Acknowledgement
The authors wish to thank Shanghai Taiwei Pharmaceutical Company Limited (China) and ZHT Sci-Tech (Beijing) Co, Ltd (China)for providing the soy lecithin (SL) and soy isoflavone (SIF).
References
- Wu HZ, Ong KL, Seeher K, Armstrong NJ, Thalamuthu A, Brodaty H, Sachdev P, Mather K. Circulating microRNAs as biomarkers of Alzheimer's disease: a systematic review. J Alzheimers Dis 2016;49:755-66.
- Rius-Perez S, Tormos AM, Perez S, Talens-Visconti R. Vascular pathology: cause or effect in Alzheimer disease? Neurologia (Engl Ed) 2018;33:112-20. https://doi.org/10.1016/j.nrleng.2015.07.008
- Roher AE, Debbins JP, Malek-Ahmadi M, Chen K, Pipe JG, Maze S, Belden C, Maarouf CL, Thiyyagura P, Mo H, et al. Cerebral blood flow in Alzheimer's disease. Vasc Health Risk Manag 2012;8:599-611. https://doi.org/10.2147/VHRM.S34874
- Xi YD, Yu HL, Ding J, Ma WW, Yuan LH, Feng JF, Xiao YX, Xiao R. Flavonoids protect cerebrovascular endothelial cells through Nrf2 and PI3K from β-amyloid peptide-induced oxidative damage. Curr Neurovasc Res 2012;9:32-41.
- Soybean IS. Soybean and processed soy foods ingredients, and their role in cardiometabolic risk prevention. Recent Pat Food Nutr Agric 2015;7:75-82. https://doi.org/10.2174/2212798407666150629123839
- Mourad AM, de Carvalho Pincinato E, Mazzola PG, Sabha M, Moriel P. Influence of soy lecithin administration on hypercholesterolemia. Cholesterol 2010;2010:824813.
- Ramdath DD, Padhi EM, Sarfaraz S, Renwick S, Duncan AM. Beyond the cholesterol-lowering effect of soy protein: a review of the effects of dietary soy and its constituents on risk factors for cardiovascular disease. Nutrients 2017;9:324.
- Xi YD, Yu HL, Ma WW, Ding BJ, Ding J, Yuan LH, Feng JF, Xiao R. Genistein inhibits mitochondrial-targeted oxidative damage induced by β-amyloid peptide 25-35 in PC12 cells. J Bioenerg Biomembr 2011;43:399-407. https://doi.org/10.1007/s10863-011-9362-7
- Ding BJ, Ma WW, He LL, Zhou X, Yuan LH, Yu HL, Feng JF, Xiao R. Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-κB activity in rats. Int J Dev Neurosci 2011;29:537-42. https://doi.org/10.1016/j.ijdevneu.2011.04.002
- Xi YD, Li XY, Yu HL, Jing H, Ma WW, Yuan LH, Zhang DD, Wu J, Xiao R. Soy isoflavone antagonizes the oxidative cerebrovascular injury induced by β-amyloid peptides 1-42 in rats. Neurochem Res 2014;39:1374-81. https://doi.org/10.1007/s11064-014-1319-x
- Baumgartner S, Bruckert E, Gallo A, Plat J. The position of functional foods and supplements with a serum LDL-C lowering effect in the spectrum ranging from universal to care-related CVD risk management. Atherosclerosis 2020;311:116-23. https://doi.org/10.1016/j.atherosclerosis.2020.07.019
- Evans M, Njike VY, Hoxley M, Pearson M, Katz DL. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause 2007;14:141-9. https://doi.org/10.1097/01.gme.0000227404.83686.1b
- Xi YD, Li XY, Ding J, Yu HL, Ma WW, Yuan LH, Wu J, Xiao R. Soy isoflavone alleviates Aβ1-42-induced impairment of learning and memory ability through the regulation of RAGE/LRP-1 in neuronal and vascular tissue. Curr Neurovasc Res 2013;10:144-56. https://doi.org/10.2174/1567202611310020007
- Dunn AK. Laser speckle contrast imaging of cerebral blood flow. Ann Biomed Eng 2012;40:367-77. https://doi.org/10.1007/s10439-011-0469-0
- Miners JS, Palmer JC, Love S. Pathophysiology of hypoperfusion of the precuneus in early Alzheimer's disease. Brain Pathol 2016;26:533-41. https://doi.org/10.1111/bpa.12331
- Goulay R, Mena Romo L, Hol EM, Dijkhuizen RM. From stroke to dementia: a comprehensive review exposing tight interactions between stroke and amyloid-β formation. Transl Stroke Res 2020;11:601-14. https://doi.org/10.1007/s12975-019-00755-2
- Di Marco LY, Venneri A, Farkas E, Evans PC, Marzo A, Frangi AF. Vascular dysfunction in the pathogenesis of Alzheimer's disease--a review of endothelium-mediated mechanisms and ensuing vicious circles. Neurobiol Dis 2015;82:593-606. https://doi.org/10.1016/j.nbd.2015.08.014
- Xu J, Hu H, Chen B, Yue R, Zhou Z, Liu Y, Zhang S, Xu L, Wang H, Yu Z. Lycopene protects against hypoxia/reoxygenation injury by alleviating ER stress induced apoptosis in neonatal mouse cardiomyocytes. PLoS One 2015;10:e0136443.
- Ma W, Ding B, Yu H, Yuan L, Xi Y, Xiao R. Genistein alleviates β-amyloid-induced inflammatory damage through regulating Toll-like receptor 4/nuclear factor κB. J Med Food 2015;18:273-9. https://doi.org/10.1089/jmf.2014.3150
- Ding J, Yu HL, Ma WW, Xi YD, Zhao X, Yuan LH, Feng JF, Xiao R. Soy isoflavone attenuates brain mitochondrial oxidative stress induced by β-amyloid peptides 1-42 injection in lateral cerebral ventricle. J Neurosci Res 2013;91:562-7. https://doi.org/10.1002/jnr.23163
- Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR. Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging (Albany NY) 2012;4:590-605. https://doi.org/10.18632/aging.100486
- Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr 2010;47:246-55. https://doi.org/10.3164/jcbn.10-62
- Punithavathi VR, Prince PS. Combined effects of quercetin and alpha-tocopherol on lipids and glycoprotein components in isoproterenol induced myocardial infarcted Wistar rats. Chem Biol Interact 2009;181:322-7. https://doi.org/10.1016/j.cbi.2009.07.002
- Korte N, Nortley R, Attwell D. Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease. Acta Neuropathol 2020;140:793-810. https://doi.org/10.1007/s00401-020-02215-w
- Guo Y, Li X, Zhang M, Chen N, Wu S, Lei J, Wang Z, Wang R, Wang J, Liu H. Age- and brain region-associated alterations of cerebral blood flow in early Alzheimer's disease assessed in AβPPSWE/PS1ΔE9 transgenic mice using arterial spin labeling. Mol Med Rep 2019;19:3045-52. https://doi.org/10.3892/mmr.2019.9950
- Qiu L, Ng G, Tan EK, Liao P, Kandiah N, Zeng L. Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice. Sci Rep 2016;6:23964.
- Austin BP, Nair VA, Meier TB, Xu G, Rowley HA, Carlsson CM, Johnson SC, Prabhakaran V. Effects of hypoperfusion in Alzheimer's disease. J Alzheimers Dis 2011;26 Suppl 3:123-33. https://doi.org/10.3233/JAD-2011-0010
- Aabdallah DM, Eid NI. Possible neuroprotective effects of lecithin and alpha-tocopherol alone or in combination against ischemia/reperfusion insult in rat brain. J Biochem Mol Toxicol 2004;18:273-8. https://doi.org/10.1002/jbt.20037
- Zhao H, Liang J, Li X, Yu H, Li X, Xiao R. Folic acid and soybean isoflavone combined supplementation protects the post-neural tube closure defects of rodents induced by cyclophosphamide in vivo and in vitro. Neurotoxicology 2010;31:180-7. https://doi.org/10.1016/j.neuro.2009.12.011
- Sadhukhan P, Saha S, Dutta S, Mahalanobish S, Sil PC. Nutraceuticals: an emerging therapeutic approach against the pathogenesis of Alzheimer's disease. Pharmacol Res 2018;129:100-14. https://doi.org/10.1016/j.phrs.2017.11.028
- Das SK, Gupta G, Rao DN, Vasudevan DM. Effect of lecithin with vitamin-B complex and tocopheryl acetate on long-term effect of ethanol induced immunomodulatory activities. Indian J Exp Biol 2007;45:683-8.
- Kim SB, Assefa F, Lee SJ, Park EK, Kim SS. Combined effects of soy isoflavone and lecithin on bone loss in ovariectomized mice. Nutr Res Pract 2021;15:541-54. https://doi.org/10.4162/nrp.2021.15.5.541