한국간담췌외과학회지 (Annals of Hepato-Biliary-Pancreatic Surgery)

  • 제27권1호
  • /
  • Pages.107-113
  • /
  • 2023
  • /
  • 2508-5778(pISSN)
  • /
  • 2508-5859(eISSN)
한국간담췌외과학회 (The Korean Association of Hepato-Biliary-Pancreatic Surgery)
권호 표지
DOI QR코드

DOI QR Code

Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: Three case reports and a literature review

  • Min Kyu Sung (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Woohyung Lee (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Sarang Hong (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yejong Park (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Bong Jun Kwak (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ki Byung Song (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jae Hoon Lee (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Dae Wook Hwang (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song Cheol Kim (Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2022.07.22
  • 심사 : 2022.09.07
  • 발행 : 2023.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Mixed adenoneuroendocrine carcinoma is defined as a tumor with a mixture of adenocarcinoma components and neuroendocrine neoplasm components. Each of these two components of mixed adenoneuroendocrine carcinoma accounts for at least 30% of all tumors. Mixed adenoneuroendocrine carcinoma might be located in the ampulla of Vater, a very rare location compared to other organs. Thus, its treatment and prognosis plans have not been established yet. We report three cases of mixed adenoneuroendocrine carcinoma occurring in the ampulla of Vater. Each patient had a different clinical course. In general, difficulty in preoperative diagnosis, risk of early recurrence, and poor disease course were main hallmarks of mixed adenoneuroendocrine carcinoma arising from the ampulla of Vater. However, one patient in this case report survived although she did not receive adjuvant chemotherapy due to her old age. Therefore, it is important to establish a careful treatment strategy for mixed adenoneuroendocrine carcinoma arising from the ampulla of Vater.

키워드

참고문헌

  1. De Mestier L, Cros J, Neuzillet C, Hentic O, Egal A, Muller N, et al. Digestive system mixed neuroendocrine-non-neuroendocrine neoplasms. Neuroendocrinology 2017;105:412-425. 
  2. Vilardell F, Velasco A, Cuevas D, Olsina JJ, Matias-Guiu X. Composite papillary intestinal-type adenocarcinoma/poorly differentiated neuroendocrine carcinoma of the ampulla of Vater. J Clin Pathol 2011;64:174-177. 
  3. Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, et al. Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review. Clin J Gastroenterol 2020;13:37-45. 
  4. Jones MA, Griffith LM, West AB. Adenocarcinoid tumor of the periampullary region: a novel duodenal neoplasm presenting as biliary tract obstruction. Hum Pathol 1989;20:198-200. 
  5. Misonou J, Kanda M, Kitagawa T, Ota T, Muto E, Nenohi M, et al. A case of coexisting malignant carcinoid tumor and adenocarcinoma in the papilla of Vater. Gastroenterol Jpn 1990;25:630-635. 
  6. Burke A, Lee YK. Adenocarcinoid (goblet cell carcinoid) of the duodenum presenting as gastric outlet obstruction. Hum Pathol 1990;21:238-239. 
  7. Shah IA, Schlageter MO, Boehm N. Composite carcinoid-adenocarcinoma of ampulla of Vater. Hum Pathol 1990;21:1188-1190. 
  8. Williams IM, Williams NW, Stock D, Foster ME. Collision tumour of the ampulla of Vater: carcinoid and adenocarcinoma. HPB Surg 1997;10:241-244. 
  9. Alex WR, Auerbach HE, Pezzi CM. Adenocarcinoid tumor of the ampulla of Vater. Am Surg 1998;64:355-359. 
  10. Moncur JT, Lacy BE, Longnecker DS. Mixed acinar-endocrine carcinoma arising in the ampulla of Vater. Hum Pathol 2002;33:449-451. 
  11. Nassar H, Albores-Saavedra J, Klimstra DS. High-grade neuroendocrine carcinoma of the ampulla of vater: a clinicopathologic and immunohistochemical analysis of 14 cases. Am J Surg Pathol 2005;29:588-594. 
  12. Deschamps L, Dokmak S, Guedj N, Ruszniewski P, Sauvanet A, Couvelard A. Mixed endocrine somatostatinoma of the ampulla of Vater associated with a neurofibromatosis type 1: a case report and review of the literature. JOP 2010;11:64-68. 
  13. Zhang L, DeMay RM. Cytological features of mixed adenoneuroendocrine carcinoma of the ampulla: two case reports with review of literature. Diagn Cytopathol 2014;42:1075-1084. 
  14. Huang Z, Xiao WD, Li Y, Huang S, Cai J, Ao J. Mixed adenoneuroendocrine carcinoma of the ampulla: two case reports. World J Gastroenterol 2015;21:2254-2259. 
  15. Ginori A, Lo Bello G, Vassallo L, Tripodi SA. Amphicrine carcinoma of the ampullary region. Tumori 2015;101:e70-e72. 
  16. Li X, Li D, Sun X, Lv G. Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: a case report. J Int Med Res 2020;48:300060520947918. 
  17. Doepker MP, Thompson ZJ, Centeno BA, Kim RD, Wong J, Hodul PJ. Clinicopathologic and survival analysis of resected ampullary adenocarcinoma. J Surg Oncol 2016;114:170-175. 
  18. La Rosa S, Marando A, Sessa F, Capella C. Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract: an update. Cancers (Basel) 2012;4:11-30. 
  19. Acosta AM, Wiley EL. Primary biliary mixed adenoneuroendocrine carcinoma (MANEC): a short review. Arch Pathol Lab Med 2016;140:1157-1162. 
  20. Hatano H, Yoneyama C, Noda T, Tomimaru Y, Hirota M, Takata A, et al. [A case of surgical treatment for mixed adenoneuroendocrine carcinoma of the ampulla of Vater]. Gan To Kagaku Ryoho 2015;42:1755-1757. Japanese.