022.02.017 
  33. Oh JW, Lee JH, Cho ML, Skin GH, Kim JM, Choi SL, Jung TD, Kim YH, Lee SJ, Lee BJ, Park SJ, Lee OH. Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion. J Korean Soc Food Sci & Nutri. 2015 ; 44 : 1504-9. DOI: 10.3746/jkfn.2015.44.10.1504 
  34. Ko HJ, Kwon YS, Kim HP, Yang HJ, Song JH, Kim SR, Choi SY, Chang SY. Antiviral composition comprising Cirsium setidens Nakai extracts. Korea Patent Abstract. 2017 ; 10-2017-0077500. DOI: https://doi.org/10.8080/1020170077500 
  35. Cho CW, Choi SY, Hong HD, Rhee YK, Jeong HC. Isolation method of flavonoid from Cirsium setidens. Korea Patent Abstract. 2013 ; 10-2013-0093067. DOI: https://doi.org/10.8080/1020130093067 
  36. Mok JY, Kang HJ, Cho JK, Jeong IH, Kim HS, Park JM, Jeong SI, Shim JS, Jang SI. Antioxidative and Anti-inflammatory Effects of Extracts from Different Organs of Cirsium japonicum var. ussuriense. Kor. J. Herbology. 2011 ; 26(4) : 39-47. DOI: https://doi.org/10.6116/kjh.2011.26.4.039 
  37. Shin SJ, Saravanakumar K, Mariadoss AVA, Hu X, Sathiyaseelan A, Wang MH. Functionalization of selenium nanoparticles using the methanolic extract of Cirsium setidens and its antibacterial, antioxidant, and cytotoxicity activities. J Nanostructure in Chem. 2022 ; 12 : 23-32. DOI: 10.1007/s40097-021-00397-7 
  38. Yin HH, Cho BO, Chong ZF, Shim JS, Jang SI. Anti-Obesity Effects of Water Extracts from Different Organs of Cirsium japonicum var. ussuriense. J Physiol & Pathol Korean Med. 2015 ; 29 : 322-9. DOI: 10.15188/kjopp.2015.08.29.4.322 
  39. Cho BY, Lee JH, Choi SI, Jung TD, Choi SH, Ra MJ, Kim SY, Kang IJ, Han KC, Lee OK. Changes in Antioxidant and Antiobesity Activities of Cirsium setidens Nakai Ethanolic Extract Depending on Different Harvest Time. J. Food Hyg Saf. 2017 ; 32 : 234-42. DOI: 10.13103/JFHS.2017.32.3.234 
  40. Guo HF, Wang MH. Impact of drying method on antioxidant, anti-diabetic, and anti-proliferation activities of Cirsium setidens in vitro. Acta Alimentaria. 2018 ; 47 : 44-51. DOI: 10.1556/066.2018.47.1.6 
  41. Yoon MH, Lim CH, Oh JH, Lee JC, Choi WY. Screening of Inhibitors of Platelet Aggregation from Edible Plants. CNU J agricultural sci. 1997 ; 24 : 267-74. https://scienceon.kisti.re.kr/srch/select PORSrchArticle.do?cn=JAKO199719959262107  107
  42. Kim EM. Antioxidant and Anticancer Effects of Extracts and Components from Artemisia princeps Pampanini and Cirsium setidens Nakai. J East Asian Soc Dietary Life. 2011 ; 21 : 871-76. UCI: G704-001333.2011.21.6.017 
  43. Kim KM, Wang MH, Shin SJ. Selenium nanoparticles using Cirsium Setidens leaf extract and its manufacturing method. Korea Patent Abstract. 2020 ; 10-2020-0155616. DOI: https://doi.org/10.8080/1020200155616 
  44. Sim GS, Kim JH, Lee DH, Lee BC, Lee GS, Pyo HB. The Inhibition of UVA-induced Matrix Metalloproteinase-1 in Human Dermal Fibroblasts and the Improvement of Skin Elasticity by Cirsium setidens Extract. J soci of cosmetic scientists of korea. 2007 ; 33 : 181-7. UCI: G704-002161.2007.33.3.010 
  45. Hur SJ, Park EY, Ann MJ, Jang AR, Yang KS, Whang WK. A Study on the Whitening Effects and HPLC Pattern analysis of Cirsium setidens Nakai. The Korean Society for Aesthetics & Cosmetology 2010 ; 8 : 203-11. UCI: G704-SER000010442.2010.8.4.031 
  46. PARK SM, LEE JO, OH SH, Kim WR. Cosmetic composition with pectolinarin for skin anti-wrinkle and anti aging. Korea Patent Abstract. 2016 ; 10-2016-0077815. DOI: https://doi.org/10.8080/1020160077815 
  47. KIM TG, Lee YJ, Choi BH, Park JE, Kim LS. LIPOSOME COMPOSITION CONTAINING CIRSIUM SETIDENS EXTRACT. Korea Patent Abstract. 2018 ; 10-2018-0160860. DOI: https://doi.org/10.8080/1020180160860 
  48. MIN GH. Cosmetic composition for improved performance of cosmetic having cosmetic maintenance. Korea Patent Abstract. 2021 ; 10-2019-0178400. DOI: https://doi.org/10.8080/1020190178400 
  49. Park DL. COMPOSITION FOR SKIN ANTI-POLUTIONCOMPRISING EXTRACT OF CIRSIUM SETIDENS AS AN EFFECTIVE INGREDIENT. Korea Patent Abstract. 2021 ; 10-2021-0016270. DOI: https://doi.org/10.8080/1020210016270 
  50. Kim WS, Sim BY, Kim DH. Effect of Natural Herb Mixture on Anti-atopic Dermatitis and Skin Regeneration. Kor. J. Herbology. 2017 ; 32 : 55-62. DOI: https://doi.org/10.6116/kjh.2017.32.6.55. 
  51. Wang MH, Lee SH, Seong ES. Effect for Hepatoprotective activities from Cirsium setidens Nakai. The Korean Soc of Medicinal Crop Sci. 2007 ; 249-50. 
  52. Lee SH, Heo SI, Li L, Lee MJ, Wang MH. Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. American J Chinese medicine. 2008 ; 36 : 107-14. DOI: 10.1142/S0192415X0800562X. 
  53. Park HJ, Yoo YM, Nam JH, Kim WB, Choi JW. Hepatoprotective composition comprising pectolinarin or pectolinarigenin. Korea Patent Abstract. 2007 ; 10-2007-0106338. DOI: https://doi.org/10.8080/1020070106338 
  54. Noh HY, Lee HJ, Kim EH, Mu L, Rhee YK, Cho CW, Chung JY. Inhibitory Effect of a Cirsium setidens Extract on Hepatic Fat Accumulation in Mice Fed a High-Fat Diet via the Induction of Fatty Acid β-Oxidation. Biosci Biotech & Biochem. 2013 ; 77 : 1424-29. DOI: 10.1271/bbb.130049 
  55. Choi JW, Cho SJ, Shin MR, Park HJ. Combined Treatment of Silymarin and Jakyakgamcho-tang Suppresses Hepatic Lipid Accumulation and Inflammation in C57BL/6 Mice. Kor. J. Herbology. 2022 ; 37 : 17-26. DOI: dx.10.6116/kjh.2022.37.5.9. 
  56. Kim EH, Chung JY. Protective effects of Cirsium setidens ethanolic extracts against alcoholic fatty liver injury in rats. J Nutri Health. 2016 ; 49 : 420-8. DOI: https://doi.org/10.4163/jnh.2016.49.6.420 
  57. Guo H, Yunyao J, Wang MH. Synergistic Antidiabetic Effect of Cirsium setidens Combined with Other Plants in vitro and in vivo. Korean J Plant Resources. 2015 ; 28 : 752-8. DOI: https://doi.org/10.7732/kjpr.2015.28.6.752 
  58. Kim TW, Lee JM, Jeong GH, Kim TH. Inhibitory effects of advanced glycation end products formation andfree radical scavenging activity of Cirsium setidens. Korean J Food Preserv. 2016 ; 23 : 283-9. DOI: https://doi.org/10.11002/kjfp.2016.23.2.283 
  59. Wang MH. Antidiabetic composition containing of cirsium setidens nakai extract method of preparing the same. Korea Patent Abstract. 2016 ; 10-2015-0161830. DOI: https://doi.org/10.8080/1020150161830 
  60. Lee SH. Jung MJ. Heo SI, Wang MH. Antiinflammatory Effect and HPLC Analysis of Extract from Edible Cirsium setidens. J. Korean Soc Appl Biol Chem. 2009 ; 52 : 437-442. UCI : G704-000111.2009.52.5.024  https://doi.org/10.3839/jksabc.2009.076
  61. Kim JE, Kim, Choi CU, Ly SY. Anti-inflammatory Effect of Cirsium Setidens Ethanol Extract on Macrophages and Effect on Immunoglobulins in Normal or Ovalbumin Sensitized Balb/c Mouse. Korean J Human Ecology. 2017 ; 575. DOI: 10.5934/kjhe.2017.26.5.575 
  62. Kim YO, Lee SW, Park CG, Ahn YS, Kim HD. A Pharmaceutical composition for preventing or treating inflammatory disease comprising and extract of Cirsium japonicum. . Korea Patent Abstract. 2016 ; 10-2016-0132267. DOI: https://doi.org/10.8080/1020160132267 
  63. Kwon HY, Choi SI, Cho BY, Choi SH, Sim WS, Xionggao H, Jang GW, Lee OK. Nitrite scavenging activity and anti-inflammatory effects of standardized Cirsium setidens extract. Korean J Food Preserv. 2019 ; 26 : 343-9. DOI: https://doi.org/10.11002/kjfp.2019.26.3.343 
  64. Heo SI, Jung SM. Immunity enhancement efficacy of the extracts prepared from blanched and dried aerial part in Cirsium setdens Nakai. Korean J. Food Preserv. 2021 ; 28 : 685-91. DOI: https://doi.org/10.11002/kjfp.2021.28.5.685 
  65. Park DL. Manufacturing method of food composition for immune-enhancing activity comprising juice of Cirsium setidens, and food composition for immune-enhancing activity using thereby. Korea Patent Abstract. 2020 ; 10-2020-0142906. DOI: https://doi.org/10.8080/1020200142906 
  66. Park DL. Method of preparation for cirsium setidens having an immune-enhancing activity with enhanced pectolinarin content, cirsium setidens having an immune-enhancing activity using thereby and food composition containing the same. Korea Patent Abstract. 2020 ; 10-2020-0119894. DOI: https://doi.org/10.8080/1020200119894 
  67. Wang MH, Park DL. Extract of Cirsium setidens Nakai for Lowering Cholesterol. Korea Patent Abstract. 2012 : 10-2012-0092836. DOI: https://doi.org/10.8080/1020120092836 
  68. Cho ML, Cho JH, Lee JS, Lee OH, Lee BY, Lee YJ, YU SY, Kim YH, Kim BK, Kim DB, Kim JH, Lee JH. Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts. Food Sci & Biotech. 2015 ; 24 : 2235-43. DOI: 10.1007/s10068-015-0298-2 
  69. Cho BY, Park MR, Lee JH, Ra MJ, Han KC, Kang IJ, Lee OH. Standardized Cirsium setidens Nakai Ethanolic Extract Suppresses Adipogenesis and Regulates Lipid Metabolisms in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets. J Med Food. 2017 ; 20 : 763-76. DOI: 10.1089/jmf.2017.3965 
  70. Kim KJ, Lee JH, Lee BY, Lee OH. Optimized Cirsium setidens Nakai Fermented by Lentinula edodes Attenuates Lipid Accumulation by Regulating Fatty Acid Oxidation-mediated Lipolysis in 3T3-L1 Cells and High Calorie Diet-induced Obese Zebrafish. J Food & Nutri Res. 2017 ; 5 : 354-61. DOI: 10.12691/jfnr-5-6-1 
  71. Cho BY, Choi SI, Choi SH, Sim WS, Ra MJ, Kim SY, Kang IJ, Han KC, Lee OK. Anti-obesity Activities of Cirsium setidens Nakai Ethanolic Extract. J Food Hyg Saf. 2018 ; 33 : 389-98. DOI:10.13103/JFHS.2018.33.5.389 
  72. Lee JW. Anti-obesity composition comprising cirsium japonicum extract as effective component. Korea Patent Abstract. 2020 ; 10-2020-0160218. DOI: https://doi.org/10.8080/1020200160218 
  73. Lee YJ, Cho JH, Kim BK, Choi HS, Lee BY, Lee OH. Cirsium setidens Nakai extract inhibits adipocyte differentiation and High-Fat Diet-induced obesity in Mice. The FASEB J. 2021 ; 27 : 637.7. DOI: https://doi.org/10.1096/fasebj.27.1_supplement.637.7 
  74. Park SJ, Kim HD, Lee YH. Antioxidant and Anti-Obesity Properties of Pectolinarin-rich Cirsium setidens Nakai Fine Powder. Korean J. Food Nutr. 2021 ; 34 : 69-78. DOI: https://doi.org/10.9799/ksfan.2021.34.1.069 
  75. Choi SI, Han X, Men SX, Lee SJ, Park KT, Han JK, Lee OK. Standardized pectolinarin rich-Cirsium setidens Nakai extract attenuates bisphenol A-induced the 3T3-L1 adipocytes differentiation and obese C57BL/6J mice via the suppression of adipogenesis-related transcription factors. J Functional Foods. 2022 ; 95 : 1-8. DOI: 10.1016/j.jff.2022.105146 
  76. Bae JS, Pyun CW, An JH, Jeon YJ, Park JE, Son IG. Multifunctional food complex composition for preventing or improving obesity comprising essentially Cirsium setidens and barley sprout extracts, and preparing method thereof. Korea Patent Abstract. 2019 ; 10-2019-0151469. DOI: https://doi.org/10.8080/1020190151469 
  77. Bae JS, Pyun CW, Seo TS, Jeon YJ, An JH, Park JE, Son IG. Anti-oxidant and Anti-obesity composition comprising Complex the extract of Allium senescens L. and crisium setidens as the effient composition. Korea Patent Abstract. 2021 ; DOI: 10-2021-0189302. https://doi.org/10.8080/1020210189302 
  78. Kwon KH, Lim H, Chung MJ. Neuroprotective Effects of Bread Containing Cirsium setidens or Aster scaber. J Korean Soc Food Sci Nutr. 2014 ; 43 : 829-35. DOI: https://doi.org/10.3746/jkfn.2014.43.6.829 
  79. Chung MJ, Park YI, Kwon KH. Neuroprotective Effects of Cirsium setidens, Pleurospermum kamtschaticumin, and Allium victorials Based on Antioxidant and p38 Phosphorylation Inhibitory Activities in SK-N-SH Neuronal Cells. J Korean Society of Food Sci & Nutr. 2015 ; 44 : 347-55. DOI: https://doi.org/10.3746/jkfn.2015.44.3.347 
  80. Chung MJ, Lee S, Park YI, Lee J, Kwon KH. Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells. Life Sciences. 2016 ; 173. DOI: 10.1016/j.lfs.2016.02.035 
  81. Lee JH, Jung HK, Han YS, Yoon YM, Yuj CW, Sun HY, Cho HW, Lee SH. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Molecular Medicine Reports. 2016 ; 14 : 3777-84. DOI: https://doi.org/10.3892/mmr.2016.5706 
  82. Kim HB, Cheong KM, Seo YR, Lim KT. Effects of Cirsium setidens nakai on In Vitro Growth and Osteogenic Differentiation of Human Bone-Derived Mesenchymal Stem Cells. Korean Society for Agricultural Machinery. 2017 ; 109. DOI: https://www.dbpia.co.kr/Journal/articleDetail?nodeId=NODE09861747 
  83. Sayan DD, Dinesh KP, Jin B, Choi SI, Lee OH, Lim KT. Effects of Cirsium setidens (Dunn) Nakai on the osteogenic differentiation of stem cells. Molecular Medicine Reports. 2021 ; 23 : 1-11. DOI: https://doi.org/10.3892/mmr.2021.11903 
  84. LIM KT, Lee OH. A Composition for Promote Osteogenic Differentiation of Stem Cells comprising extract from Cirsium setidens (Dunn) Nakai. Korea Patent Abstract. 2020 ; 10-2020-0153666. DOI: https://doi.org/10.8080/1020200153666 
  85. Kim Si, Kang YH. Cirsium Setidens Extracts Abrogate Actin Ring Formation and Bone-Resorbing Osteoclasts Through Inhibition of Core-Linked CD44 and Diffuse Cloud-Associated αvβ 3 Integrin. Curr Dev Nutr. 2020 ; 4 : 416. DOI: 10.1093/cdn/nzaa045_049 
  86. Ko HJ, Kwon YS, Kim HP, Yang HJ, Song JH, Kim SR, Choi SY, Chang SY. Antiviral composition comprising Cirsium setidens Nakai extracts. Korean Patent Abstract. 2018 ; 10-2018-0107400. DOI: https://doi.org/10.8080/1020180107400