Annals of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회지)

The Korean Association of Hepato-Biliary-Pancreatic Surgery (한국간담췌외과학회)
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Not a neuroendocrine tumor: A case of hepatocellular carcinoma in ectopic liver tissue in the pancreas

  • Ana Margarida Correia (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Catia Ribeiro (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Flavio Videira (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Davide Gigliano (Department of Anatomical Pathology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Ana Luisa Cunha (Department of Anatomical Pathology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Luis Pedro Afonso (Department of Anatomical Pathology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Mariana Peyroteo (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Rita Canotilho (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Catarina Baia (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Fernanda Sousa (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto)) ;
  • Joaquim Abreu de Sousa (Department of Surgical Oncology, Instituto Portugues de Oncologia do Porto Francisco Gentil (IPO-Porto))
  • Received : 2022.05.09
  • Accepted : 2022.06.29
  • Published : 2023.02.28
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Abstract

Hepatocellular carcinoma (HCC) accounts for most of the hepatic neoplasms and can also occur in ectopic liver tissue. We present a case of a 55-year-old male complaining of weight loss. The imaging studies reported a 2.9 cm nodule in the pancreatic body, with a neuroendocrine tumor diagnosis by cytology. A corpo-caudal pancreatectomy was performed. Pathology showed a well-differentiated HCC developed in ectopic liver tissue with free margins and no lymph node metastases. HCC presenting in ectopic liver tissue is rare. In this case, the preoperative study did not establish the diagnosis, warranting the need for suspicion of this neoplasm.

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References

  1. Forman D, Ferlay J. The global and regional burden of cancer. In: Stewart BW, Wild CP, eds. World cancer report 2014. Lyon: International Agency for Research on Cancer, 2014:16-53. 
  2. Zhuo Y, Chen Q, Chhatwal J. Changing epidemiology of hepatocellular carcinoma and role of surveillance. In: Hoshida Y, ed. Hepatocellular carcinoma: translational precision medicine approaches. Cham: Humana Press, 2019:53-67. 
  3. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Pineros M, et al. Population Fact Sheets - Portugal [Internet]. Lyon: Cancer Today/IARC 2019 [cited 2020 Oct 8]. Available from: https://gco.iarc.fr/today/fact-sheets-populations. 
  4. European Association For The Study Of The Liver, European Organisation For Research And Treatment Of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012;56:908-943. Erratum in: J Hepatol 2012;56:1430. 
  5. Hartke J, Johnson M, Ghabril M. The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol 2017;34:153-159.  https://doi.org/10.1053/j.semdp.2016.12.011
  6. Lee HW, Cho KJ, Park JY. Current status and future direction of immunotherapy in hepatocellular carcinoma: what do the data suggest? Immune Netw 2020;20:e11. 
  7. Lee JY, Kim KH, Kang MS, Kim KH. Ectopic hepatocellular carcinoma arising from the peritoneum in a patient with a history of oropharyngeal cancer: a case report. Case Rep Oncol 2015;8:456-460.  https://doi.org/10.1159/000441020
  8. Cardona D, Grobmyer S, Crawford JM, Liu C. Hepatocellular carcinoma arising from ectopic liver tissue in the pancreas. Virchows Arch 2007;450:225-229.  https://doi.org/10.1007/s00428-006-0353-8
  9. Kanzaki R, Yamada T, Gotoh K, Takahashi H, Ohigashi H, Ishikawa O. Ectopic hepatocellular carcinoma arising in the left triangular ligament of the liver. Case Rep Gastroenterol 2010;4:138-143.  https://doi.org/10.1159/000314042
  10. Adachi Y, Hayashi H, Yusa T, Takematsu T, Matsumura K, Higashi T, et al. Ectopic hepatocellular carcinoma mimicking a retroperitoneal tumor: a case report. World J Gastroenterol 2020;26:2268-2275.  https://doi.org/10.3748/wjg.v26.i18.2268
  11. Braun M, Kuncman W, Teresinski L, Kupnicki P, Jesionek-Kupnicka D, Kordek R. Pure hepatocellular carcinoma originates from an ectopic liver nodule located in the pancreas. Contemp Oncol (Pozn) 2017;21:311-314.  https://doi.org/10.5114/wo.2017.72403
  12. Matsuyama M, Sugiura S, Kakita A, Sato Y, Kuroda M. Hepatocellular carcinoma arising from ectopic liver tissue in the spleen producing insulin-like growth factor II. Pathol Res Pract 2011;207:124-126.  https://doi.org/10.1016/j.prp.2010.09.003
  13. Caygill C, Gatenby P. Ectopic liver and hepatocarcinogenesis. Eur J Gastroenterol Hepatol 2004;16:727-729.  https://doi.org/10.1097/01.meg.0000131037.92864.df
  14. Mani VR, Farooq MS, Soni U, Kalabin A, Rajabalan AS, Ahmed L. Case report of ectopic liver on gallbladder serosa with a brief review of the literature. Case Rep Surg 2016;2016:7273801. 
  15. Li Z, Wu X, Wen T, Li C, Peng W. Multiple ectopic hepatocellular carcinomas in the pancreas: a case report. Medicine (Baltimore) 2017;96:e6747. 
  16. WHO Classification of Tumours Editorial Board. Digestive system tumours: WHO classification of tumours, Volume 1. 5th ed. Lyon: International Agency for Research on Cancer, 2019. 
  17. Zeng SX, Tan SW, Fong CTH, Liang Q, Zhao BL, Liu K, et al. Hepatoid carcinoma of the pancreas: a case report and review of the literature. World J Clin Cases 2020;8:1116-1128.  https://doi.org/10.12998/wjcc.v8.i6.1116
  18. Steen S, Wolin E, Geller SA, Colquhoun S. Primary hepatocellular carcinoma ("hepatoid" carcinoma) of the pancreas: a case report and review of the literature. Clin Case Rep 2013;1:66-71.  https://doi.org/10.1002/ccr3.26
  19. Kubota K, Kita J, Rokkaku K, Iwasaki Y, Sawada T, Imura J, et al. Ectopic hepatocellular carcinoma arising from pancreas: a case report and review of the literature. World J Gastroenterol 2007;13:4270-4273.  https://doi.org/10.3748/wjg.v13.i31.4270
  20. Kelly PJ, Spence R, Dasari BV, Burt AD, Taylor M, Loughrey MB. Primary hepatocellular carcinoma of the pancreas: a case report and review of the heterogeneous group of pancreatic hepatoid carcinomas. Histopathology 2012;60:1012-1015. https://doi.org/10.1111/j.1365-2559.2011.04129.x