The Korean Journal of Nuclear Medicine Technology (핵의학기술)

The Korean Society of Nuclear Medicine Technology (대한핵의학기술학회)
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Splenic Absorption of Radiopharmaceutical in Systemic Bone Scans Performed after Liver Transplantation

  • Sang-Hyeong Kil (Deparment of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Kyung-Nam Jo (Deparment of Nuclear Medicine, Pusan National University Yangsan Hospital) ;
  • Yung-Hyun Lim (Deparment of Nuclear Medicine, Pusan National University Yangsan Hospital)
  • Published : 2023.05.20
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Abstract

Technetium-labeled phosphate bone scan was shown to detect bone fractures and bone metastasis in early stage than general radiographs. Therefore, bone scan has become one of the most frequently performed nuclear medicine imaging examination. However, non-osseous radiopharmaceutical uptake on the bone scan are unusual findings. We report a case of diffuse splenic absorption of Tc-99m dicarboxypropane diphosphonate in patients who undergo liver transplantation.

Keywords

References

  1. Bartel TB, Kuruva M, Gnanasegaran G, Beheshti M, Cohen E J, Weissman A F, et al. SNMMI procedure standard for bone scintigraphy 4.0. J Med Radiat Sci. 2018;46(4):398-404.
  2. Sanders TG, Parsons III TW. Radiographic imaging of musculoskeletal neoplasia. Cancer Control 8.3. 2001;8(3):221-31.
  3. Kalimuthu LM, Nazar AH, Pradhan PK. Idiopathic hepatic and splenic uptake of 99mTc-methylene diphosphonate. Indian J Nucl Med. 2020;35(3):238-40. https://doi.org/10.4103/ijnm.IJNM_27_20
  4. Zuckier LS, Leonard MF. Nonosseous, nonurologic uptake on bone scintigraphy: atlas and analysis. Semin Nucl Med. 2010;40(4):242-56. https://doi.org/10.1053/j.semnuclmed.2010.02.003
  5. Pierre DM, Annegret L, Julien M, Luc-Matthieu F, Izzie Jacques N. Spleen Uptake on Bone Scan After Frequent Platelet and RBC Transfusions. Clin Nucl Med. 2016;41(10):802-3. https://doi.org/10.1097/RLU.0000000000001317
  6. Shukla LW, Lin DS, Kutka N. Splenic uptake in bone imaging. Semin Nucl Med. 1988;18(1):71-3. https://doi.org/10.1016/S0001-2998(88)80022-9
  7. Koizumi M, Suzuki T, Takahashi S, Ogata E. Transient splenic accumulation of Tc-99m HMDP caused by megaloblastic anemia. Clin Nucl Med. 2000;25(12):1024-7. https://doi.org/10.1097/00003072-200012000-00015
  8. Verma S, Kumar N, Kheruka SC, Gambhir S. Extraosseous 99mTc-methylene diphosphonate uptake on bone scan: Unusual scenario. Indian J Nucl Med. 2016;31(4):280-2. https://doi.org/10.4103/0972-3919.190799
  9. Joanie M. Idiopathic hepatic uptake of 99mTc methylene diphosphonate: A case report. J Nucl Med Technol. 2001;29(1):32-6.
  10. Hung JC, Ponto JA, Hammes RJ. Radiopharmaceutical-related pitfalls and artifacts. Semin Nucl Med. 1996;26(4):208-55. https://doi.org/10.1016/S0001-2998(96)80002-X
  11. Zhang W, Chen B, Deng H, Yang T, Ou X. Hepatic and splenic uptake on bone scintigraphy in patients with intravenous administration of 99mTc methylene diphosphonate prior to gadolinium-containing contrast. Clin Nucl Med. 2013;38(3):219-20. https://doi.org/10.1097/RLU.0b013e3182814c95
  12. Shih WJ, Coupal J. Diffuse and intense Tc-99m HMDP localization in the liver due to hypoxia secondary to respiratory failure. Clin Nucl Med. 1994;19(2):116-20. https://doi.org/10.1097/00003072-199402000-00008