DOI QR코드

DOI QR Code

A Case of Mucosa-Associated Lymphoid Tissue Lymphoma (MALT Lymphoma) in Hypopharynx: A Case Report

하인두에 발생한 점막 연관성 림프조직 림프종 1예: 증례 보고

  • Min-Ju Kang (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea) ;
  • Youn-Sun Park (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea) ;
  • Ju-Eun Lee (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea) ;
  • Hyun-Bum Kim (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea)
  • 강민주 (가톨릭대학교 이비인후과교실) ;
  • 박윤선 (가톨릭대학교 이비인후과교실) ;
  • 이주은 (가톨릭대학교 이비인후과교실) ;
  • 김현범 (가톨릭대학교 이비인후과교실)
  • Received : 2022.10.17
  • Accepted : 2022.12.28
  • Published : 2023.05.30

Abstract

Malignant lymphoma rarely occurs in the larynx and hypopharynx. Few cases of malignant lymphoma in the larynx were reported in Korea. However, malignant lymphoma in the hypopharynx had been not reported in Korea. A 68-year-old woman came to the outpatient clinic with a foreign body sensation in her throat. A round, smooth margin, bright pink-colored mass was confirmed by the laryngoscopy. The patient took neck computer tomography. A small bulging of mucosa was observed, but there was no peripheral infiltration or abnormally enlarged lymph nodes. We did excision using CO2 LASER. She was finally diagnosed with mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). After diagnosis, several image studies confirmed that there was no metastatic lesion. She got only radiotherapy after that and kept a complete response state for over 2 years.

Keywords

References

  1. Takano S, Matsushita N, Oishi M, Okamoto S, Teranishi Y, Yokota C, et al. Site-specific analysis of B-cell non-Hodgkin's lymphomas of the head and neck: A retrospective 10-year observation. Acta Otolaryngol. 2015;135:1168-1171. https://doi.org/10.3109/00016489.2015.1061700
  2. Singh R, Shaik S, Negi BS, Rajguru JP, Patil PB, Parihar AS, et al. Non-Hodgkin's lymphoma: A review. J Family Med Prim Care. 2020;9:1834-1840. https://doi.org/10.4103/jfmpc.jfmpc_1037_19
  3. Storck K, Brandstetter M, Keller U, Knopf A. Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 2019;15:1-8. https://doi.org/10.1186/s13005-018-0186-0
  4. Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9:340-350. https://doi.org/10.1016/j.anndiagpath.2005.09.020
  5. Han MW, Choi SH, Kim SY, Nam SY. Primary Non-Hodgkin's Lymphoma of the Larynx. Korean J Otorhinolaryngol-Head Neck Surg. 2009;52:762-766. https://doi.org/10.3342/kjorl-hns.2009.52.9.762
  6. Firat Y, Kizilay A, Sogutlu G, Mizrak B. Primary mucosa-associated lymphoid tissue lymphoma of hypopharynx. J Craniofac Surg. 2007;18:1189-1193. https://doi.org/10.1097/scs.0b013e31815783ab
  7. Bruzgielewicz A, Rojek D, Osuch-Wocikiewicz E, Niemczyk K. [Primary location of non-Hodgin's lymphoma (type MALT) in hypopharynx--case report]. Otolaryngol Pol. 2004;58:1005-1007.
  8. Tsang RW, Gospodarowicz MK, Pintilie M, Wells W, Hodgson DC, Sun A, et al. Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome. J Clin Oncol. 2003;21:4157-4164. https://doi.org/10.1200/JCO.2003.06.085
  9. Suh C, Huh J, Roh JL. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the extracranial head and neck region: a high rate of dissemination and disease recurrence. Oral Oncol. 2008;44:949-955. https://doi.org/10.1016/j.oraloncology.2007.11.011
  10. Raderer M, Kiesewetter B, Ferreri AJ. Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). CA Cancer J Clin. 2016;66:153-171. https://doi.org/10.3322/caac.21330
  11. Zullo A, Hassan C, Ridola L, Repici A, Manta R, Andriani A. Gastric MALT lymphoma: old and new insights. Ann Gastroenterol. 2014;27:27-33.
  12. Zucca E, Arcaini L, Buske C, Johnson PW, Ponzoni M, Raderer M, et al. Marginal zone lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31:17-29. https://doi.org/10.1016/j.annonc.2019.10.010
  13. Tanimoto K, Kaneko A, Suzuki S, Sekiguchi N, Maruyama D, Kim SW, et al. Long-term follow-up results of no initial therapy for ocular adnexal MALT lymphoma. Ann Oncol. 2006;17:135-140. https://doi.org/10.1093/annonc/mdj025
  14. Ejima Y, Sasaki R, Okamoto Y, Maruta T, Azumi A, Hayashi Y, et al. Ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. Radiother Oncol. 2006;78:6-9. https://doi.org/10.1016/j.radonc.2005.11.005
  15. Zucca E, Conconi A, Laszlo D, Lopez-Guillermo A, Bouabdallah R, Coiffier B, et al. Addition of rituximab to chlorambucil produces superior event-free survival in the treatment of patients with extranodal marginal-zone B-cell lymphoma: 5-year analysis of the IELSG-19 Randomized Study. J Clin Oncol. 2013;31:565-572. https://doi.org/10.1200/JCO.2011.40.6272