Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
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Potential clinical utility of intraoperative fluid amylase measurement during pancreaticoduodenectomy

  • Kunal Joshi (Liver Unit, Queen Elizabeth Hospital) ;
  • Manuel Abradelo (Liver Unit, Queen Elizabeth Hospital) ;
  • David Christopher Bartlett (Liver Unit, Queen Elizabeth Hospital) ;
  • Nikolaos Chatzizacharias (Liver Unit, Queen Elizabeth Hospital) ;
  • Bobby Venkata Dasari (Liver Unit, Queen Elizabeth Hospital) ;
  • John Isaac (Liver Unit, Queen Elizabeth Hospital) ;
  • Ravi Marudanayagam (Liver Unit, Queen Elizabeth Hospital) ;
  • Darius Mirza (Liver Unit, Queen Elizabeth Hospital) ;
  • Keith Roberts (Liver Unit, Queen Elizabeth Hospital) ;
  • Robert Peter Sutcliffe (Liver Unit, Queen Elizabeth Hospital)
  • Received : 2022.09.14
  • Accepted : 2022.12.10
  • Published : 2023.05.31
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Abstract

Backgrounds/Aims: Postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) is a source of major morbidity and mortality. Early diagnosis and treatment of POPF is mandatory to improve patient outcomes and clinical risk scores may be ombined with postoperative drain fluid amylase (DFA) values to stratify patients. The aim of this pilot study was to etermine if intraoperative fluid amylase (IFA) values correlate with DFA1 and POPF. Methods: In patients undergoing PD from February to November 2020, intraoperative samples of intra-abdominal fluid adjacent to the pancreatic anastomosis were taken and sent for fluid amylase measurement prior to abdominal closure. Data regarding patient demographics, postoperative DFA values, complications, and mortality were prospectively collected. Results: Data were obtained for 52 patients with a median alternative Fistula Risk Score (aFRS) of 9.9. Postoperative complications occurred in 20 (38.5%) patients (five Clavien grade ≥ 3). There were eight POPFs and two patients died (pneumonia/sepsis). There was a significant correlation between IFA and DFA1 (R2 = 0.713; p < 0.001) and DFA3 (p < 0.001), and the median IFA was higher in patients with POPF than patients without (1,232.5 vs. 122; p = 0.0003). IFA > 260 U/L predicted POPF with sensitivity, specificity, positive and negative predictive values of 88.0%, 75.0%, 39.0%, and 97.0%, respectively. The incidence of POPF was 43.0% in high-risk (high aFRS/IFA) and 0% in lowrisk patients (low aFRS/IFA). Conclusions: IFA correlated with POPF and may be a useful adjunct to clinical risk scores to stratify patients during PD. Larger, prospective studies are needed to determine whether IFA has clinical utility.

Keywords

Acknowledgement

The Preliminary findings were presented at the 14th Congress of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA); 15-17 September 2021, Bibalo, Spain. HPB 2021;23(Suppl 3):728-729.

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