Journal of Microbiology and Biotechnology

  • 제33권11호
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  • Pages.1467-1474
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  • 2023
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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The In Vivo and In Vitro Effects of Terminalia bellirica (Gaertn.) Roxb. Fruit Extract on Testosterone-Induced Hair Loss

  • Min Jeong Woo (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Ha Yeong Kang (School of Food Science and Biotechnology, Kyungpook National University) ;
  • So Jeong Paik (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Hee Jung Choi (School of Food Science and Biotechnology, Kyungpook National University) ;
  • Salah Uddin (Ethnobotanical Database of Bangladesh (EDB)) ;
  • Sangwoo Lee (International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology) ;
  • Soo-Yong Kim (International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology) ;
  • Sangho Choi (International Biological Material Research Center, Korea Research Institute of Bioscience & Biotechnology) ;
  • Sung Keun Jung (School of Food Science and Biotechnology, Kyungpook National University)
  • 투고 : 2023.06.05
  • 심사 : 2023.07.12
  • 발행 : 2023.11.28
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초록

Due to the continuous increase in patients with androgenetic alopecia (AGA) and psychological disorders such as depression and anxiety, the demand for hair loss treatment and effective hair growth materials has increased. Terminalia bellirica (Gaertn.) Roxb. (TBE) reportedly exerts anti-inflammatory, hepatoprotective, and antidiabetic effects, among others, but its effects on testosterone (TS)-inhibited hair growth remains unclear. In this study, we evaluated the effects of TBE on TS-induced hair growth regression in human follicle dermal papilla cells (HFDPCs) and C57BL/6 mice. Oral administration of TBE increased TS-induced hair growth retardation. Interestingly, effects were greater when compared with finasteride, a commercial hair loss treatment product. Histological analyses revealed that oral TBE administration increased hair follicles in the dorsal skin of C57BL/6 mice. Additionally, western blotting and immunofluorescence showed that oral TBE administration recovered the TS-induced inhibition of cyclin D1, proliferating cell nuclear antigen (PCNA), and Ki67 expression in vivo. Using in vitro proliferation assays, TBE promoted HFDPC growth, which was suppressed by TS treatment. Thus, TBE may be a promising nutraceutical for hair health as it promoted hair growth in AGA-like in vitro and in vivo models.

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과제정보

This study was supported by the Korea Research Institute of Bioscience & Biotechnology Initiative Program of the Republic of Korea.

참고문헌

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