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유방의 양성 선근상피세포종: 영상 특징

Benign Adenomyoepithelioma of the Breast: Imaging Characteristics

  • 신소라 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 고은영 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 한부경 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 고은숙 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 최지수 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 김혜정 (성균관대학교 의과대학 삼성서울병원 영상의학과)
  • So Ra Shin (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Eun Young Ko (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Boo-Kyung Han (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Eun Sook Ko (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ji Soo Choi (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Haejung Kim (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2022.03.02
  • 심사 : 2022.08.04
  • 발행 : 2023.03.01

초록

목적 유방의 양성 선근상피종의 영상 소견에 대해 기술하고자 한다. 대상과 방법 최근 20년 동안, 본원에서 조직 확진된 120명의 환자의 유방에서의 선근상피종을 대상으로 하였다. 43명의 환자는 유방암으로 유방 전 절제술을 시행하면서 우연히 발견되어 제외하였으며, 28명의 환자는 절제생검을 하지 않고 경피적 생검만 시행하여 제외하였고, 8명의 환자는 생검에서 양성 선근상피종으로 확인되었으나 완전 절제술 후 다른 질환으로 확진되어 제외하였다. 결과적으로, 완전 절제술 후 조직 확진된 41명 환자의 양성 선근상피종에 대해 후향적으로 임상 정보와 영상 소견을 분석하였다. 결과 유방촬영술에서 병변은 원형 또는 타원형의 모양(56%), 경계가 좋지 않음(62%), 고밀도음영(53%), 종괴형(89%)을 보였으며, 미세석회회가 없었다(95%). 유방초음파에서 병변은 의심스러운 종괴(98%), 경계가 좋지 않음(66%), 저에코(43%), 그리고 종양내 혈관성(63%)을 보였다. 유방자기공명영상에서 의심스러운 종괴(100%), 불분명한 경계(61%) 그리고 조영증강 시 지연기 소실(84%)을 보였다. 양성 선근상피종의 41개 병변 중 16개 병변은 처음 중심바늘생검에서 다른 질환으로 오진되었으며 2명의 환자는 유방암으로 오진되었다. 결론 유방의 양성 선근상피종은 유방촬영술, 유방초음파, 유방자기공명영상에서 악성 종양과 유사한 의심스러운 특징을 보인다. 양성 선근상피종을 다른 질환과 감별하는 것은 중심바늘생검만으로는 어려우며, 올바른 진단을 위해서는 완전절제술이 필요하다.

Purpose This study aimed to evaluate the radiological and clinical characteristics of benign adenomyoepitheliomas of the breast. Materials and Methods Over the last 20 years, 120 patients were histologically diagnosed with breast adenomyoepithelioma (AME) at our institution. We excluded 43 patients who were incidentally diagnosed during mastectomy for breast cancer, 28 who underwent percutaneous biopsy without further excision, and 8 who had biopsy-confirmed benign AME and were found to have another pathology after complete excision. We retrospectively reviewed the clinical records and radiological findings of the remaining 41 patients with histologically diagnosed benign breast AMEs after complete excision. Results All 41 patients underwent US; 38 underwent mammography (MG) and US; and 18 underwent MG, US, and MRI. MG detected 38 cases with a round or oval shape (56%), and mass (89%), were non-circumscribed (62%), hyperdense (53%), and without microcalcifications (95%). Breast US revealed suspicious masses (98%) with a non-circumscribed margin (66%), hypoechogenicity (43%), and intratumoral vascularity (63%). All lesions on breast MRI showed suspicious masses (100%) with ill-defined margins (61%), and 84% showed wash-out kinetics. Benign AMEs showed suspicious features of Breast Imaging Reporting and Data System (BI-RADS) category 4 or 5 in 83%-95% of the MG, US, and MRI. Sixteen of the 41 cases were misdiagnosed on the initial core needle biopsy and two were diagnosed as malignancy. Conclusion Benign breast AME often shows suspicious radiological features mimicking a malignant mass on MG, US, and MRI. Differentiating benign AME from other pathologies might be difficult on core needle biopsy, and complete excision is needed for a correct diagnosis.

키워드

참고문헌

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