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Outcomes of endoscopic retrograde cholangiopancreatography-guided gallbladder drainage compared to percutaneous cholecystostomy in acute cholecystitis

  • Hassam Ali (Department of Gastroenterology, East Carolina University/Vidant Medical Center) ;
  • Sheena Shamoon (Department of Internal Medicine, Rawalpindi Medical University) ;
  • Nicole Leigh Bolick (Department of Dermatology, University of New Mexico) ;
  • Swethaa Manickam (Department of Gastroenterology, East Carolina University/Vidant Medical Center) ;
  • Usama Sattar (Department of Internal Medicine, Quaid-e-Azam Medical College) ;
  • Shiva Poola (Department of Gastroenterology, East Carolina University/Vidant Medical Center) ;
  • Prashant Mudireddy (Department of Gastroenterology, East Carolina University/Vidant Medical Center)
  • 투고 : 2022.08.17
  • 심사 : 2022.09.20
  • 발행 : 2023.02.28

초록

Backgrounds/Aims: Endoscopic retrograde cholangiopancreatography-guided gallbladder drainage (ERGD) is an alternative to percutaneous cholecystostomy (PTC) for hospitalized acute cholecystitis (AC) patients. Methods: We retrospectively analyzed propensity score matched (PSM) AC hospitalizations using the National Inpatient Sample database between 2016 and 2019 to compare the outcomes of ERGD and PTC. Results: After PSM, there were 3,360 AC hospitalizations, with 48.8% undergoing PTC and 51.2% undergoing ERGD. There was no difference in median length of stay between the PTC and ERGD cohorts (p = 0.110). There was a higher median hospitalization cost in the ERGD cohort, $62,562 (interquartile range [IQR] $40,707-97,978) compared to PTC, $40,413 (IQR $25,244-65,608; p < 0.001). The 30-day inpatient mortality was significantly lower in hospitalizations with ERGD compared to PTC (adjusted hazard ratio 0.16, 95% confidence interval [CI]: 0.1-0.41; p < 0.001). There was no difference in association with blood transfusions, acute renal failure, ileus, small bowel obstruction, and open cholecystectomy conversion (p > 0.05) between hospitalizations with ERGD and PTC. There was lower association of acute hypoxic respiratory failure (adjusted ratio [AOR] 0.46, 95% CI: 0.29-0.72; p = 0.001), hypovolemia (AOR 0.66, 95% CI: 0.49-0.82; p = 0.009) and higher association of lower gastrointestinal bleed (AOR 1.94, 95% CI: 1.48-2.54; p < 0.001) with ERGD compared to PTC. Conclusions: ERGD is a safer alternative to PTC in patients with AC. The risk complications are lower in ERGD compared to PTC but no difference exists based on mortality or conversion to open cholecystectomy.

키워드

참고문헌

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