Journal of Dental Anesthesia and Pain Medicine

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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Effect of propofol on salivary secretion from the submandibular, sublingual, and labial glands during intravenous sedation

  • Keisuke Masuda (Department of Oral Function and Molecular Biology, Ohu University School of Dentistry) ;
  • Akira Furuyama (Department of Oral Function and Molecular Biology, Ohu University School of Dentistry) ;
  • Kenji Ohsuga (Department of Oral Function and Molecular Biology, Ohu University School of Dentistry) ;
  • Shota Abe (Department of Dental Anesthesiology, Ohu University School of Dentistry) ;
  • Hiroyoshi Kawaai (Department of Oral Function and Molecular Biology, Ohu University School of Dentistry)
  • Received : 2023.02.08
  • Accepted : 2023.04.25
  • Published : 2023.06.01
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Abstract

Background: Recent animal studies have suggested the role of GABA type A (GABA-A) receptors in salivation, showing that GABA-A receptor agonists inhibit salivary secretion. This study aimed to evaluate the effects of propofol (a GABA-A agonist) on salivary secretions from the submandibular, sublingual, and labial glands during intravenous sedation in healthy volunteers. Methods: Twenty healthy male volunteers participated in the study. They received a loading dose of propofol 6 mg/kg/h for 10 min, followed by 3 mg/kg/h for 15 min. Salivary flow rates in the submandibular, sublingual, and labial glands were measured before, during, and after propofol infusion, and amylase activity was measured in the saliva from the submandibular and sublingual glands. Results: We found that the salivary flow rates in the submandibular, sublingual, and labial glands significantly decreased during intravenous sedation with propofol (P < 0.01). Similarly, amylase activity in the saliva from the submandibular and sublingual glands was significantly decreased (P < 0.01). Conclusion: It can be concluded that intravenous sedation with propofol decreases salivary secretion in the submandibular, sublingual, and labial glands via the GABA-A receptor. These results may be useful for dental treatment when desalivation is necessary.

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References

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