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Exposure Assessment of Biogenic Amines as a Chemical Hazard in Commercial Anchovy Fish Sauce from South Korea

멸치액젓의 화학적 위해요소로서의 바이오제닉 아민 노출 평가

  • Eungyeong Kim (Food Standard Research Center, Korea Food Research Institute) ;
  • Heeyoung Lee (Food Standard Research Center, Korea Food Research Institute) ;
  • Sunhyun Park (Food Standard Research Center, Korea Food Research Institute)
  • 김은경 (한국식품연구원 식품표준연구센터) ;
  • 이희영 (한국식품연구원 식품표준연구센터) ;
  • 박선현 (한국식품연구원 식품표준연구센터)
  • Received : 2023.02.08
  • Accepted : 2023.06.26
  • Published : 2023.06.30

Abstract

This study was conducted to evaluate the chemical hazards of 74 kinds of commercial anchovy fish sauce in Korea by measuring their biogenic amine content. The biogenic amines detected in commercial anchovy fish sauce were tryptamine, putrescine, cadaverine, tyramine, spermidine, spermine, and histamine. Among them, histamine content was the highest with an average of 1,439.62±812.62 mg/kg. Excessive intake of histamine could result in chemical food poisoning characterized by high blood pressure, headache, and diarrhea. Accordingly, by simulating histamine exposure (repetition=10,000 times) based on the daily intake of 0.969 g of domestic anchovy fish sauce, we found that the estimated average histamine exposure was 24.49±55.48 ㎍/kg bw/day and that the margins of exposure (MOE) value were 139.18 at 1% and 66,141.07 at 95% of 10,000 simulations (9,500 times). As such, it was confirmed that 9,500 out of 10,000 simulations of MOE analysis significantly exceeded MOE 10. Therefore, the risk of exposure to histamine from ingestion of commercial anchovy fish sauce is approximately very low.

Keywords

Acknowledgement

이 논문은 2022년, 2023년 과학기술정보통신부 재원으로 한국식품연구원의 지원을 받아 연구되었으며(E0211400-02, E0211400-03) 이에 감사드립니다.

References

  1. Cho TY, Han GH, Bahn KN, Son YW, Jang MR, Lee CH, Kim SH, Kim DB, Kim SB. 2006. Evaluation of biogenic amines in Korean commercial fermented foods. Korean J Food Sci Technol. 38(6):730-737.
  2. Cho YJ, Im YS, Park HY, Choi YJ. 2000. Quality characteristics of Southeast Asian salt-fermented fish sauces. Korean J Fish Aquat Sci. 33(2):98-102.
  3. Cho YJ, Jung MH, Kim BK, Jung WY, Gye HJ, Jung HJ. 2015. Effect of raw material freshness on quality and safety of anchovy fish sauce. J Kor Soc Fish Mar Edu. 27(4):1194-1201.
  4. Chung SP. 2019. Scombroid fish poisoning and histamine food poisoning. J Korean Soc Clin Toxicol. 17(1):1-6. https://doi.org/10.22537/jksct.17.1.1
  5. Codex Alimentarius. 2018. Standard for fish sauce. CODEX STAN 302-2011. Food and Agriculture Organization of 353 the United Nations and World Health Organization, Rome, Italy.
  6. European Food Safety Authority(EFSA). 2005. Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA Journal. 3(10):282.
  7. Feng C, Teuber S, Gershwin ME. 2016. Histamine (scombroid) fish poisoning: a comprehensive review. Clinic Rev Allerg Immunol. 50:64-69. https://doi.org/10.1007/s12016-015-8467-x
  8. Hungerford JM. 2010. Scombroid poisoning: a review. Toxicon. 56(2):231-243. https://doi.org/10.1016/j.toxicon.2010.02.006
  9. Joung BC, Min JG. 2018. Changes in postfermentation quality during the distribution process of anchovy (Engraulis japonicus) fish sauce. J Food Prot. 81(6):969-976. https://doi.org/10.4315/0362-028X.JFP-17-348
  10. Karovicova J, Kohajdova Z. 2005. Biogenic amines in food. Chem Pap. 59(1):70-79. https://doi.org/10.1002/chin.200534338
  11. Kim BK, Kim YH, Lee HH, Cho YJ, Kim DS, Oh SM, Shim KB. 2011. Comparison of the chemical compositions and biogenic amine contents of salt-fermented fish sauces produced in Korea to evaluate the quality characteristics. J Kor Soc Fish Mar Edu. 23(4):607-614.
  12. Kim JH, Ryu GH, Ahn HJ, Lee KH, Lee HJ, Byun MW. 2000. Quality evaluation of commercial salted and fermented anchovy sauce. J Korean Soc Food Sci Nutr. 29(5):837-842.
  13. Kim SH, Barros-Velazquez J, Ben-Gigirey B, Eun JB, Jun SH, Wei CI. 2003. Identification of the main bacteria contributing to histamine formation in seafood to ensure product safety. Food Sci Biotechnol. 12:451-460.
  14. Kim SH, Eun JB, Chen TY, Wei CI, Clemens RA, An H. 2004. Evaluation of histamine and other biogenic amines and bacterial isolation in canned anchovies recalled by the USFDA. J Food Sci. 69(6):M157-M162. https://doi.org/10.1111/j.1365-2621.2004.tb11003.x
  15. Kim SM. 2020. The present condition and development prospect of the fermented fishery products. Food Sci Ind. 53(2):200-214.
  16. Kim YM. 2008. Present status and prospect of fermented seafood industry in Korea. Food Sci Ind. 41(4):16-33.
  17. Kim YS, Kim BH, Kim K, Kim DH, Yun HJ, Kwak SH, Kang KJ, Cho WH, Moh A, Choi OK, Yoon MH. 2020. Safety assessment of biogenic amines in school-meal fishery products. J Food Saf. 35(2):125-135.
  18. Ko YA, Kim SH, Song HS. 2017. Effect of salt concentration and fermentation temperature on changes in quality index of salted and fermented anchovy during fermentation. J Food Saf. 32(1): 27-34. https://doi.org/10.13103/JFHS.2017.32.1.27
  19. Kwon SS, Kim SJ, Shin HY, Shin IS. 2019. Effect of microcapsule entrapping isothiocyanates (ITCs) extracted from horseradish Armoracia rusticana root on shelf-life extension of Myeongran Jeotgal, a Korean salted and fermented seafood. Korean J Fish Aquat Sci. 52(4):349-357.
  20. Lee JM, Lee DC, Kim SM. 2013. The effects of Koji and histidine on the formation of histamine in anchovy sauce and the growth inhibition of histamine degrading bacteria with preservatives. Am J Food Technol. 1:25-36. https://doi.org/10.7726/ajafst.2013.1003
  21. Lee MH, Jeong IH, Jeong ST, Chang YH. 2021. Effect of Nuruk protease activity on the quality of anchovy sauce. Korean J Food Sci Technol. 53(3):356-363.
  22. Li B, Lu S. 2020. The importance of amine-degrading enzymes on the biogenic amine degradation in fermented foods: A review. Process Biochem. 99:331-339. https://doi.org/10.1016/j.procbio.2020.09.012
  23. Lim ES. 2020. Evaluation of microbial contamination levels and biogenic amines content in over-ripened kimchi. Korean J Food Preserv. 27(5):635-650. https://doi.org/10.11002/kjfp.2020.27.5.635
  24. Lim YS, You BJ, Choi YJ, Cho YJ. 2002. Difference of components changes in salt-fermented anchovy, Engraulis japonicus sauce by tank size during fermentation. Korean J Fish Aquat Sci. 35(3): 302-307.
  25. Lin CS, Liu FL, Lee YC, Hwang CC, Tsai YH. 2012. Histamine contents of salted seafood products in Taiwan and isolation of halotolerant histamine-forming bacteria. Food Chem. 131(2):574-579. https://doi.org/10.1016/j.foodchem.2011.09.027
  26. Park JH, Kim SM. 2003. Biofunctionality of peptides purified from naturally fermented anchovy sauce. J Korean Soc Food Sci Nutr. 32(7):1120-1125. https://doi.org/10.3746/jkfn.2003.32.7.1120
  27. Park S, Sung J, Choi HY, Jeong J, Jeong HG, Kim JC, Jang M. 2023. Changes in the physicochemical properties and metabolites of Myeolchi-jeot (salted-fermented anchovy) based on fermentation time. LWT, 114456.
  28. Stratton JE, Hutkins RW, Taylor SL. 1991. Biogenic amines in cheese and other fermented foods: a review. J Food Prot. 54(6): 460-470. https://doi.org/10.4315/0362-028X-54.6.460
  29. Suzzi G, Torriani S. 2015. Biogenic amines in foods. Front Microbiol. 6:472.
  30. Um IS, Seo JK, Kim HD, Park KS. 2018. The quality of commercial salted and fermented anchovy Engraulis japonicas sauces produced in Korea. Korean J Fish Aquat Sci. 51(6):667-672.
  31. Yoon H, Park JH, Choi A, Hwang HJ, Mah JH. 2015. Validation of an HPLC analytical method for determination of bio-genic amines in agricultural products and monitoring of biogenic amines in Korean fermented agricultural products. Toxicol Res. 31:299-305. https://doi.org/10.5487/TR.2015.31.3.299
  32. Yoon HJ, Ham IT, Kim JS, Choi JD. 2017. Physicochemical and microbiological characteristics of raw anchovies and boiled-dried anchovies on the market. J Kor Soc Fish Mar Edu. 29(6):1945-1955.
  33. Korea Standard, 2021, Fermented anchovy sauce, [cited 2023 Feb 6], Available from: https://e-ks.kr/streamdocs/view/sd;streamdocsId=72059268201581582
  34. Ministry of Food and Drug Safety, 2019, Common guidelines for risk assessment of human applied products, [cited 2023 Feb 6], Available from: https://mfds.go.kr/brd/m_1059/view.do?seq=14364&srchFr=&srchTo=&srchWord=&srchTp=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_nm=&page=10
  35. Ministry of Food and Drug Safety, 2023, Response to Korean Food Standards Codex, [cited 2023 Feb 6], Available from: https://various.foodsafetykorea.go.kr/fsd/#/ext/Document/FC
  36. The Korea Disease Control and Prevention Agency. 2021.The Korea National Health and Nutrition Examination Survey. [cited 2023 Feb 6], Available from: https://knhanes.kdca.go.kr/knhanes/main.do