Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Benefits of Soybean in the Era of Precision Medicine: A Review of Clinical Evidence

  • Jung Hyun Kang (Department of Food and Nutrition, Gyeongsang National University) ;
  • Zigang Dong (Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University) ;
  • Seung Ho Shin (Department of Food and Nutrition, Gyeongsang National University)
  • Received : 2023.08.11
  • Accepted : 2023.08.21
  • Published : 2023.12.28
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Abstract

Soybean (Glycine max) is an important ingredient of cuisines worldwide. While there is a wealth of evidence that soybean could be a good source of macronutrients and phytochemicals with healthpromoting effects, concerns regarding adverse effects have been raised. In this work, we reviewed the current clinical evidence focusing on the benefits and risks of soybean ingredients. In breast, prostate, colorectal, ovarian, and lung cancer, epidemiological studies showed an inverse association between soybean food intake and cancer risks. Soybean intake was inversely correlated with risks of type 2 diabetes mellitus (T2DM), and soy isoflavones ameliorated osteoporosis and hot flashes. Notably, soybean was one of the dietary protein sources that may reduce the risk of breast cancer and T2DM. However, soybean had adverse effects on certain types of drug treatment and caused allergies. In sum, this work provides useful considerations for planning clinical soybean research and selecting dietary protein sources for human health.

Keywords

Acknowledgement

This work was supported by the National Natural Science Foundation of China (No. 82002620, No. 81972839, NO. 8207112153, Z.D.), the Science and Technology Project of Henan Province (No. 212102310698, NO. 222102310102, Z.D.) and the National Research Foundation of Korea grant funded by the Korean government (MSIP) (NRF-2021R1C1C1013592).

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