Journal of Veterinary Science

  • 제24권3호
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  • Pages.43.1-43.8
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  • 2023
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  • 1229-845X(pISSN)
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  • 1976-555X(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Effects on hematology and blood biochemistry profile of intramuscular meloxicam injection in Brahminy kite and Barn owl

  • Ratiwan Sitdhibutr (Kasetsart University Raptor Rehabilitation Unit, Kamphaengsaen Campus) ;
  • Raveewan Ploypan (Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkhen Campus) ;
  • Sirawit Subaneg (Laboratory of Raptor Research and Conservation Medicine, Faculty of Veterinary Medicine, Kasetsart University) ;
  • Chaiyan Kasorndorkbua (Department of Pathology, Faculty of Veterinary Medicine, Kasetsart University, Bangkhen Campus)
  • 투고 : 2023.01.20
  • 심사 : 2023.04.19
  • 발행 : 2023.05.31
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초록

Background: Meloxicam is used widely for exotic animal analgesia, but its toxicity in common raptor species in Thailand is unclear. Objectives: This study evaluated the single-dose effect of intramuscular meloxicam in common raptor species in Thailand for short-term and long-term periods. Methods: Twenty-two raptors were administered a single 1 mg/kg dose of meloxicam individually via intramuscular injection. The following were evaluated: clinical appearance, body weight, body condition score, body temperature, fecal appearance, complete blood cell count, and biochemistry panel before (day 0) and after the injection (1, 7, and 30 days). The collected samples were categorized into three groups: Brahminy kite (Haliastur indus) (n = 10), adult Barn owl (Tyto javanica) (n = 4), and juvenile Barn owl (n = 8). Results: None of the raptors in the study groups showed any abnormalities. The hematological profiles were significantly different in the short-term period (day 1 and day 7). The creatinine, aspartate aminotransferase, and creatinine kinase increased in several groups. On the other hand, the packed cell volume decreased in the Brahminy kite and juvenile Barn owl groups. According to the findings, an intramuscular injection of 1 mg/kg meloxicam affected the blood biochemistry panel of the muscle, but the affected raptors recovered within one week. Conclusions: An intramuscular injection of meloxicam at a single 1 mg/kg dose in Brahminy kites and Barn owls was not associated with the morbidity, hepatotoxicity, gastrointestinal toxicity, and nephrotoxicity in the short- and long-term periods.

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과제정보

The authors wish to thank all staff in the laboratory unit of Kasetsart University Veterinary Teaching Hospital, Kamphaengsaen, Nakhonpathom, and veterinary student volunteers at Kasetsart University Raptor Rehabilitation Unit (KURU) for assistance. The raptor rehabilitation for release is the cooperation with Thailand's Department of National Parks, Wildlife, and Plant Conservation. This study was supported financially by the Raptor Research Fund for Conservation, and the Faculty of Veterinary Medicine, Kasetsart University.

참고문헌

  1. Oaks JL, Meteyer CU. Non-steroidal anti-inflammatory drugs in raptors. In: Miller RE, Fowler ME, editors. Fowler's Zoo and Wild Animal Medicine, Vol. 7. Philadelphia: Elsevier Saunders; 2012, 349-355. 
  2. Malik A, Valentine A. Pain in birds: a review for veterinary nurses. Vet Nurs. 2018;33(1):11-25. https://doi.org/10.1080/17415349.2017.1395304
  3. Samour J. Analgesia. In: Avian Medicine. 3rd ed. Missouri: Elsevier Saunders; 2016, 192-199. 
  4. Hawkins MG, Paul-Murphy J. Avian analgesia. Vet Clin North Am Exot Anim Pract. 2011;14(1):61-80. https://doi.org/10.1016/j.cvex.2010.09.011
  5. Cuthbert R, Parry-Jones J, Green RE, Pain DJ. NSAIDs and scavenging birds: potential impacts beyond Asia's critically endangered vultures. Biol Lett. 2007;3(1):90-93. https://doi.org/10.1098/rsbl.2006.0554
  6. Plumb DC. Meloxicam. Plumb's Veterinary Drug Handbook. 7th ed. Iowa: Blackwell; 2011, 2258-2266. 
  7. Summa NM, Guzman DS, Larrat S, Troncy E, Bird DM, Lair S, et al. Evaluation of high dosages of oral meloxicam in American kestrels (Falco sparverius). J Avian Med Surg. 2017;31(2):108-116. https://doi.org/10.1647/2015-150
  8. Szabo Z, Klein A, Jakab C. Hematologic and plasma biochemistry reference intervals of healthy adult barn owls (Tyto alba). Avian Dis. 2014;58(2):228-231. https://doi.org/10.1637/10715-111013-Reg.1
  9. Salakij C, Kasorndorkbua C, Pornpanom P, Salakij J, Jakthong P. Quantitative and qualitative characteristics of blood cells in black-shouldered, Brahminy, and black kites. Vet Clin Pathol. 2019;48(1):19-30. https://doi.org/10.1111/vcp.12691
  10. Lacasse C, Gamble KC, Boothe DM. Pharmacokinetics of a single dose of intravenous and oral meloxicam in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus). J Avian Med Surg. 2013;27(3):204-210. https://doi.org/10.1647/2012-044
  11. Joseph V. Raptor medicine: an approach to wild, falconry, and educational birds of prey. Vet Clin North Am Exot Anim Pract. 2006;9(2):321-345. https://doi.org/10.1016/j.cvex.2006.03.007
  12. Salakij C, Pornpanom P, Lertwatcharasarakul P, Kasorndorkbua C, Salakij J. Haemoproteus in barn and collared scops owls from Thailand. J Vet Sci. 2018;19(2):280-289. https://doi.org/10.4142/jvs.2018.19.2.280
  13. Samour J. Diagnostic value of hematology. In: Harrison GJ, Lightfoot TL, editors. Clinical Avian Medicine, Vol. 1. Palm Beach: Spix Publishing; 2006, 587-609. 
  14. Schafer AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol. 1995;35(3):209-219. https://doi.org/10.1002/j.1552-4604.1995.tb04050.x
  15. Cotter SM. Platelet disorders in animals [Internet]. Rahway: Merck & Co., Inc.; https://www.merckvetmanual.com/circulatory-system/hemostatic-disorders/platelet-disorders-in-animals. Updated 2019. Accessed 2021 Nov 10. 
  16. Hiran S, Mazumdar D, Sarma PS. Acute thrombocytopenic purpura due to meloxicam. J Assoc Physicians India. 2003;51:531-532.
  17. Ranieri MM, Bradley EF, Simon AB. Meloxicam-induced thrombocytopenia. Pharmacotherapy. 2014;34(2):e14-e17. https://doi.org/10.1002/phar.1372
  18. Ritchie WB, Harrison JG, Harrison RL. Avian Medicine: Principles and Applications. Florida: Wingers; 1994. 
  19. Sinclair KM, Church ME, Farver TB, Lowenstine LJ, Owens SD, Paul-Murphy J. Effects of meloxicam on hematologic and plasma biochemical analysis variables and results of histologic examination of tissue specimens of Japanese quail (Coturnix japonica). Am J Vet Res. 2012;73(11):1720-1727. https://doi.org/10.2460/ajvr.73.11.1720
  20. Bell DJ, Freeman BM. Physiology and Biochemistry of the Domestic Fowl. New York: Academic Press; 1971. 
  21. Lierz M. Avian renal disease: pathogenesis, diagnosis, and therapy. Vet Clin North Am Exot Anim Pract. 2003;6(1):29-55. https://doi.org/10.1016/S1094-9194(02)00029-4