한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제27권1호
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  • Pages.25-37
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  • 2023
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Effects of Acetaminophen on Reproductive Activities in Male Golden Hamsters

  • Chae Yeon Lee (Department of Life Science, College of Health Science and Welfare, Yong-In University) ;
  • Hyunji Hwang (Department of Life Science, College of Health Science and Welfare, Yong-In University) ;
  • Jin-Soo Park (Department of Biotechnology, Sangmyung University) ;
  • Sung-Ho Lee (Department of Biotechnology, Sangmyung University) ;
  • Chang Eun Park (Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul University) ;
  • Yong-Pil Cheon (Division of Developmental Biology and Physiology, Department of Biotechnology, Sungshin University) ;
  • Donchan Choi (Department of Life Science, College of Health Science and Welfare, Yong-In University)
  • 투고 : 2022.12.29
  • 심사 : 2023.03.01
  • 발행 : 2023.03.15
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초록

Acetaminophen [Paracetamol, N-acetyl-para-aminophenol (APAP)] is a common over-the-counter analgesic agent as nonsteroidal anti-inflammatory drugs (NSAIDs). The high doses or the long-term treatment of acetaminophen via usual gavage feeding resulted in damage of testicles that presented recoverable impairment, as well as liver and kidney. The influence of acetaminophen was examined in male golden hamsters treated with acetaminophen-containing diet feeding. They were divided into 5 groups and subjected to this experiment for 4 weeks: animals housed in long photoperiod (LP) as LP control, animals housed in short photoperiod (SP) for 4 weeks as SP control (SP4), and groups of animals treated with low, middle, and high concentrations of acetaminophen (Low, Middle, High groups). Also animals housed in SP for 8 weeks were included (SP8) to contrast testicular activities, if necessary. As results, spermatozoa filled the seminiferous tubules of the testicles of animals in LP control and SP4 groups. The aspects were seen in the animals taken diets of low and middle doses of acetaminophen. The animals who fed high dose of acetaminophen showed large or small testicles. The large testicles displayed all germ cells at the steps of spermatogenesis. The small testicles presented no sperm as the animals housed in SP for 8 weeks. Thus these results indicate that acetaminophen invokes the antigonadal effects and accelerates the regressing process of the testicles in the animals compared to the animals exposed to SP.

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