Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

Prevalence of Senecavirus A in pigs from 2014 to 2020: a global systematic review and meta-analysis

  • Xuhua Ran (School of Animal Science and Technology, Hainan University) ;
  • Zhenru Hu (School of Animal Science and Technology, Hainan University) ;
  • Jun Wang (College of Animal Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Zhiyuan Yang (College of Animal Science and Technology, Heilongjiang Bayi Agricultural University) ;
  • Zhongle Li (College of Animal Science and Technology, Jilin Agricultural University) ;
  • Xiaobo Wen (School of Animal Science and Technology, Hainan University)
  • Received : 2022.11.30
  • Accepted : 2023.05.10
  • Published : 2023.05.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Senecavirus A (SVA), a member of the family Picornaviridae, is newly discovered, which causes vesicular lesions, lameness in swine, and even death in neonatal piglets. SVA has rapidly spread worldwide in recent years, especially in Asia. Objectives: We conducted a global meta-analysis and systematic review to determine the status of SVA infection in pigs. Methods: Through PubMed, VIP Chinese Journals Database, China National Knowledge Infrastructure, and Wanfang Data search data from 2014 to July 26, 2020, a total of 34 articles were included in this analysis based on our inclusion criteria. We estimated the pooled prevalence of SVA in pigs by the random effects model. A risk of bias assessment of the studies and subgroup analysis to explain heterogeneity was undertaken. Results: We estimated the SVA prevalence to be 15.90% (1,564/9,839; 95% confidence interval [CI], 44.75-65.89) globally. The prevalence decreased to 11.06% (945/8,542; 95% CI, 28.25-50.64) after 2016. The highest SVA prevalence with the VP1-based RT-PCR and immunohistochemistry assay was 58.52% (594/1,015; 95% CI, 59.90-83.96) and 85.54% (71/83; 95% CI, 76.68-100.00), respectively. Besides, the SVA prevalence in piglet herds was the highest at 71.69% (119/166; 95% CI, 68.61-98.43) (p < 0.05). Moreover, our analysis confirmed that the subgroups, including country, sampling year, sampling position, detected gene, detection method, season, age, and climate, could be the heterogeneous factors associated with SVA prevalence. Conclusions: The results indicated that SVA widely exists in various countries currently. Therefore, more prevention and control policies should be proposed to enhance the management of pig farms and improve breeding conditions and the environment to reduce the spread of SVA.

Keywords

Acknowledgement

This work was supported by the Natural Science Foundation for the Excellent Scholars of Hainan Province of China (No. 320RC461), the earmarked fund for the Agriculture Research System in Hainan Province (No. HNARS2022-2-G4) and the Intramural Project of Hainan University (No. KYQD(ZR)20036).

References

  1. Singh K, Corner S, Clark SG, Scherba G, Fredrickson RL. Seneca valley virus and vesicular lesions in a pig with idiopathic vesicular disease. J Vet Sci Technol. 2012;3(6):1000123.
  2. Hales LM, Knowles NJ, Reddy PS, Xu L, Hay C, Hallenbeck PL. Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus. J Gen Virol. 2008;89(Pt 5):1265-1275. https://doi.org/10.1099/vir.0.83570-0
  3. Zhu Z, Yang F, Chen P, Liu H, Cao W, Zhang K, et al. Emergence of novel Seneca Valley virus strains in China, 2017. Transbound Emerg Dis. 2017;64(4):1024-1029. https://doi.org/10.1111/tbed.12662
  4. Montiel N, Buckley A, Guo B, Kulshreshtha V, VanGeelen A, Hoang H, et al. Vesicular disease in 9-week-old pigs experimentally infected with Senecavirus A. Emerg Infect Dis. 2016;22(7):1246-1248. https://doi.org/10.3201/eid2207.151863
  5. Leme RA, Zotti E, Alcantara BK, Oliveira MV, Freitas LA, Alfieri AF, et al. Senecavirus A: an emerging vesicular infection in Brazilian pig herds. Transbound Emerg Dis. 2015;62(6):603-611. https://doi.org/10.1111/tbed.12430
  6. Leme RA, Oliveira TE, Alfieri AF, Headley SA, Alfieri AA. Pathological, immunohistochemical and molecular findings associated with Senecavirus A-induced lesions in neonatal piglets. J Comp Pathol. 2016;155(2-3):145-155. https://doi.org/10.1016/j.jcpa.2016.06.011
  7. Sharma B, Fernandes MH, de Lima M, Joshi LR, Lawson S, Diel DG. A novel live attenuated vaccine candidate protects against heterologous Senecavirus A challenge. Front Immunol. 2019;10(1):2660.
  8. Canning P, Canon A, Bates JL, Gerardy K, Linhares DC, Pineyro PE, et al. Neonatal mortality, vesicular lesions and lameness associated with Senecavirus A in a U.S. sow farm. Transbound Emerg Dis. 2016;63(4):373-378. https://doi.org/10.1111/tbed.12516
  9. Pasma T, Davidson S, Shaw SL. Idiopathic vesicular disease in swine in Manitoba. Can Vet J. 2008;49(1):84-85.
  10. Saeng-Chuto K, Rodtian P, Temeeyasen G, Wegner M, Nilubol D. The first detection of Senecavirus A in pigs in Thailand, 2016. Transbound Emerg Dis. 2018;65(1):285-288. https://doi.org/10.1111/tbed.12654
  11. Arzt J, Bertram MR, Vu LT, Pauszek SJ, Hartwig EJ, Smoliga GR, et al. First detection and genome sequence of Senecavirus A in Vietnam. Microbiol Resour Announc. 2019;8(3):e01247-18.
  12. Sun D, Vannucci F, Knutson TP, Corzo C, Marthaler DG. Emergence and whole-genome sequence of Senecavirus A in Colombia. Transbound Emerg Dis. 2017;64(5):1346-1349. https://doi.org/10.1111/tbed.12669
  13. Liu J, Ren X, Li Z, Xu G, Lu R, Zhang K, et al. Genetic and phylogenetic analysis of reemerged novel Seneca Valley virus strains in Guangdong province, 2017. Transbound Emerg Dis. 2018;65(3):614-617. https://doi.org/10.1111/tbed.12839
  14. Zhang X, Xiao J, Ba L, Wang F, Gao D, Zhang J, et al. Identification and genomic characterization of the emerging Senecavirus A in southeast China, 2017. Transbound Emerg Dis. 2018;65(2):297-302. https://doi.org/10.1111/tbed.12750
  15. Pengchun Z. Analysis of pig breeding mode and development trend in China. China Feed. 2018;616(20):90-93. 
  16. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
  17. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924-926. https://doi.org/10.1136/bmj.39489.470347.AD
  18. Wang ZD, Wang SC, Liu HH, Ma HY, Li ZY, Wei F, et al. Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis. Lancet HIV. 2017;4(4):e177-e188. https://doi.org/10.1016/S2352-3018(17)30005-X
  19. Ni HB, Gong QL, Zhao Q, Li XY, Zhang XX. Prevalence of Haemophilus parasuis "Glaesserella parasuis" in pigs in China: a systematic review and meta-analysis. Prev Vet Med. 2020;182:105083.
  20. Wei XY, Gong QL, Zeng A, Wang W, Wang Q, Zhang XX. Seroprevalence and risk factors of Toxoplasma gondii infection in goats in China from 2010 to 2020: a systematic review and meta-analysis. Prev Vet Med. 2021;186:105230.
  21. R Core Team. A language and environment for statistical computing. 4th ed. Vienna: R Foundation for Statistical Computing; 2019. 
  22. Li X, Ni HB, Ren WX, Jiang J, Gong QL, Zhang XX. Seroprevalence of Toxoplasma gondii in horses: a global systematic review and meta-analysis. Acta Trop. 2020;201:105222.
  23. Assefa A, Bihon A. Bovine cysticercosis in Ethiopia: a systematic review and meta-analysis of prevalence from abattoir-based surveys. Prev Vet Med. 2019;169:104707.
  24. Gong QL, Wang Q, Yang XY, Li DL, Zhao B, Ge GY, et al. Seroprevalence and risk factors of the bluetongue virus in cattle in China from 1988 to 2019: a comprehensive literature review and metaanalysis. Front Vet Sci. 2021;7:550381.
  25. Ding H, Gao YM, Deng Y, Lamberton PH, Lu DB. A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China. Parasit Vectors. 2017;10(1):27. 
  26. Wang W, Gong QL, Zeng A, Li MH, Zhao Q, Ni HB. Prevalence of cryptosporidium in pigs in China: a systematic review and meta-analysis. Transbound Emerg Dis. 2021;68(3):1400-1413. https://doi.org/10.1111/tbed.13806
  27. Lin X, Xiaohui W, Dianhong L, Shaolun Z, Wei H, Qi Z, et al. Isolation, identification and genetic evolution analysis of new epidemic strains of Senecavirus A in Guangdong province. Guangdong Agric Sci. 2019;46(06):125-132. 
  28. Bai ZH, Jin SQ, Wu Y, zu Ermgassen E, Oenema O, Chadwick D, et al. China's pig relocation in balance. Nat Sustain. 2019;2(10):888.
  29. Wang MM. Isolation and identification of Senecavirus A and construction of its infectious clone [master thesis]. Yangzhou: Yangzhou University; 2020. 
  30. Dall Agnol AM, Miyabe FM, Leme RA, Oliveira TE, Headley SA, Alfieri AA, et al. Quantitative analysis of Senecavirus A in tissue samples from naturally infected newborn piglets. Arch Virol. 2018;163(2):527-531. https://doi.org/10.1007/s00705-017-3630-8
  31. Feronato C, Leme RA, Diniz JA, Agnol AM, Alfieri AF, Alfieri AA. Development and evaluation of a nested-PCR assay for Senecavirus A diagnosis. Trop Anim Health Prod. 2018;50(2):337-344. https://doi.org/10.1007/s11250-017-1436-z
  32. Armson B, Walsh C, Morant N, Fowler VL, Knowles NJ, Clark D. The development of two field-ready reverse transcription loop-mediated isothermal amplification assays for the rapid detection of Seneca Valley virus 1. Transbound Emerg Dis. 2019;66(1):497-504. https://doi.org/10.1111/tbed.13051
  33. Rigotto C, Sincero TC, Simoes CM, Barardi CR. Detection of adenoviruses in shellfish by means of conventional-PCR, nested-PCR, and integrated cell culture PCR (ICC/PCR). Water Res. 2005;39(2-3):297-304. https://doi.org/10.1016/j.watres.2004.10.005
  34. Zhang Z, Zhang Y, Lin X, Chen Z, Wu S. Development of a novel reverse transcription droplet digital PCR assay for the sensitive detection of Senecavirus A. Transbound Emerg Dis. 2019;66(1):517-525. https://doi.org/10.1111/tbed.13056
  35. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, et al. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One. 2013;8(4):e55943.
  36. Resende TP, Marthaler DG, Vannucci FA. A novel RNA-based in situ hybridization to detect Seneca Valley virus in neonatal piglets and sows affected with vesicular disease. PLoS One. 2017;12(4):e0173190.
  37. Hause BM, Myers O, Duff J, Hesse RA. Senecavirus A in pigs, United States, 2015. Emerg Infect Dis. 2016;22(7):1323-1325. https://doi.org/10.3201/eid2207.151591
  38. Mancinelli AC, Dal Bosco A, Mattioli S, Ranucci D, Castellini C. Mobile poultry processing unit as a resource for small poultry farms: planning and economic efficiency, animal welfare, meat quality and sanitary implications. Animals (Basel). 2018;8(12):229.
  39. Tousignant SJ, Bruner L, Schwartz J, Vannucci F, Rossow S, Marthaler DG. Longitudinal study of Senecavirus a shedding in sows and piglets on a single United States farm during an outbreak of vesicular disease. BMC Vet Res. 2017;13(1):277.